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Side-Effects of Anti-Inflammatory Drugs pp 377–392Cite as

Anti-inflammatory drugs and renal synthesis of prostaglandins and thromboxane in patients with systemic lupus erythematosus

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Part of the book series: Inflammation and Drug Therapy Series ((IDTH,volume 2))

Abstract

Prostaglandin (PG) I2 or prostacyclin and thrombaxane (Tx) A2 are labile oxygenated metabolites of arachidonate with contrasting effects on platelet function, vascular tone and glomerular function1,2. In humans the corresponding stable hydration products, 6-keto-PGF1α and TxB2 respectively, are synthesized by renal cortical microsomes3, represent the most abundant cyclooxygenase products of arachidonate in isolated glomeruli4 and can be measured in urine5,6.

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References

  1. Majerus, PW (1983). Arachidonate metabolism in vascular disorders. J. Clin Invest, 72, 1521

    Google Scholar 

  2. Scharschmidt, LA, Lianos, E and Dunn, MJ (1983) Arachidonate metabolites and the control of glomerular function. Fed Proc, 42 3058

    PubMed  CAS  Google Scholar 

  3. Hassid, A and Dunn, MJ (1980). Microsomal prostaglandin biosynthesis of human kidney. J Biol Chem, 255, 2472

    PubMed  CAS  Google Scholar 

  4. Sraer, J, Ardaillou, N, Sraer J-D and Ardaillou, R (1982). In vitro prostaglandin synthesis by human glomeruli and papillae. Prostaglandins, 23, 855

    Article  PubMed  CAS  Google Scholar 

  5. Ciabattoni, G, Pugliese, F, Cinotti, GA, Stirati, G, Ronci, G, Castrucci, G, Pierucci, A, and Patron, C (1979). Characterization of furosemide-induced activation of the renal prostaglandin system. Eur J Pharmacol, 60, 181

    Article  PubMed  CAS  Google Scholar 

  6. Patrono C, Pugliese, F, Ciabattoni, G et al. (1982). Evidence for a direct stimulatory effect of prostacyclin on renin release in man. J Clin Invest 69, 231

    Article  PubMed  CAS  Google Scholar 

  7. Brenner, BM, Meyer, TW and Hostetter, TH (1982). Dietary protein inteake and the progressive nature of kidney disease: the role of hemodynamically mediated glomerular injury in the pathogenesis of progressive glomerular sclerosis in aging, renal ablation, and intrinsic renal disease. N Engl J Med, 307, 652

    Article  PubMed  CAS  Google Scholar 

  8. Brenner, BM and Schor, N (1983). Studies of prostaglandin action on the glomerular microcirculation, In: Prostaglandin and the Kidney Biochemistry, Physiology, Pharmacology and Clinical Applications, ( MJ Dunn, C Patrono and GA Cinotti, eds). ( New York: Plenum ), p 125

    Google Scholar 

  9. Fitzgerald, GA, Pedersen AK and Patrono, C (1983). Analysis of prostacyclin and thromboxane biosynthesis in cardiovascular disease. Circulation, 67, 1174

    Article  PubMed  CAS  Google Scholar 

  10. Ciabattoni, G, Patrignani, P. Filabozzi, P et al. (1982). Increased renal thromboxane production in systemic lupus erythematosus. Clin Res, 30, 445A

    Google Scholar 

  11. Ciabattoni, G, Cinotti, GA, Pierucci, A et al. (1984). Effects of sulindac and ibuprofen in patients with chronic glomerular disease. N Engl J Med, 310, 279

    Article  PubMed  CAS  Google Scholar 

  12. Tan, EM, Cohen, AS, Fries, JF et al. (1982). The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum, 25, 1271

    Article  PubMed  CAS  Google Scholar 

  13. Churg, J and Sobin, LH (1982). Renal Disease (Classification and atlas of glomerular disease. ( Tokyo: Igaku-Shoin )

    Google Scholar 

  14. Ciabattoni, G, Pugliese, F, Spaldi, M, Cinotti, GA and Patrono, C (1979). Radioin¢nunoassay of prostaglandins E2 and F2a in human urine. J Endocrinol Invest, 2, 173

