Abstract
The pregnant uterus, as a viscus, behaves in a peculiar way, in that it accommodates for a considerable length of time a large foreign body in its cavity. During the greater part of gestation, myometrial contractions are infrequent and of low intensity. Possibly, the slow and very gradual distension of the muscle wall by the growing conceptus prevents up to a point the appearance of trains of contractions leading to expulsion of the latter. Much more likely, however, the quiescence of the normal pregnant uterus is achieved by an extrinsic mechanism of neuroendocrine nature.
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References
Amy, J. J. and Karim, S. M. M. (1978). Prostaglandins and other oxytocic substances in amniotic fluid. In Fairweather, D. V. I. and Eskes, T. K. A. B. (eds.) Amniotic Fluid—Research and Clinical Application. 2nd Edn., pp. 321–345. ( Amsterdam: Excerpta Medica )
Amy, J. J. and Thiery, M. (1980). Labor — spontaneous and induced. In Aladjem, S., Brown, A. K. and Sureau, C. (eds.) Clinical Perinatology. 2nd Edn., pp. 362–381. ( St Louis: Mosby )
Anderson, A. (1980). The genital system. In Hytten, F. and Chamberlain, G. (eds.) Clinical Physiology in Obstetrics, pp. 328–380. ( Oxford: Blackwell Scientific )
Boroditsky, R. S., Reyes, F. I., Winter, J. S. D. and Faiman, C. (1978). Maternal serum estrogen and progesterone concentrations preceding normal labor. Obstet, Gynecol., 51, 686
Calder, A. A. (1979). Management of the unripe cervix. In Keirse, M. J. N. C., Anderson, A. B. M. and Bennebroek Gravenhorst, J. (eds.) Human Parturition, pp. 201–217. ( Leiden: Leiden University Press )
Campbell, A. L. and Murphy, B. E. P. (1977). The maternal-fetal cortisol gradient during pregnancy and at delivery. J. Clin. Endocrinol. Metab., 45, 435
Carsten, M. E. (1976). How does calcium control uterine contraction? Contemp. Obstet. Gynecol., 8, 61
Carsten, M. E. (1979). Calcium accumulation by uterine microsomal preparations: Effects of progesterone and oxytocin. Am. J. Obstet. Gynecol., 133, 598
Chard, T., Silman, R. E. and Rees, L. H. (1977). The fetal hypothalamus and pituitary in the initiation of labour. In Knight, J. and O’Connor, M. (eds.) Ciba Foundation Symposium 47: The Fetus and Birth, pp. 359–370. ( Amsterdam: Elsevier/North Holland/Excerpta Medica )
Csapo, A. I. (1977). The `see-saw’ theory of parturition. In Knight, J. and O’Connor, M. (eds.) Ciba Foundation Symposium 47: The Fetus and Birth, pp. 159–195. (Amsterdam. Elsevier/North Holland/Excerpta Medica)
Dawood, M. Y., Wang, C. F., Gupta, R. and Fuchs, F. (1978). Fetal contribution to oxytocin in human labor. Obstet. Gynecol., 52, 205
Ellwood, D. A., Anderson, A. B. M., Mitchell, M. D., Murphy, G. and Turnbull, A. C. (1981). Prostanoids, collagenase and cervical softening in the sheep. In Ellwood, D. A. and Anderson, A. B. M. (eds.) The Cervix in Pregnancy and Labour, pp. 57–73. ( Edinburgh: Churchill Livingstone )
Flint, A. P. F., Forsling, M. L. and Mitchell, M. D. (1978). Blockade of the Ferguson reflex by lumbar epidural anaesthesia in the parturient sheep: Effects of oxytocin secretion and uterine venous prostaglandin F levels. Horm. Metab. Res., 10, 545
Forman, A., Andersson, K. E. and Ulmsten, U. (1981). Inhibition of myometrial activity by calcium antagonists. Semin. Perinatol., 5, 288
Fuchs, A. R., Fuchs, F., Husslein, P., Soloff, M. S. and Fernström, M. J. (1982). Oxytocin receptors and human parturition: A dual role for oxytocin in the initiation of labor. Science, 215, 1396
Garfield, R. E. and Hayashi, R. H. (1981): Appearance of gap junctions in the myometrium of women during labor. Am. J. Obstet. Gynecol., 140, 254
Garrioch, D. B. (1978). The effect of indomethacin on spontaneous activity in the isolated human myometrium and on the response to oxytocin and prostaglandin. Br. J. Obstet. Gynaecol., 85, 47
Gennser, G., Orhlander, S. and Aneroth, P. (1977). Fetal cortisol and the initiation of labour in the human. In Knight, J. and O’Connor, M. (eds.) Ciba Foundation Symposium 47: The Fetus and Birth, pp. 401–420. ( Amsterdam: Elsevier/North Holland/Excerpta Medica )
Haning, R. V. Jr., Barrett, D. A., Alberino, S. P., Lynskey, M. T., Donabedian, R. and Speroff, L. (1978). Interrelationships between maternal and cord prolactin, progesterone, estradiol, 13,14dihydro-15-keto-prostaglandin Fla, and cortisol at delivery with respect to initiation of parturition. Am. J. Obstet. Gynecol., 130, 204
Harbon, S., Do Khac, L., Vesin, M. F. and Leiber, D. (1979). Etude des mécanismes d’action des prostaglandines dans la régulation de la contractilité du muscle utérin. In Amy, J. J. (ed.) Les Prostaglandines et la Reproduction Humaine, pp. 27–46. ( Paris: Flammarion Médecine-Sciences )
