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Ulcer and Non-Ulcer Dyspepsias pp 61–115Cite as

Peptic Ulcer

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Part of the book series: Practical Clinical Medicine ((PCLM))

Abstract

The epidemiological profiles of gastric and duodenal ulcer have changed considerably during the twentieth century and herein may lie valuable clues to their aetiologies.

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References

  1. Crean, G. P. (1984). Symptomatic diagnosis of dyspepsia. In Lancaster Smith, M. J. (ed.) Peptic Ulcer, pp. 14–20. ( London: Update Publications )

    Google Scholar 

  2. De Dombal, F. T. (1981). Analysis of foregut symptoms. In Baron, J. H. and Moody, F. G. (eds.) International Medical Review: Gastroenterology I, Foregut, pp. 49–66. ( London: Butterworth )

    Google Scholar 

  3. Lennard Jones, J. E. (1983). Functional gastrointestinal disorders. N. Engl. J. Med., 308, 431–435

    Article  Google Scholar 

  4. Doll, R., Jones, F. A. and Bukatzsch, M. M. (1950). MRC Special Report Series no. 276, London

    Google Scholar 

  5. Watkinson, G. (1960). The incidence of chronic peptic ulcer found at necropsy. Gut 1, 14–31

    Article  PubMed  CAS  Google Scholar 

  6. Ihamaki, T., Varis, K. and Siurala, M. (1979). Morphological, functional and immunological state of gastric mucosa in gastric carcinoma families. Comparison with a computer matched family sample. Scand. J. Gastroenterol., 14, 801–812

    Article  PubMed  CAS  Google Scholar 

  7. Pulvertaft, C. N. (1968). Comments on the incidence and natural history of gastric and duodenal ulcer. Postgrad. Med. J., 44, 597–602

    Article  PubMed  CAS  Google Scholar 

  8. Bonnevie, O. (1975). The incidence of gastric ulcer in Copenhagen County. Gastroenterology, 10, 231–239

    CAS  Google Scholar 

  9. Bonnevie, O. (1975). The incidence of duodenal ulcer in Copenhagen County. Gastroenterology, 10, 385–393

    CAS  Google Scholar 

  10. Kurata, J. H., Honda, G. D. and Frankl, H. (1983). The incidence of gastric and duodenal ulcers in a large HMO. Presented at the 111th Annual Meeting of the American Public Health Association (abstract)

    Google Scholar 

  11. National Centre for Health Statistics. (1979). Prevalence of selected chronic digestive conditions, United States 1975. Vital and Health Statistics, Department of Health, Education and Welfare, 79–1558

    Google Scholar 

  12. Brinton, W. (1857). On the Pathology, Symptoms and Treatment of Ulcer of the Stomach. ( Edinburgh: Churchill Livingstone )

    Google Scholar 

  13. Coggon, D., Lambert, P. and Langman, M. J. S. (1981). Twenty years of hospital admissions for peptic ulcer in England and Wales. Lancet, 1, 1302–1304

    Article  PubMed  CAS  Google Scholar 

  14. Elashoff, J. D. and Grossman, M. I. (1980). Trends in hospital admissions and death rates from peptic ulcer in the United States from 19701978. Gastroenterology, 78, 280–285

    PubMed  CAS  Google Scholar 

  15. Almy, T. P. et al. (1975). Prevalence and significance of digestive disease. Gastroenterology, 68, 1351–1371

    PubMed  CAS  Google Scholar 

  16. Mendeloff, A. I. (1974). What has been happening to duodenal ulcer? Gastroenterology, 64, 1020–1022

    Google Scholar 

  17. Vogt, T. M. and Johnson, R. E. (1980). Recent changes in the incidence of duodenal and gastric ulcer. Am. J. Epidemiol., 111, 713–720

    PubMed  CAS  Google Scholar 

  18. Taylor, P. (1974). Sickness absence; Facts and misconceptions. J. R. Coll. Physicians, London, 8, 315–333

    CAS  Google Scholar 

  19. Kurata, J. H. and Haile, B. M. (1984). Epidemiology of peptic disease. Clin. Gastroenterol., 132, 289–307

    Google Scholar 

  20. Malhotra, S. L. (1965). The role of saliva in the aetiology of peptic ulcer. Br. Med. J., 1, 1220–1222

    Article  PubMed  CAS  Google Scholar 

  21. Langman, M. J. S. (1979). The Epidemiology of Chronic Digestive Disease. ( London: Edward Arnold )

    Google Scholar 

  22. Harrison, A., Elashoff, J. and Grossman, M. I. (1979). Cigarette smoking and ulcer disease. In The Surgeon General’s Report on Smoking and Health, pp. 9–21. ( US Department of Health, Education and Welfare, Public Health Service )

    Google Scholar 

  23. Paffenbarger, R. S., Wing, A. L. and Hyde, R. T. (1974). Chronic disease in former college students. Am. J. Epidemiol., 100, 307–315

    PubMed  Google Scholar 

  24. Petitti, D. B., Friedman, G. D. and Kahn, W. (1982). Peptic ulcer disease and the tar and nicotine yield of currently smoked cigarettes. J. Chronic Dis., 35, 503–507