    PubMed  CAS  Google Scholar 

  15. Patrono, C, Ciabattoni, G, Patrignani, P et al. (1983). Evidence for a renal origin of urinary thromboxane B2 in health and disease. In: Advances in Prostaglandin, Thromboxane and Leukotriene Reasearch, ( B Samuelsson, R Paoletti, and P Ramwell, eds). ( New York: Raven Press ), p. 493

    Google Scholar 

  16. Roberts, LJ II, Sweetman, BJ, and Oates, JA (1981). Metabolism of thromboxane B2 in man: identification of twenty metabolites. J Biol Chem, 256, 8384

    PubMed  CAS  Google Scholar 

  17. Patrono, C, Ciabattoni, G, Remuzzi, G et al. (1985). The functional signficance of renal prostacyclin and thromboxane A2 in patients with systemic lupus erythematosus. J Clin Invest (In press)

    Google Scholar 

  18. Patrono, C, Ciabattoni, G, Pinca, E et al. (1980). Low dose aspirin and inhibition of thromboxane B2 production in healthy subjects. Throm Res 17, 317

    Article  CAS  Google Scholar 

  19. Patrignani, P, Filabozzi, P and Patrono, C, (1982). Selective cumulative

    Google Scholar 

  20. inhibition of platelet thromboxane production by low-dose aspirin in healthy subjects. J Clin Invest 69, 1366

    Google Scholar 

  21. Currie, M, Kawasaki, A, Jonas, P, Davis B, and Needleman, P, (1983). The mechanism and site of the enhanced arachidonate metabolism in ureter obstruction. In: Prostaglandins and the Kidney. Biochemistry, Physiology, Pharmacology, and Clinical Applications, ( MJ Dunn, C Patrono and GA Cinotti, eds) ( New York: Plenum ), p 299

    Google Scholar 

  22. Morrison, AR, Nishikawa, K, and Needleman, P, (1977). Unmasking of thromboxane A2 synthesis by ureter obstruction in the rabbit kidney. Nature, 269, 259

    Article  Google Scholar 

  23. Zipser, R, Meyers, S, and Needleman, P, (1980). Exaggerated prostaglandin and thromboxane synthesis in the rabbit with renal vein constriction, Circ.Res, 47, 231

    PubMed  CAS  Google Scholar 

  24. Benabe, JE, Klahr, S, Hoffman MK, and Morrison, AR (1980). Production of thromboxane A2 by the kidney in glycerol-induced acute renal failure in the rabbit. Prostaglandins, 19, 333

    Article  PubMed  CAS  Google Scholar 

  25. Lianos, E, Andres, GA, and Dunn, MJ (1983). Glomerular prostaglandin and thromboxane synthesis in rat nephrotoxic serum nephritis. Effects on renal hemodynamics. J Clin Invest, 72, 1439

    Google Scholar 

  26. Frblich, JC, Wilson, TW, Sweetman, BJ et al. (1975). Urinary prostaglandins. Identification and origin. J Clin Invest, 55, 763.

    Google Scholar 

  27. Marchesi, D, Parbtani, A, Frampton, G, Livio, M, Remuzzi, G and Cameron, JS (1981). Thrombotic tendency in systemic lupus erythematosus. Lancet, 1, 719

    Article  PubMed  CAS  Google Scholar 

  28. Okegawa, T, Jonas, PE, DeSchryver, K, Kawasaki, A, and Needleman, P, (1983). Metabolic and cellular alterations underlying the exaggerated renal prostaglandin and thromboxane synthesis in ureter obstruction in rabbits. Inflammatory response involving fibroblasts and mononuclear cells. J Clin Invest, 71, 81

