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Oesophagitis

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Ulcer and Non-Ulcer Dyspepsias

Part of the book series: Practical Clinical Medicine ((PCLM))

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Abstract

Oesophagitis is one of the commonest gastrointestinal disorders and is encountered by both general practitioners and hospital specialists alike. Its principal symptom is retrosternal burning pain or ‘heartburn’ which results from the reflux of gastric acid into the oesophagus causing mucosal inflammation (reflux oesophagitis). In many patients reflux will not be severe enough to cause inflammatory changes in the mucosa but will be sufficient to cause symptoms and the term ‘reflux disease’ is often used to refer to this more general condition.

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References

  1. Nebel, O. T., Formes, M. F. and Castell, D. O. (1976). Symptomatic gastro-oesophageal reflux: incidence and precipitating factors. Am. J. Dig. Dis., 21, 953–956

    Article  PubMed  CAS  Google Scholar 

  2. Edwards, D. A. W. (1984). Physiology of the oesophagus. In Bouchier, I. A. D., Allan, R. N., Hodgson, H. J. F., Kieghley, M. R. B. (eds.) Textbook of Gastroenterology, pp. 18–25. ( London: Baillière-Tindall )

    Google Scholar 

  3. Dyer, M. H. and Pridie, R. B. (1968). Incidence of hiatus hernia in asymptomatic subjects. Gut, 9, 696–699

    Article  PubMed  CAS  Google Scholar 

  4. Dent, J., Dodds, W.J. and Friedman, R. H. (1980). Mechanism of gastro-oesophageal reflux in recumbent asymptomatic human subjects. J. Clin. Invest, 65, 256–267.

    Article  PubMed  CAS  Google Scholar 

  5. Dodds, W.J., Dent, J. and Hogan, W.J. (1978). Pregnancy and the lower oesophageal sphincter. Gastroenterology, 74, 1334–1335

    PubMed  CAS  Google Scholar 

  6. Van Thiel, D. H., Gavalier, J. S. and Stremple, J. F. (1979). Lower oesophageal sphincter pressure during the normal menstrual cycle. Am. J. Obstet. Gynecol., 134, 64–67

    PubMed  Google Scholar 

  7. Demish, G. W. and Castell, D. O. (1971) Inhibitory effect of smoking on the lower oesophageal sphincter. N. Eng. J. Med., 284, 1136–1137.

    Article  Google Scholar 

  8. Nebel, O. T. and Castell, D.O. (1972). Lower oesophageal sphincter changes after food ingestion. Gastroenterology, 63, 778–783

    PubMed  CAS  Google Scholar 

  9. Cohen, S., Fisher, R. and Lipschutz, W. (1972). The pathogenesis of oesophageal dysfunction in sclerodema and Raynaud’s Disease. J. Clin. Invest., 51, 2663–2668

    Article  PubMed  CAS  Google Scholar 

  10. Vantrappen, G. and Hellemans, J. (1980). Treatment of achalasia and related disorders. Gastroenterology, 79, 144–154

    PubMed  CAS  Google Scholar 

  11. Chung, R. S., Johnson, G. M. and Den Besten, L. (1977). Effect of sodium taurocholate and ethanol on hydrogen ion absorption in rabbit oesophagus. Am. J. Dig. Dis., 22, 582–588

    Article  PubMed  CAS  Google Scholar 

  12. Hamon, J. W., Johnson, L. F. and Maydonovitch, C. L. (1981). Effects of acid bile salts on the rabbit oesophageal mucosa. Dig. Dis. Sci., 26, 65–72

    Article  Google Scholar 

  13. Booth, D. J., Kemmerer, W. D. and Skinner, D. B. (1968). Acid clearing from the distal oesophagus. Arch. Surg., 76, 732–734

    Google Scholar 

  14. Orr, W. C., Johnson, L. F. and Robinson, M. G. (1984). Effects of sleep on swallowing, esophageal peristalsis and acid clearance. Gastroenterology, 86, 814–819

    PubMed  CAS  Google Scholar 

  15. Bennett, J. R. (1984). Oesophagitis. In Bouchier, I. A. D., Allan, R. W., Hodgson, H. J. F. and Kieghley, M. R. B. (eds.) Textbook of Gastroenterology. pp. 40–50. ( London: Baillière-Tindall )

    Google Scholar 

  16. McCallum, R.W., Berkowitz, D.M. and Lewar, E. (1981). Gastric emptying in patients with gastroesophageal reflux. Gastroenterology, 80, 285–291

    PubMed  CAS  Google Scholar 

  17. Bennett, J. R. (1983). Chest pain–heart or gullet? Br. Med. J., 286, 1231–1232

    Article  CAS  Google Scholar 

  18. Barrett, N. R. (1957). The lower oesophagus lined by columnar epithelium. Surgery, 41, 881–894

    PubMed  CAS  Google Scholar 

  19. Sarr, M. G., Hamilton, S. R., Marrone, G. C. and Cameron, J. L. (1985). Barrett’s oesophagus: its prevalence and association with adenocarcinoma in patients with symptoms of gastroesophageal reflux. Am. J. Surg., 149, 187–193