Huszar, G. (1981). Biology and biochemistry of myometrial contractility and cervical maturation. Semin. Perinatol., 5, 216
Jacobs, H. S. (1980): Hypothalamus and pituitary gland. In Hytten, F. and Chamberlain, G. (eds.) Clinical Physiology in Obstetrics, pp. 383–399. ( Oxford: Blackwell Scientific Publications )
Johnson, J. W., Lee, P. A., Zachary, A. S., Calhoun, S. and Migeon, C. J. (1979). High risk prematurity—progestin treatment and steroid studies. Obstet. Gynecol., 54, 412
Kauppila, A., Hartikainen-Sorri, A. L., Jänne, O. Tuimala, R. and Järvinen, P. A. (1980). Suppression of threatened premature labor by administration of cortisol and 17a-hydroxyprogesterone caproate: A comparison with ritodrine. Am. J. Obstet. Gynecol., 138, 404
Keirse, M. J. N. C. (1979): Prostaglandines et déclenchement spontané du travail. In Amy, J. J. (ed.) Les Prostaglandines et la Reproduction Humaine, pp. 107–140. (Paris: Flammarion Médecine-Sciences)
Krall, J. F., Mori, H. and Korenman, S. G. (1977). Molecular basis of drug action on uterine smooth muscle. In Anderson, A., Beard, R., Brudenell, J. M. and Dunn, P. M. (eds.) Pre-Term Labour, pp. 79–100. ( London: Royal College of Obstetricians and Gynaecologists. )
Liggins, J. C., Forster, C. S., Grieves, S. A. and Schwartz, A. L. (1977). Control of parturition in man. Biol. Reprod., 16, 39
MacKenzie, I. Z. (1981). Clinical studies on cervical ripening. In Ellwood, D. A. and Anderson, A. B. M. (eds.) The Cervix in Pregnancy and Labour, pp. 162–186. (Edinburgh: Churchill Livingstone)
MacKenzie, I. Z., Jenkin, G. and Bradley, S. (1979). The relation between plasma oestrogen, progesterone and prolactin concentrations and the efficacy of vaginal prostaglandin EZ gel in initiating labour. Br. J. Obstet. Gynaecol., 86, 171
von Maillot, K., Stuhlsatz, H. W. and Gentsch, H. H. (1981). Connective tissue changes in the human cervix in pregnancy and labour. In Ellwood, D. A. and Anderson, A. B. M. (eds.) The Cervix in Pregnancy and Labour, pp. 123–135. ( Edinburgh: Churchill Livingstone )
Mathur, R. S., Landgrebe, S. and Williamson, H. O. (1980). Progesterone, 17-hydroxyprogesterone, estradiol, and estriol in late pregnancy and labor. Am. J. Obstet. Gynecol., 136, 25
Okazaki, T., Okita, J. R., MacDonald, P. C. and Johnston, J. M. (1978). Initiation of human parturition. X. Substrate specificity of phospholipase AZ in human fetal membranes. Am. J. Obstet. Gynecol., 130, 432
Porter, D. G. (1981). Relaxin and cervical softening: a review. In Ellwood, D. A. and Anderson, A. B. M. (eds.) The Cervix in Pregnancy and Labour, pp. 85–99. ( Edinburgh: Churchill Livingstone )
Pritchard, J. A. and MacDonald, P. C. (1980). Williams Obstetrics. 16th Edn. ( New York: Appleton-Century-Crofts )
Ryan, K. J. (1977). New concepts in hormonal control of parturition. Biol. Reprod., 16, 88
Schwarz, B. E., Milewich, L., Johnston, J. M., Porter, J. C. and MacDonald, P. C. (1976). Initiation of human parturition. V. Progesterone binding substance in fetal membranes. Obstet. Gynecol., 48, 685
Silman, R. E., Chard, T., Lowry, P. J., Mullen, P. E., Smith, I. and Young, I. M. (1977). Human fetal corticotropin and released pituitary peptides. J. Steroid Biochem., 8, 553
Soloff, M. S. (1976). Uterine receptors for oxytocin: Correlation between antagonist potency and receptor binding. Br. J. Pharmacol., 57, 381
Swaab, D. F., Boer, K. and Honnebier, W. J. (1977). The influence of the fetal hypothalamus and pituitary on the onset and course of parturition. In Knight, J. and O’Connor, M. (eds.) Ciba Foundation Symposium 47: The Fetus and Birth, pp. 379–393. ( Amsterdam: Elsevier/North Holland/Excerpta Medica )
Thiery, M., De Gezelle, H. Van Kets, H., Voorhoof, L., Verheugen, C., Smis, B., Gerris, J., Derom, R. and Martens, G. (1979). The effect of locally administered estrogens on the human cervix. Z. Geburtsh. Perinat., 183, 448
Uldbjerg, N., Ekman, G., Malmström, A., Sporrong, B., Ulmsten, U. and Wingerup, L. (1981). Biochemical and morphological changes of human cervix after local application of prostaglandin EZ in pregnancy. Lancet, 1, 267
Vasicka, A, Kumaresan, P., Han, G. S. and Kumaresan, M. (1978). Plasma oxytocin in initiation of labor. Am. J. Obstet. Gynecol., 130, 263
Whalley, E. T. (1978). The action of bradykinin and oxytocin on the isolated whole uterus and myometrium of the rat in oestrus. Br. J. Pharmacol., 64, 21
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Amy, J.J., De Brucker, P., Merckx, M. (1984). Control of uterine activity in pregnancy. In: Hafez, E.S.E. (eds) Spontaneous Abortion. Advances in Reproductive Health Care, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-9789-5_3
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DOI: https://doi.org/10.1007/978-94-010-9789-5_3
Publisher Name: Springer, Dordrecht
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