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Experimental and Clinical Cardiac Beta-receptor Studies

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Cardiac Positron Emission Tomography

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 166))

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Abstract

In the last decades increasing information has become available on changes in cardiac receptors during pathophysiological circumstances. With the advent of positron emission tomography (PET) imaging it is now theoretically possible to measure receptor density noninvasively in vivo. In the field of sympathetic innervation and postsynaptic cardiac ß-adrenoceptors in the heart, the first data using the PET technique have been published. Beta-adrenoceptors have been quantified by in vitro binding assays and changes in ß-adrenoceptor density have been associated with congestive heart failure,1, 2 myocardial ischemia,3, 4 cardiomyopathy,5, 6 valvular diseases,7 hypertension,8 diabetes,9, 10 hyperthyroidism11 and chronic drug administration.12, 13 Cardiac ß1adrenoceptors exert positive inotropic, lusitropic, and chronotropic effects, whereas cardiac ß2-adrenoceptors mainly have positive chronotropic and vasodilatory effects. Alteration in number of these receptors will affect cardiac function, especially since the human heart has a small receptor reserve for ß-agonists.2

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Authors
  1. Rutger L. Anthonio
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  2. Aren van Waarde
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  3. Antoon T. M. Willemsen
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  4. Jan Pruim
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  5. Wiek H. van Gilst
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  6. Paul K. Blanksma
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  7. Willem Vaalburg
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  8. Kong I. Lie
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Editor information

Editors and Affiliations

  1. Department of Cardiology, University Hospital Leiden, Leiden, The Netherlands

    E. E. van der Wall

  2. Department of Cardiology, University Hospital Groningen, Groningen, The Netherlands

    P. K. Blanksma

  3. Department of Cardiology, Martini Hospital, Groningen, The Netherlands

    M. G. Niemeyer

  4. PET Centre, University Hospital Groningen, Groningen, The Netherlands

    A. M. J. Paans

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© 1995 Springer Science+Business Media Dordrecht

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Anthonio, R.L. et al. (1995). Experimental and Clinical Cardiac Beta-receptor Studies. In: van der Wall, E.E., Blanksma, P.K., Niemeyer, M.G., Paans, A.M.J. (eds) Cardiac Positron Emission Tomography. Developments in Cardiovascular Medicine, vol 166. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-0023-6_17

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  • DOI: https://doi.org/10.1007/978-94-011-0023-6_17

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-4014-3

  • Online ISBN: 978-94-011-0023-6

  • eBook Packages: Springer Book Archive

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