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Actions of Insulin and Igf-I on Vascular Smooth Muscle Cation and Glucose Metabolism

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Pharmacological Control of Calcium and Potassium Homeostasis

Part of the book series: Medical Science Symposia Series ((MSSS,volume 9))

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Abstract

Recent data indicates that impaired insulin action predisposes to increased vascular smooth muscle [1-26] (VSM) tone, the hallmark of hypertension associated with diabetes mellitus. This research has established VSM as an “insulin sensitive tissue” like skeletal muscle tissue and adipocytes. Insulin and insulin-like growth factor (IGF-I) regulate VSM intracellular cation metabolism through attenuating effects on inward calcium (Ca2+) currents [1 10 15 27 28] and by direct effects on VSMNa+,K+-ATPase pump expression and activity[29 30] and that IGF-I and insulin stimulate glucose uptake in VSM cells (VSMC). IGF-1 and insulin are structurally related [17] share receptors [17 18] and have similar post-receptor actions [17 18] (Figure 1). Unlike insulin, which must transverse the endothelium before acting on VSMC in vivo, IGF-1 is synthesized by VSMC [19]. Thus, IGF-1 may have more relevance than insulin in VSMC physiology.

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Authors and Affiliations

  1. Wayne State University School of Medicine, Detroit, 48201, Michigan, USA

    James R Sowers

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  1. James R Sowers
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Editors and Affiliations

  1. Laboratory of Pharmacology, Catholic University of Louvain, Brussels, Belgium

    T. Godfraind

  2. Center of Physiology, Hypertension Clinic, University of Milan, Milan, Italy

    G. Mancia

  3. Institute of Pharmacological Sciences, University of Milan, Milan, Italy

    M. P. Abbracchio

  4. Baylor College of Medicine, Houston, Texas, USA

    L. Aguilar-Bryan

  5. Institute of Pharmacology, University of Pavia, Pavia, Italy

    S. Govoni

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© 1995 Springer Science+Business Media Dordrecht

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Sowers, J.R. (1995). Actions of Insulin and Igf-I on Vascular Smooth Muscle Cation and Glucose Metabolism. In: Godfraind, T., Mancia, G., Abbracchio, M.P., Aguilar-Bryan, L., Govoni, S. (eds) Pharmacological Control of Calcium and Potassium Homeostasis. Medical Science Symposia Series, vol 9. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-0117-2_14

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  • DOI: https://doi.org/10.1007/978-94-011-0117-2_14

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-4056-3

  • Online ISBN: 978-94-011-0117-2

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