    Google Scholar 

  29. Bombardieri, S, Cattani, P, Ciabattoni, G, Di Munno, 0, Pasero, G and Patrono, C (1981). The synovial prostaglandin system in chronic inflammatory arthritis: differential effects of steroidal and nonsteroidal anti-inflammatory drugs. Br J Pharmacol, 73, 893

    CAS  Google Scholar 

  30. Hirata, F, Del Carmine, R, Nelson, CA et al. (1981). Presence of autoantibody for phospholipase inhibitory protein, lipomodulin, in patients with rheumatic diseases. Proc Natl Acad Sci USA, 78, 3190

    Article  PubMed  CAS  Google Scholar 

  31. Kelley, VE (1985). Increased renal thromboxane production in murine lupus nephritis. Kidney Int, 27, 214

    Google Scholar 

  32. Gryglewski, RJ, Bunting, S, Moncada, S, Flower, RJ and Vane, JR (1976). Arterial walls are protected against deposition of platelet thrombi by a substance ( Prostaglandin X) which they make from prostaglandin endoperoxides. Prostaglandins, 12, 685

    Google Scholar 

  33. Stork, JE and Dunn, MJ (1984). Immune glomerulonephritis in the rat: renal function, thromboxane A2 and PGE2. Clin Res, 32, 565A

    Google Scholar 

  34. Kimberly, RP, Gill, JR, Bowden, RE, Keiser, HR and Plotz, PH (1978). Elevated urinary prostaglandins and the effects of aspirin on renal function in lupus erythematosus. Ann Intern Med, 89, 336

    PubMed  CAS  Google Scholar 

  35. Patrignani, P, Filabozzi, P, Catella, F, Pugliese, F and Patrono, C, (1984). Differential effects of dazoxiben, a selective thromboxane-synthase inhibitor, on platelet and renal prostaglandin-endoperoxide metabolism. J Pharmacol Exp Ther, 228, 472

    PubMed  CAS  Google Scholar 

  36. Patrignani, P, Catella, F, Filabozzi, P et al. (1984). Differential effects of 0KY-046, a selective thromboxane-synthase inhibitor, on platelet and renal prostaglandin endoperoxide metabolism. Clin Res, 32, 246A

    Google Scholar 

  37. Patrono, C, Patrignani, P, Catella, F et al. (1984). Resistance of renal

    Google Scholar 

  38. thromboxane synthase to inhibition by dazoxiben, OKY-046 and UK-38, 485 in man. IUPHAR 9th International Congress of Pharmacology, no. 314. (London: Macmillan (abstracts)

    Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Pharmacology, Catholic University School of Medicine, 00168, Rome, Italy

    C. Patrono & G. Ciabattoni

  2. Division of Nephrology, Department of Medicine, University of Rome, La Sapienza, 00100, Rome, Italy

    G. A. Cinotti, B. M. Simonetti & A. Pierucci

Authors
  1. C. Patrono
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  2. G. Ciabattoni
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  3. G. A. Cinotti
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  4. B. M. Simonetti
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  5. A. Pierucci
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, University of Cambridge, and Strangeways Research Laboratory, Hills Road, CB2 2QD, Cambridge, UK

    K. D. Rainsford

  2. Institute of Pharmacology, University of Verona, Verona, Italy

    G. P. Velo

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© 1987 MTP Press Limited

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Patrono, C., Ciabattoni, G., Cinotti, G.A., Simonetti, B.M., Pierucci, A. (1987). Anti-inflammatory drugs and renal synthesis of prostaglandins and thromboxane in patients with systemic lupus erythematosus. In: Rainsford, K.D., Velo, G.P. (eds) Side-Effects of Anti-Inflammatory Drugs. Inflammation and Drug Therapy Series, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-9775-8_41

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  • DOI: https://doi.org/10.1007/978-94-010-9775-8_41

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-9777-2

  • Online ISBN: 978-94-010-9775-8

  • eBook Packages: Springer Book Archive

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