    Article  PubMed  CAS  Google Scholar 

  25. Hammond, E. C. (1966). Smoking in relation to the death rates of one million men and women. In Haenszel, W. (ed.) Epidemiological Approaches to the Study of Cancer and Other Chronic Diseases. National Cancer Institute Monograph 19, pp. 127–204. ( Bethesda: US Public Health Service )

    Google Scholar 

  26. Friedman, G. D., Siegelaub, A. B. and Seltzer, C. C. (1974). Cigarettes, alcohol, coffee and peptic ulcer. N. Engl. J. Med., 290, 469–473

    Article  PubMed  CAS  Google Scholar 

  27. Doll, R., Jones, F. and Pygott, F. (1958). Effect of smoking on the production and maintenance of gastric and duodenal ulcers. Lancet, 1, 657–662

    Article  PubMed  CAS  Google Scholar 

  28. Gugler, R., Rohner, H. G., Kratochvil, P. et al. (1982). Effect of smoking on duodenal ulcer healing with cimetidine and oxmetidine. Gut, 23, 866–871

    Article  PubMed  CAS  Google Scholar 

  29. Peterson, W. L., Sturdevant, R. A. L., Frankl, H. D. et al. (1977). Healing of duodenal ulcer with an antacid regimen. N. Engl. J. Med., 297, 341–345

    Article  PubMed  CAS  Google Scholar 

  30. Korman, M. G., Hansky, J., Eaves, E. R. and Schmidt, G. T. (1983). Influence of cigarette smoking on healing and relapse in duodenal ulcer disease. Gastroenterology, 85, 871–874

    PubMed  CAS  Google Scholar 

  31. Read, N. W. and Grech, P. (1973). Effect of cigarette smoking on competence of the pylorus: preliminary study. Br. Med. J., 3, 313316

    Google Scholar 

  32. Valenzuela, J., Defelippi, C. and Csendes, A. (1976). Manometric studies on the human pyloric sphincter. Gastroenterology, 70, 481–483

    PubMed  CAS  Google Scholar 

  33. Murthy, S., Dinoso, V., Clearfield, H. and Chey, W. (1977). Simultaneous measurement of basal pancreatic, gastric acid secretion, plasma gastrin.and secretion during smoking. Gastroenterology, 73, 758–761

    PubMed  CAS  Google Scholar 

  34. McCready, D. R., Clark, L. and Cohen, M. M. (1985). Cigarette smoking reduces human gastric luminal prostaglandin E2. Gut, 26, 1192 1196

    Google Scholar 

  35. Piper, D. W., McIntosh, J. H., Greig, M. and Shy, C. M. (1982). Environmental factors and chronic gastric ulcer: a case control study of the association of smoking, alcohol and heavy analgesic ingestion with the exacerbation of chronic gastric ulcer. Scand. J. Gastroenterol., 17, 721–729

    Article  PubMed  CAS  Google Scholar 

  36. Langman, M. J. S. and Cooke, A. R. (1976). Gastric and duodenal ulcer and their associated diseases. Lancet, 1, 680–683

    Article  PubMed  CAS  Google Scholar 

  37. Cohen, S. and Booth, G. H. Jr. (1975). Gastric acid secretion and lower oesophageal sphincter pressure in response to coffee and caffeine. N. Engl. J. Med., 293, 897–899

    Article  PubMed  CAS  Google Scholar 

  38. Jorgensen, T. G. and Gyntelberg, F. (1976). Occurrence of peptic ulcer disease in Copenhagen males age 40–59. Danish Medical Bulletin, 23, 23–28

    PubMed  CAS  Google Scholar 

  39. Truelove, S. C. (1960). Stilboestrol, phenobarbitone and diet in chronic duodenal ulcer. Br. Med. J., 2, 559

    Article  PubMed  CAS  Google Scholar 

  40. Doll, R. (1964). Medical treatment of gastric ulcer. Scott. Med. J., 9 (5), 183–196

    PubMed  CAS  Google Scholar 

  41. Buchman, E., Kaung, D. T., Dolan, K. and Knapp, R. N. (1969). Unrestricted diet in the treatment of duodenal ulcer. Gastroenterology, 56 (6), 1016–1026

    PubMed  CAS  Google Scholar 

  42. Malhotra, S. L. (1978). A comparison of unrefined meat and rice diets in the management of duodenal ulcer. Postgrad. Med. J., 54, 6–9

    Article  PubMed  CAS  Google Scholar 

  43. Rydning, A., Berstad, A., Aadland, E. and Odegaard, B. (1982). Prophylactic effect of dietary fibre in duodenal ulcer disease. Lancet, 2, 736–739

    Article  PubMed  CAS  Google Scholar 

  44. Billington, B. P. (1963). The Australian gastric ulcer change: interstate variations. Aust. Ann. Med., 12, 153–159

    PubMed  CAS  Google Scholar 

  45. Levy, M. (1974). Aspirin use in patients with major upper gastrointestinal bleeding and peptic ulcer disease. N. Engl. J. Med., 290, 1158–1162