    Article  PubMed  CAS  Google Scholar 

  20. Cameron, A. J. C., Orr, B. J. and Payne, W. S. (1985). The incidence of adenocarcinoma in columnar-lineal (Barrett’s) esophagus. N. Engl. J. Med., 313, 857–859

    Article  PubMed  CAS  Google Scholar 

  21. Cohen, S. and Harris, L. D. (1971). Does hiatus hernia affect competence of the gastroesophageal sphincter? N. Engl. J. Med., 284, 1053–1056

    Article  PubMed  CAS  Google Scholar 

  22. Richter, J. E. and Castell, D. O. (1982). Gastroesophageal Reflux: Pathogenesis, Diagnosis and Therapy. Ann. Intern. Med., 97, 93–103

    PubMed  CAS  Google Scholar 

  23. Ott, D.J., Wu, W.C. and Gelford, D. W. (1981). Reflux esophagitis revisited: prospective analysis of radiographic accuracy. Gastroint. Radiol., 6, 1–7

    Article  CAS  Google Scholar 

  24. Ismail-Beigi, F., Horton, P. F. and Pope, C. E. (1970). Histological consequences of gastroesophageal reflux in man. Gastroenterology, 58, 163–174

    PubMed  CAS  Google Scholar 

  25. Ismail-Beigi, F. and Pope, C. E. (1974). Distribution of the histological changes of gastroesophageal reflux in the distal oesophagus of man. Gastroenterology, 66, 1109–1113

    PubMed  CAS  Google Scholar 

  26. Knuff, T. E., Benjamin, S. B., Worsham, G. F., Hancock, J. E. and Castell, D. O. (1984). Histologic evaluation of chronic gastroesophageal reflux. An evaluation of biopsy methods and diagnostic criteria. Dig. Dis. Sci., 29, 194–201

    Article  PubMed  CAS  Google Scholar 

  27. Branicki, F. J., Evans, D. F., Ogilvie, A. L., Atkinson, M. and Hard-castle, J. D. (1982). Ambulatory monitoring of oesophageal pH in reflux oesophagitis using a portable radiotelemetry system. Gut, 23, 992–998

    Article  PubMed  CAS  Google Scholar 

  28. Johnson, L. F. and Demeester, T. R. (1981). Evaluation of elevation of the head of the bed, bethanechol and antacid foam tablets on gastroesophageal reflux. Dig. Dis. Sci., 26, 673–680

    Article  PubMed  CAS  Google Scholar 

  29. Lloyd, D. A. and Borda, I. T. (1978). Food-induced heartburn: effect of osmolarity. Gastroenterology, 75, 240–243

    Google Scholar 

  30. Thomas, K. B., Stembaugh, J. T., Fromkes, J. J., Mekhjian, H. S. and Callwell, J. H. (1980). Inhibitory effect of coffee on lower esophageal sphincter pressure. Gastroenterology, 79, 1262–1266

    PubMed  CAS  Google Scholar 

  31. Demmish, G. W. and Castell, D. O. (1971). Inhibitory effect of smoking on the lower esophageal sphincter. N. Engl. J. Med., 284, 1136–1137

    Article  Google Scholar 

  32. Castell, D. O. and Levine, S. M. (1971). Lower oesophageal sphincter response to alkalinization. A new mechanism for treatment of heartburn with antacids. Ann. Intern. Med., 74, 223–227

    PubMed  CAS  Google Scholar 

  33. Serebro, H. A., Friedman, M. and Beck, I. T. (1973). Efficacy of continuous intra-oesophageal antacid drip therapy in the treatment of reflux oesophagitis. South Afr. Med. J., 47, 1656–1659

    CAS  Google Scholar 

  34. Behar, J., Sheaham, D. G., Biancani, P., Spiro, H. M. and Storer, E. H. (1975). Medical and surgical management of reflux oesophagitis. N. Engl. J. Med., 293, 263–268

    Article  PubMed  CAS  Google Scholar 

  35. Stanciui, C. and Bennett, J. R. (1974). Alginate/antacid in the reduction of gastro-oesophageal reflux. Lancet, 109–111

    Google Scholar 

  36. Graham, D. Y., Lanza, F. and Dorsch, E. R. (1977). Symptomatic reflux oesophagitis: a double-blind controlled comparison of antacids and alginate. Curr. Ther. Res., 22, 653–658

    Google Scholar 

  37. Farrell, R. L., Roling, G. T. and Castell, D. O. (1974). Cholinergic therapy of chronic heartburn. Ann. Intern. Med., 8, 573–576

    Google Scholar 

  38. Stanciu, C. and Bennett, J. R. (1973). Metoclopramide in gastroesophageal reflux. Gut, 14, 275–279

    Article  PubMed  CAS  Google Scholar 

  39. McCallum, R. W., Ippoliti, A. F., Cooney, C. and Sturdevant, R. A. L. (1977). A controlled trial of metoclopramide in symptomatic gastroesophageal reflux. N. Engl. J. Med., 296, 354–357

    Article  PubMed  CAS  Google Scholar 

  40. Bennett, J. R., Martin, H. D. and Buckton, G. (1980). Cimetidine in reflux oesophagitis. In: Hepato-Gastroenterology Supplement. Abstracts of the XI. International Congress of Gastroenterology. June 813, Hamburg, p. 30.

