Abstract
Most people tolerate aspirin and other anti-inflammatory analgesics well. In some diseases (for example, asthma or urticaria) intolerance to analgesics is high and constitutes a major clinical probleml. It presents itself as: anaphylactic shock, bronchospasm, angioedema, urticaria and various skin eruptions. These symptoms suggest an allergic background, which indeed is the case in some patients, while in others pseudoallergy develops. Pseudoallergic reactions have similar clinical manifestations, and may share a common pathogenic mechanism, but the initiating event does not appear to involve a reaction between the drug and specific antibodies or sensitized T-lymphocytes. Here the common clinical manifestations of allergic and pseudoallergic reactions to aspirin are described along with their background development, as well as prevention and therapy.
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References
Rainsford, KD (1984). Aspirin and the Salicylates. ( London: Butterworths )
Stevenson, DD and Mathison, DA (1975). Aeroallergen inhalation challenge in aspirin-intolerant patients. Allergy Clin Immunol, 55, 127
Spector, SL, Wangaard, CH and Farr, RS (1979). Aspirin and concomitant idiosyncrasies in adult asthmatic patients. Allergy Clin Immunol, 64, 500
Samter, M and Beers, RF Jnr (1968). Intolerance to aspirin: clinical studies and consideration of its pathogenesis. Ann Intern Med, 68, 975
Szczeklik, A, Gryglewski, RJ, Olszewski, E, Dembinska-Kiec, A and Czerniawska-Mysik, G (1977). Aspirin sensitive asthma: the effect of aspirin on the release of prostaglandins from nasal polyps. Pharmacol Res Commun, 9, 415
Godard, P, Chaintreuil, J, Damon, M, Coupe, M, Flandre, 0, Crastes de Paulet, A and Michel, FB (1982). Functional assessment of alveolar macrophages: comparison of cells from asthmatics and normal subjects. Allergy Clin Immunol, 70, 88
Settipane, GA (1983). Aspirin and allergic diseases: a review. Am J Med, 74, 102
Szczeklik, A (1986). Analgesics, allergy and asthma. Drugs (In press)
Szczeklik, A, Nizankowska, E and Czerniawska-Mysik, G (1985). Hydrocortisone and airflow impairment in aspirin-induced asthma. J Allergy Clin Immunol (In press)
Slepian, IK, Mathews, KP and McLean, JA (1985). Aspirin-sensitive asthma. Chest, 87, 386
Hollingsworth, HM, Downing, ET, Braman, SS, Glassroth, J, Binder, R and Center, DM (1984). Identification and characterization of neutrophil chemotactic activity in aspirin-induced asthma. Am Rev Resp Dis, 130, 373
Ortolani, C, Capsoni, F, Restuccia, M, Pastorello, E, Ribold, P, Zocchi, M and Zanussi, C (1984). Neutrophil chemotactic factor of anaphylaxis release in aspirin-induced asthma. Clin Allergy, 14, 443
Szczeklik, A, Gryglewski, RJ and Czerniawska-Mysik, G (1975). Relationship of inhibition of prostaglandin biosynthesis by analgesics to asthma attacks in aspirin-sensitive patients. Br Med J, 1, 67
Pleskow, WW, Lumry, W and Simon, R (1984). Zomepirac sodium ( Zomax) hypersensitivity in aspirin-sensitive asthmatics. Am Rev Resp Dis, 130, 1170
Szczeklik, A, Gryglewski, R, Czerniawska-Mysik, G and Nizankowska, E (1986). Aspirin sensitive asthma and arachidonic acid transformations. Proc N Engl Soc Allergy (In press)
Stevenson, DD, Pleskow, WW, Simon, RA, Mathison, DA, Lumry, WR, Schatz, M and Zeiger, R (1984). Aspirin-sensitive rhinosinusitis asthma: a double-blind cross-over study of treatment with aspirin. Allergy Clin Immunol, 73, 500
Szczeklik, A and Nizankowska, E (1983). Asthma improved by aspirin-like drugs. Br J Dis Chest, 77, 153
Doeglas, HMG (1983). Chronic urticaria: intolerance for aspirin and food additives and relationship to atopy. Br J Dermatol, 108, 108
Juhlin, L (1983). Intolerance to food and drug additives. In: de Weck, AL and Bundgaard, H (eds), Handbook of Experimental Pharmacology. ( Berlin: Springer Verlag )
Warin, RP and Smith, JP (1982). Role of tartrazine in chronic urticaria. Br Med J, 284, 1443
Szczeklik, A, Gryglewski, RJ and Czerniawska-Mysik, G (1977). Clinical patterns of hypersensitivity to nonsteroidal anti-inflammatory drugs and their pathogenesis. J Allergy Clin Immunol, 60, 276
de Weck, AL (1971). Immunological effects of aspirin anhydride, a con- taminant of commercial acetylsalicylic acid preparations. Int Arch Allergy Appl Immunol, 41, 393
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© 1987 MTP Press Limited
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Szczeklik, A. (1987). Aspirin allergy. In: Rainsford, K.D., Velo, G.P. (eds) Side-Effects of Anti-Inflammatory Drugs. Inflammation and Drug Therapy Series, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-9775-8_35
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DOI: https://doi.org/10.1007/978-94-010-9775-8_35
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-9777-2
Online ISBN: 978-94-010-9775-8
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