    Article  PubMed  CAS  Google Scholar 

  46. Davenport, ‘H. W. (1967). Salicylate damage to the gastric mucosal barrier. N. Engl. J. Med., 276, 1307

    CAS  Google Scholar 

  47. Vane, J. R. (1976). Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature, 231, 232–235

    Google Scholar 

  48. Conn, H. O. and Blitzer, B. I. (1976). Medical progress: non-association of adrenocorticosteroid therapy and peptic ulcer. N. Engl. J. Med., 294, 473

    Article  PubMed  CAS  Google Scholar 

  49. Messer, J., Reitman, D., Sacks, H. S. et al. (1983). Association of adreno-corticoid therapy and peptic ulcer disease. N. Engl. J. Med., 309, 21–24

    Article  PubMed  CAS  Google Scholar 

  50. Sommerville, K., Faulkner, G., Langman, M. (1986). Non-steroidal anti-inflammatory drugs and bleeding peptic ulcer. Lancet, 1, 462–464

    Article  Google Scholar 

  51. Collier, D. St J. and Pain, J. A. (1985). Non-steroidal anti-inflammatory drugs and peptic ulcer perforation. Gut, 26, 359–363

    Article  PubMed  CAS  Google Scholar 

  52. Walt, R., Katschinski, B., Logan, R. et al. (1986). Rising frequency of ulcer perforation in elderly people in the United Kingdom. Lancet, 1, 489–492

    Article  PubMed  CAS  Google Scholar 

  53. Wolf, S. and Wolff, H. G. (1943). Human Gastric Function, 1st Edn. ( New York: Oxford University Press )

    Google Scholar 

  54. Peters, M. N. and Richardson, C. T. (1983). Stressful life events, acid hypersecretion and ulcer disease. Gastroenterology, 84, 114–119

    PubMed  CAS  Google Scholar 

  55. Thomas, J., Grieg, M. and Piper, D. W. (1980). Chronic gastric ulcer and life events. Gastroenterology, 78, 905–911

    PubMed  CAS  Google Scholar 

  56. Piper, D. W., McIntosh, J. H., Ariotti, D. E. et al. (1981). Life events and chronic duodenal ulcer: a case control study. Gut, 22, 1011–1017

    Article  PubMed  CAS  Google Scholar 

  57. Feldman, E. J., Elashoff, J. D., Samloff, I. M. and Grossman, M. I. (1980). Psychologic stress and duodenal ulcer. N. Engl. J. Med., 302, 1206

    PubMed  CAS  Google Scholar 

  58. Weiner, H., Thaler, M., Reiser, M. E. and Mirsky, I. A. (. 1957 ). Etiology of duodenal ulcer: relation of specific psychological characteristics to rate of gastric secretion (serum pepsinogen). Psychosom. Med., 24, 398–416

    Google Scholar 

  59. Rotter, J. I. Peptic ulcer. In Emery, A. E. H. and Rimoin, D. L. (eds.) Principles and Practice of Medical Genetics,pp. 863–878 (Edinburgh: Churchill Livingstone)

    Google Scholar 

  60. Langman, M. J. S. (1973). Blood group and alimentary disorders. Clin. Gastroenterol., 2, 497–506

    Google Scholar 

  61. Sturdevant, R. A. L., Isenberg, J. L., Secrist, D. and Ansfield, J. (1977). Antacid and placebo produced similar pain relief in duodenal ulcer patients. Gastroenterology, 72, 1–5

    PubMed  CAS  Google Scholar 

  62. Lorber, S. H., Stelzer, F. A. and Mayer, E. M. (1978). Effect of antacid and placebo on pain of duodenal ulcer. Gastroenterology, 74, 1058

    Google Scholar 

  63. Rune, S. J. and Zachariasson, A. (1980). Acute relief of epigastric pain by antacid in duodenal ulcer patients. Scand. J. Gastroenterol. (supplement), 15, 41–45

    Google Scholar 

  64. Peterson, W. L., Sturdevant, R. A. L., Frankl, H. D. et al. (1977). Healing of duodenal ulcer with an antacid regimen. N. Engl. J. Med., 297, 341–345

    Article  PubMed  CAS  Google Scholar 

  65. Lam, S. K., Lam, K. C., Lai, C. L. et al. (1979). Treatment of duodenal ulcer with antacid and sulpiride: A double blind study. Gastroenterology, 315–322

    Google Scholar 

  66. Berstad, A., Rydning, A., Aadland, E. et al. (1982). Controlled clinical trial of duodenal ulcer healing with antacid tablets. Scand. J. Gastroenterol., 17 (7): 953–959

    Article  PubMed  CAS  Google Scholar 

  67. Cayer, D., Sohmer, M. F. and Ruffin, J. M. (1957). The effect of prolonged continuous therapy on the course of chronic recurrent peptic ulcer: antacid therapy with dihydroxy aluminium aminoacetate (alglyn). N. Carolina Med. J., 18, 315–317

    PubMed  CAS  Google Scholar 

  68. Baker, L. R. I., Ackrill, P., Catell, W. R. et al. (1974). Iatrogenic osteomalacia and myopathy due to phosphate depletion. Br. Med. J., iii, 150–152

    Google Scholar 

  69. Spencer, H. and Lender, M. (1979). Adverse effects of aluminium-containing antacids on mineral metabolism. Gastroenterology, 76, 603–606