    Google Scholar 

  41. Tytgat, G. N.J. (1981). Assessment of the efficacy of cimetidine and other drugs in oesophageal reflux disease. In Baron, J. H. (ed.) Cimetidine in the 80’s. pp. 153–166. ( Edinburgh: Churchill Livingstone )

    Google Scholar 

  42. Mahachai, V., Walker, K. and Thomson, A. B. R. (1985). Comparison of cimetidine and ranitidine on 24-hour intragastric acidity and serum gastrin profile in patients with esophagitis. Dig. Dis. Sci., 30, 321–328

    Article  PubMed  CAS  Google Scholar 

  43. Watson, A. (1984). The role of antireflux surgery combined with fibre-optic endoscopic dilatation in peptic esophageal stricture. Am. J. Surg., 148, 346–349

    Article  PubMed  CAS  Google Scholar 

  44. Dawson, J. and Cochel, R. (1981). Oesophageal perforation at fibreoptic gastroscopy. Br. Med. J., 1, 283–285

    Google Scholar 

  45. Lee, M., Ravenscroft, M. M., Green, J. R. B. and Swan, C. H. J. (1983). Safe outpatient dilatation of benign oesophageal strictures. Gut, 24, A1008

    Google Scholar 

  46. Wesdorp, I. C. E., Bartelsman, J., Schipper, M. E. I. and Tytgat, G. N. (1981). Effect of long-term treatment with cimetidine and antacids in Barrett’s oesophagus. Gut, 22, 724–727

    Article  PubMed  CAS  Google Scholar 

  47. Brand, D. L., Ylvisakes, J. T., Gelfand, M. and Pope, C. E. (1980). Regression of columnar esophageal (Barrett’s) epithelium after anti-reflux surgery. N. Engl. J. Med., 302, 844–848

    Article  PubMed  CAS  Google Scholar 

  48. Jamieson, G. G. and Duranceau, A. (1984). What is a Nissen fundoplication? Surg. Gynaecol. Obstet., 159, 591–596

    CAS  Google Scholar 

  49. Polk, H. C. (1976). Fundoplication for reflux esophagitis. Ann. Surg., 183, 645–682

    Article  PubMed  Google Scholar 

  50. Gear, M. L. W. (1985). In Jewell, D. P. and Chapman, R. W. (eds.) Topics in Gastroenterology. pp. 135–145. ( Oxford: Blackwell Scientific Publications )

    Google Scholar 

  51. Angelchik, J. P. and Cohen, R. (1979). A new surgical procedure for the treatment of gastroesophageal reflux and hiatal hernia. Surg. Gynaecol. Obstet., 148, 246–248

    CAS  Google Scholar 

  52. Pickleman, J. (1983). Disruption and migration of an Angelchik esophageal anti-reflux prosthesis. Surgery, 93, 467

    PubMed  CAS  Google Scholar 

  53. Washer, G. F., Gear, M. W. L., Dowling, B. L., Gillison, E. W., Royston, C. M. S. and Spencer, J. (1984). Randomized prospective trial of Roux-en-Y duodenal diversion versus fundoplication for severe reflux esophagitis. Br. J. Surg., 71, 181

    Article  PubMed  CAS  Google Scholar 

  54. Wesdorp, I. C. E., Dekker, W. and Klinkenberg-Knol, E. C. (1983). Treatment of reflux oesophagitis with ranitidine. Gut, 24, 921–924

    Article  PubMed  CAS  Google Scholar 

  55. Laitinen, S., Stahlberg, M., Kairaluoma, M., Kivinienn, H., Paakkonen, M., Lahtinen, J., Poikolainen, E. and Ankee, S. (1985). Sucralfate and alginate/antacid in reflux esophagitis. Scand. J. Gastroenterol., 20, 229–232

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. A. J. M. Watson
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  2. M. J. G. Farthing
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Editors and Affiliations

  1. Queen Mary’s Hospital, Sidcup, Kent, UK

    M. Lancaster-Smith (Consultant Gastroenterologist) (Consultant Gastroenterologist)

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© 1987 MTP Press Limited

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Watson, A.J.M., Farthing, M.J.G. (1987). Oesophagitis. In: Lancaster-Smith, M. (eds) Ulcer and Non-Ulcer Dyspepsias. Practical Clinical Medicine. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-9928-8_2

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  • DOI: https://doi.org/10.1007/978-94-010-9928-8_2

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-0-85200-691-7

  • Online ISBN: 978-94-010-9928-8

  • eBook Packages: Springer Book Archive

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