    PubMed  CAS  Google Scholar 

  70. Fordtran, J. S. (1968). Acid rebound. N. Engl. J. Med., 279, 900–905

    Article  PubMed  CAS  Google Scholar 

  71. Barry, R. E. and Ford, J. (1978). Sodium content and neutralizing capacity of some commonly used antacids. Br. Med. J., 276, 413

    Article  Google Scholar 

  72. Ekenved, G., Magnusson, A., Bodemar, G. and Walan, A. (1977). Influence of food on the effect of propantheline and 1-hyoscyamine on salivation. Scand. J. Gastroenterol., 12, 963–966

    Article  PubMed  CAS  Google Scholar 

  73. Post, C. and Walan, A. Influence of food on the effect of 1-hyoscyamine and benzilonium-bromide in man. Scand. J. Gastroenterol. 45, (Suppl.) 77

    Google Scholar 

  74. Ivey, K. J. (1978). Anticholinergics: do they work in peptic ulcer? Gastroenterology, 68, 154–166

    Google Scholar 

  75. Feldman, M., Richardson, C. T., Peterson, W. L. et al. (1977). Effect of low dose propantheline on food stimulated acid secretion. N. Engl. J. Med., 297, 1427–1430

    Article  PubMed  CAS  Google Scholar 

  76. Hammer, R., Berrie, C. P., Birdsall, N.J. M. et al. (1980). Pirenzipine distinguishes between different subclasses of muscarinic receptors. Nature, 283, 90–92

    Article  PubMed  CAS  Google Scholar 

  77. Stenquist, B., Hagland, U., Lind, T. and Olbe, L. (1982). The effect of different anticholinergics on the gastric acid response to sham feeding in man Scand. J. Gastroenterol. 72, (Suppl.), 165–167

    CAS  Google Scholar 

  78. Texter, E. C. and Reilly, P. A. (1982). The efficacy and selectivity of pirenzipine. Review and commentary. Scand. J. Gastroenterol., 72, (Suppl.), 237–246

    Google Scholar 

  79. Adami, H. O., Bjorklund, O., Enander, L. K. et al. (1982). Cimetidine or propantheline combined with antacid therapy for short term treatment of duodenal ulcer. Dig. Dis. Sci., 27 (5), 388–393

    Article  PubMed  CAS  Google Scholar 

  80. Ström, M., Gotthard, R., Bodemar, G. and Walan, A. (1981). Antacid/anti-cholinergic, cimetidine and placebo in treatment of active peptic ulcers. Scand. J. Gastroenterol., 16, 593–602

    Article  PubMed  Google Scholar 

  81. Meeroff, M., Serchio, A. and Tagablue, N. R. (1981). Anticholinergic and antacid tablets versus cimetidine in the treatment of active duodenal ulcers. Curr. Ther. Res., 29 (6), 866–873

    Google Scholar 

  82. Walan, A. (1984). Antacids and anticholinergics in the treatment of duodenal ulcer. In Isenberg, J. I. and Johansson, C. (eds.) Peptic Ulcer Disease, Clinics in Gastroenterology, pp. 473–499 ( London: Saunders )

    Google Scholar 

  83. Dal Monte, P. R., Bianchi Porro, G., Petrulo, M. et al. (1982). Long term treatment of duodenal ulcer with pirenzipine. A double blind placebo controlled trial. Scand. J. Gastroenterol., 72, (Suppl.), 225–227

    Google Scholar 

  84. Pounder, R. E., Williams, J. G., Russell, R. C. G. et al. (1976). Inhibition of food-stimulated gastric acid secretion by cimetidine. Gut, 17, 161–168

    Article  PubMed  CAS  Google Scholar 

  85. Walt, R. P., Male, P-J, Rawlings, J. et al. (1981). Comparison of the effects of ranitidine, cimetidine and placebo on the 24 hour intra-gastric acidity and nocturnal acid secretion in patients with duodenal ulcer. Gut, 22, 49–54

    Article  PubMed  CAS  Google Scholar 

  86. Thomas, J. M. and Misiewicz, G. (1984) Histamine H2 receptor antagonists in the short and long-term treatment of duodenal ulcer. In Isenberg, J. I. and Johansson, C. (eds.) Peptic Ulcer Disease, Clinics in Gastroenterology, pp. 501–541 ( London: W. B. Saunders ).

    Google Scholar 

  87. Malchow, H., Sewing, K. F., Albinus, M. et al. (1978). In-patient treatment of peptic ulcer with cimetidine 1. Effect on the healing of duodenal ulcer. Deutsche Medizinische Wochenschrift, 103, 149–152

    Article  PubMed  CAS  Google Scholar 

  88. Villalobos, J. J., Elizondo, J., Guevara, L. and Centeno, F. (1978). Cimetidine in the treatment of duodenal ulcer: Double blind study. J. Int. Med. Res., 6, 351

    PubMed  CAS  Google Scholar 

  89. Pounder, R. E. (1981). Model of medical treatment for duodenal ulcer. Lancet, 1: 29–30

    Article  PubMed  CAS  Google Scholar 

  90. Capurso, L., Dal Monte, P. R., Mazzeo, F. et al. (1984). Comparison of cimetidine 800 mg once daily and 400 mg twice daily in acute duodenal ulceration. Br. Med. J., 289, 1418–1420

    Article  CAS  Google Scholar 

  91. Isenberg, J. I., Peterson, W. L., Elashoff, J. D. et al. (1983). Healing of benign gastric ulcer with low dose antacid or cimetidine. A double blind randomized placebo-controlled trial. N. Engl. J. Med., 308, 1319–1324

    Article  PubMed  CAS  Google Scholar 

  92. Akdamar, K., Dyke, W., Englert, E. et al. (1981). Cimetidine versus placebo in the treatment of benign gastric ulcer: a multi-centre double blind study. Gastroenterology,80, 1098 (abstract)

    Google Scholar 

  93. Ashton, M. G., Holdsworth, C. D., Ryan, F. P. and Moore, M. (1982). Healing of gastric ulcers after one, two and three months of ranitidine. Br. Med. J., 284, 467–468

    Article  CAS  Google Scholar 

  94. Wright, J. P., Marks, I. N., Mee, A. S. et al. (1982). Ranitidine in the treatment of gastric ulceration. S. Afr. J. Med., 61, 155–158

    CAS  Google Scholar 

  95. Ireland, A., Colin Jones, D. G., Gear, P. et al. (1984). Ranitidine 150 mg twice daily vs 300 mg nightly in treatment of duodenal ulcers. Lancet, 2, 274–276

    Article  PubMed  CAS  Google Scholar 

  96. Lishman, A. H. and Record, C. O. (1982) Ranitidine in the management of duodenal ulceration: controlled and open comparison with cimetidine. In Misiewicz, J. J. and Wormsley, K. G. (eds.) The Clinical Use of Ranitidine. Proceedings of the Second International Symposium on Ranitidine 1982, pp. 163–167. ( Oxford: Medicine Publishing Foundation )

    Google Scholar 

  97. Witzel, L. and Wolberg, E. (1982). Peptic ulcer healing with ranitidine in cimetidine resistance. Lancet, 2: 1224

    Article  PubMed  CAS  Google Scholar 

  98. Bardhan, K. D. (1980). Cimetidine in duodenal ulcer: the present position. In Torsoli, A., Luchelli, P. E. and Brimblecombe, R. W. (eds.) Further Experience with H2 Receptor Antagonists in Peptic Ulcer Disease and Progress in Histamine Research, pp. 5–14 ( Amsterdam: Excerpta Medica )

    Google Scholar 

  99. Hunt, R. H. (1981). Non responders to cimetidine treatment part 1. In Baron, J. H. (ed.) Cimetidine in the 80’s, pp. 34–41. ( Edinburgh: Churchill Livingstone )

    Google Scholar 

  100. Gough, K. R., Korman, M. G., Bardhan, K. D. et al. (1984). Ranitidine and cimetidine in prevention of duodenal ulcer relapse. A double blind randomized multicentre comparative trial. Lancet, 2, 659–662

    Article  PubMed  CAS  Google Scholar 

  101. Roth, H. P. (1971). Healing of initial ulcers in relation of age and sex. Gastroenterology, 61, 570–575

    PubMed  Google Scholar 

  102. Jensen, K. B., Milmann, K. M., Rahbek, I. et al. (1979). Prophylactic effect of cimetidine in gastric ulcer patients. Scand. J. Gastroenterol., 14, 175–176

    Article  PubMed  CAS  Google Scholar 

  103. Machell, R. J., Ciclitira, P. J., Farthing, M. J. et al. (1979). Cimetidine in the prevention of gastric ulcer relapse. Postgrad. Med., 55, 393–395

    Article  CAS  Google Scholar 

  104. Cockel, R., Dawson, J. and Jain, S. (1982). Ranitidine in the long term treatment of gastric ulcers. In Misiewicz, J. J. and Wormsley, K. G. (eds.), The Clinical Use of Cimetidine, pp. 232–238. ( Oxford: Medicine Publishing Foundation )

    Google Scholar 

  105. Zamcheek, N., Grable, E., Ley, A. and Norman, L. (1955). Occurrence of gastric cancer among patients with pernicious anaémia at Boston City Hospital. N. Engl. J. Med., 252, 1103–1110

    Article  Google Scholar 

  106. Domellöf, L., Eriksson, S. and Janunger, K. G. (1977). Carcinoma and possible pre-cancerous changes of the gastric stump after Billroth II resection. Gastroenterology, 73, 462–468

    PubMed  Google Scholar 

  107. Tannenbaum, S. R. (1983). N-nitroso compounds: a perspective on human exposure. Lancet, 1, 629–632

    Article  PubMed  CAS  Google Scholar 

  108. Habs, M., Schmähl, D., Eisenbrand, G. and Preussmann, R. (1983). Carcinogenesis studies with N-nitrosocimetidine. In Magee, P. N. (ed.) Nitrosamines and Human Cancer, Banbury Report No. 12, pp. 403405. ( New York: Cold Spring Harbor Laboratory )

    Google Scholar 

  109. Lijinsky, W. (1982). Carcinogenesis studies with nitrosocimetidine. In Magee, P. N: (ed.) Nitrosamines and Human Cancer. Banbury Report No. 12, pp. 397–401, ( New York: Cold Spring Harbor Laboratory )

    Google Scholar 

  110. Colin Jones, D. G., Langman, M. J. S., Dawson, D. H. and Vessey, M.P. (1985). Postmarketing surveillance of the safety of cimetidine mortality during second, third and fourth years of follow-up. Br. Med. J., 291, 1084–1088

    Article  Google Scholar 

  111. Buck, J. P., Murgatroyd, R. E., Bolston, A. W. and Baron, J. H. (1979). Perforation of gastric carcinoma (at site of previous benign ulcer) after withdrawal of cimetidine. Lancet, 2, 42

    Article  PubMed  CAS  Google Scholar 

  112. Reed, P. I., Cassell, P. G. and Walters, C. L. (1979). Gastric cancer in patients who have taken cimetidine. Lancet, 1, 1234–1235

    PubMed  CAS  Google Scholar 

  113. Taylor, T. V., Lee, D., Howatson, A. G. et al. (1979). Gastric cancer and cimetidine. J. R. Coll. Surg. Edinburgh, 26, 34–35

    Google Scholar 

  114. Walan, A., Bergasker-Aspoy, J., Farup, P., et al. (1983). Four week study of the rate of duodenal ulcer healing with omeprazole. Gut, 24, A972

    Google Scholar 

  115. Lauritson, K., Rune, S. J., Bytzer, P. et al. (1985). Effect of omeprazole and cimetidine on duodenal ulcer. A double blind comparative trial. N. Engl. J. Med., 312, 958–961

    Article  Google Scholar 

  116. Nagashima, R. (1981). Mechanisms of action of sucralfate. J. Clin. Gastroenterol., 3 (Suppl. 2), 117–127

    PubMed  CAS  Google Scholar 

  117. Sasaki, H., Hinohara, Y., Tsunoda, Y. and Nagashima, R. (1983). Binding of sucralfate to duodenal ulcer in man. Scand. J. Gastroenterol., 18 (Suppl. 83) 13–14

    Google Scholar 

  118. McGraw, B. F. and Caldwell, E. G. (1981). Sucralfate. Drug Intel!. Clin. Pharm., 15, 578–580

    CAS  Google Scholar 

  119. Garnett, W. R. (1982). Sucralfate–alternative therapy for peptic ulcer disease. Clin. Pharm., 1, 307–314

    PubMed  CAS  Google Scholar 

  120. Samloff, I. M., O’Dell, C. (1985). Inhibition of peptic activity by sucralfate. Am. J. Med., 79: (Suppl. 2c) 15–18

    Article  PubMed  CAS  Google Scholar 

  121. Fixa, B. and Komârkovâ, O. (1981). Aluminium sucrose sulphate (sucralfate) in the treatment of peptic ulcer (double blind study). In Caspary, W. F. (ed.) Sucralfate: A New Therapeutic Concept, pp. 8084, ( Baltimore: Urban and Schwarzenberg )

    Google Scholar 

  122. McHardy, G. G. (1981). A multicentre double blind trial of sucralfate and placebo in duodenal ulcer. J. Clin. Gastroenterol., 3, (Suppl. 2) 147–152

    Article  PubMed  CAS  Google Scholar 

  123. Tytgat, G. N.J., Hameeteman, W., Van Olffen, G. H. (1984). Miscellaneous Drugs. In Isenberg, J. I. and Johansson, C. (eds.), Peptic Ulcer Disease,Clinics in Gastroenterology, pp. 543–568, (London: W. B. Saunders)

    Google Scholar 

  124. Brandstaetter, G. and Kratochvil, P. (1985). Comparison of sucralfate dosages (2 g twice a day versus 1 g four times a day) in duodenal ulcer healing. Am. J. Med., 79: (Suppl. 2c) 36–38

    Article  PubMed  CAS  Google Scholar 

  125. Marks, I. N., Wright, J. P., Denyer, M. et al. (1980). Comparison of sucralfate with cimetidine in the short-term treatment of chronic peptic ulcer. S. Afr. Med. J. 57, 567–573

    PubMed  CAS  Google Scholar 

  126. Lahtinen, J., Ankee, S., Miettinen, P. et al. (1983). Sucralfate and cimetidine for gastric ulcer. Scand. J. Gastroenterol., 18, (Suppl. 83) 49–51

    Google Scholar 

  127. Classen, M., Bethge, H., Brunner, G. et al. (1982). Sucralfate prevents duodenal ulcer recurrences. A controlled double blind study. Gastroenterology, 82, 1034

    Google Scholar 

  128. Libeskind, M. (1982). Maintenance treatment of patients with healed peptic ulcer with sucralfate, placebo and cimetidine. Scand. J. Gastroenterol., 18, (Suppl. 83) 69–70

    Google Scholar 

  129. Marks, I. N., Wright, J. P., Girdwood, A. H. et al. (1985). Maintenance therapy with sucralfate reduces rate of gastric ulcer recurrence. Am. J. Med., 79 (Suppl. 2c) 32–35

    Article  PubMed  CAS  Google Scholar 

  130. Lee, S. P. (1982). A potential mechanism of action of colloidal bismuth subcitrate: diffusion barrier to hydrochloric acid. Scand. J. Gastroenterol., 17, (Suppl. 80) 17–21

    CAS  Google Scholar 

  131. Brogden, R.N., Pinder, R.M., Sawyer, P. R. et al. (1976). Tri-potassium dicitratobismuthate: a report of its pharmacological properties and therapeutic efficacy in peptic ulcer. Drugs, 12, 401–411

    Article  PubMed  CAS  Google Scholar 

  132. Boyes, B. E., Woolf, I. L., Wilszn, R. Y. et al. (1975). Treatment of gastric ulceration with a bismuth preparation. Postgrad. Med. J.,51 (Suppl. 5) 29–32

    Google Scholar 

  133. Lee, S. P. and Nicholson, G. I. (1977). Increased healing of gastric and duodenal ulcer in a controlled trial using tripotassium dicitratobismuthate. Med. J. Aust., 1, 808–812

    PubMed  CAS  Google Scholar 

  134. Tytgat, G. N. J., Van. Bentem, N. Van Olffen, G. et al. (1982). Controlled trial comparing colloidal bismuth subcitrate tablets, cimetidine and placebo in the treatment of gastric ulceration. Scand. J. Gastroenterol., 17, (Suppl. 80) 31–38

    Google Scholar 

  135. Martin, D.F., Hollanders, D., May, S.J. et al. (1981). Difference in relapse rates of duodenal ulcer after healing with cimetidine or tripotassium dicitratobismuthate. Lancet, 1, 7–10

    Article  PubMed  CAS  Google Scholar 

  136. Lee, F.I., Samloff, T. M. and Hardman, M. (1985). Comparison of tripotassium dicitratobismuthate tablets with ranitidine in healing and relapse of duodenal ulcers. Lancet, 1, 1229–1230

    Google Scholar 

  137. Kang, J. Y. and Piper, D. N., (1982). Cimetidine and colloidal bismuth in the treatment of chronic duodenal ulcer: comparison of initial healing and recurrence after healing. Digestion, 23, 73–79

    Article  PubMed  CAS  Google Scholar 

  138. Archambault, A. P., Halvorsen, L., Lee, S. P. et al. (1984). Efficacy and safety of enprostil, a synthetic prostaglandin and placebo in patients with duodenal ulcer. Am. J. Gastroenterol., 79, 828

    Google Scholar 

  139. Lauritsen, K., Laursen, L. S., Havelund, T. et al. (1986). Effect of enprostil and ranitidine on duodenal ulcer healing. Gut, 27, A608

    Google Scholar 

  140. Walt, R. P., Long, R. G., Logan, R. F. A. et al. (1986). Double blind clinical trial comparing night time enprostil with ranitidine in duodenal ulcer. Gut, 27, A608

    Google Scholar 

  141. Sontag, S., Graham, D. Y., Belsito, A. et al. (1984). Cimetidine, cigarette smoking and recurrence of duodenal ulcer. N. Engl. J. Med., 311, 689–693

    Article  PubMed  CAS  Google Scholar 

  142. Cumberland, D. C. (1975). Fibreoptic endoscopy and radiology in the investigation of the upper gastrointestinal tract. Clin. Radiol., 26, 223236

    Google Scholar 

  143. Barnes, R. J., Gear, M. W. L., Nicol, A. and Drew, A. B. (1974). Study of dyspepsia in a general practice as assessed by endoscopy and radiology. Br. Med. J., 4, 214–216

    Article  PubMed  CAS  Google Scholar 

  144. Laufer, I., Mullens, J. E. and Hamilton, J. (1975). The diagnostic accuracy of barium studies of the stomach and duodenum–correlation with endoscopy. Radiology, 115, 569–573

    PubMed  CAS  Google Scholar 

  145. Shirakabe, H., Nishizawa, M., Nomoto, K. et al. (1975). Qualitative comparison of endoscopy and radiology in the diagnosis of duodenal ulcer. Gastroenterology, 68, 1031

    Google Scholar 

  146. Fraser, G. M. and Earnshaw, P. M. (1983). The double contrast barium meal: a correlation with endoscopy. Clin. Radiol., 34, 121–131

    Article  PubMed  CAS  Google Scholar 

  147. Cotton, P. B. and Shorvon, P. J. (1984). Endoscopy and radiology in peptic ulcer disease. In Isenberg, J. I. and Johansson, C. (eds.), Peptic Ulcer Disease, Clinics in Gastroenterology, pp. 383–403, ( London: W. B. Saunders )

    Google Scholar 

  148. Farin, R., Farinati, F., Cardin, F. et al. (1983). Evidence of gastric carcinoma during follow-up of apparently benign gastric ulcer. Gut, 24, A486

    Google Scholar 

  149. Schiller, K. F. R. and Prout, B. J. (1976). Hazards. In Schiller, K. F. R. and Salmon, P. R. (eds.) Modern Topics in Gastrointestinal Endoscopy, pp. 147–165, ( London: William Heinemann Medical )

    Google Scholar 

  150. Holdstock, C. D., Bardhan, K. D. and Balmforth, G. V. (1979). Upper gastrointestinal endoscopy: its effect on patient management. Br. Med. J., 1, 775–777

    Article  Google Scholar 

  151. Lance, P. and Gazzard, B. G. (1983). Controlled trial of cimetidine for symptomatic treatment of duodenal ulcers. Br. Med. J., 286, 937–938

    Article  CAS  Google Scholar 

  152. Bardhan, K. D. (1980). Intermittent treatment of duodenal ulcer with cimetidine. Br. Med. J., 2, 20–22

    Article  Google Scholar 

  153. Rune, S. J., Mollman, K. M. and Rahbek, J. (1980). Frequency of relapses in duodenal ulcer patients treated with cimetidine during symptomatic periods. Scand. J. Gastroenterol., 15 (Suppl. 58) 85–92

    Google Scholar 

  154. Fry, J. (1964). Peptic ulcer: a profile. Br. Med. J., 2, 809–812

    Article  PubMed  CAS  Google Scholar 

  155. Kraus, E. (1963). Long term results of medical and surgical treatment. A follow-up investigation of patients initially treated conservatively between 1925 and 1934. Acta. Chir. Scand. (Suppl. 310 ).

    Google Scholar 

  156. Viskum, K. (1976). A comparison of the course of the disease among patients with gastric ulcer, duodenal ulcer and ulcer dyspepsia without ulcer demonstrable by X-ray. Dan. Med. Bull., 23, 129–136

    PubMed  CAS  Google Scholar 

  157. Mazzaca, G., D’Agostino, L., D=Arienzo, A. et al. (1982). Cimetidine or ranitidine non-responder patients. Treatment of duodenal ulcers resistant to one H2 blocker with the other. Scand. J. Gastroenterol., 17 (Suppl. 78), 103 (abstract 408)

    Google Scholar 

  158. Lam, S. K., Lee, N. W., Koo, J. et al. (1984). Randomized crossover trial of tripotassium dicitratobismuthate versus high dose cimetidine for duodenal ulcers resistant to standard dose of cimetidine. Gut,25, 703

    Google Scholar 

  159. Bardhan, K. D., Thompson, M., Bose, K. et al. (1986). Combined histamine H2 and antimuscarinic receptor blockade in the treatment of refractory duodenal ulcer. Gut, 27, A606

    Google Scholar 

  160. Gustaysson, S., Adami, H. O., Lööf, A. et al. (1983). Rapid healing of duodenal ulcers with omeprazole: a double blind dose-comparative trial. Lancet, 2, 124–125

    Article  Google Scholar 

  161. Gear, M. W. L. (1986). The place of surgery in the management of peptic ulcer. A comparison with modern drug therapy. In Lancaster Smith, M. J. (ed.) Peptic Ulcer, Seminar, pp. 13–22 ( London: Update Siebart Publications )

    Google Scholar 

  162. Fineberg, H. V. and Pearlman, L. A. (1981). Surgical treatment of peptic ulcer in the United States. Trends after the introduction of cimetidine. Lancet, 1, 1305–1308

    Article  PubMed  CAS  Google Scholar 

  163. Wastell, C. (1982). The stomach and duodenum. In Bouchier, I.A.D. (ed.) Recent Advances in Gastroenterology, 33 ( Edinburgh: Churchill Livingstone )

    Google Scholar 

  164. Johnston, D. (1975). Operative mortality and morbidity of highly selective vagotomy, 4, 545–547

    CAS  Google Scholar 

  165. Clark, C. G. (1982). Recurrent ulcer. In Barron, J. H., Alexander-Williams, J., Allgower, M., Muller, C. and Spencer, J. (eds.) Vagotomy in Modern Surgical Practice, pp. 305–332 ( London: Butterworths )

    Google Scholar 

  166. Kennedy, T. L. (1982). Recurrent ulcer. In Barron, J. H., Alexander-Williams, J., Allgower, M., Muller, C. and Spencer, J. (eds.) Vagotomy in Modern Surgical Practice, pp. 327–329 ( London: Butterworths )

    Google Scholar 

  167. Kelly, K. A. and Malagelada, J. R. (1984). Medical and surgical treatment of chronic gastric ulcer. In Isenberg, J. I. and Johansson, C. (eds.) Peptic Ulcer, Clinics in Gastroenterology, pp. 621–634 ( London: W. B. Saunders )

    Google Scholar 

  168. Duthie, H. L. and Kwong, N. K. (1973). Vagotomy or gastrectomy for gastric ulcer. Br. Med. J., 4, 79–81

    Article  PubMed  CAS  Google Scholar 

  169. Poppen, B. and Delin, A. (1981). Parietal cell vagotomy for duodenal and pyloric ulcers. I. Clinical factors leading to failure of the operation. Am. J. Surg., 141, 323–329

    Article  PubMed  CAS  Google Scholar 

  170. Barron, J.H., Barr, J., Batten, J., Sidebottom, R. and Spencer, J. (1986). Acid, pepsin and mucus secretion in patients with gastric and duodenal ulcer before and after colloidal bismuth Subcitrate (Denol). Gut, 27, 486–490

    Article  Google Scholar 

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  1. Queen Mary’s Hospital, Sidcup, Kent, UK

    M. Lancaster-Smith (Consultant Gastroenterologist) (Consultant Gastroenterologist)

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Lancaster-Smith, M. (1987). Peptic Ulcer. In: Lancaster-Smith, M. (eds) Ulcer and Non-Ulcer Dyspepsias. Practical Clinical Medicine. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-9928-8_3

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