Skip to main content
SpringerLink
Log in
Book cover

Side-Effects of Anti-Inflammatory Drugs pp 123–132Cite as

Experimental and clinical studies on the prevention of aspirin-induced gastric damage by “cytoprotective” drugs

  • Chapter

Part of the book series: Inflammation and Drug Therapy Series ((IDTH,volume 2))

Abstract

Experimental studies initiated by Robert and co-workers1,2 have demonstrated that a number of prostaglandins (PGs) given exogenously or released endogenously by “mild irritant” in the stomach3, prevent gross mucosal lesions caused by various necrotizing substances.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Robert, A, Nezamis, JE, Lancaster, C and Hanchar, AJ (1979). Cytoprotection by prostaglandins in rats: prevention of gastric necrosis produced by alcohol, HC1, NaOH, hypertonic NaC1 and thermal therapy. Gastroenterology, 77, 433

    PubMed  CAS  Google Scholar 

  2. Robert, A (1979). Cytoprotection by prostaglandins. Gastroenterology, 77, 761

    PubMed  CAS  Google Scholar 

  3. Konturek, SJ, Brzozowski, T, Piastucki, I, Radecki, T, Dembinski, A and Dembinska-Kiec A (1982). Role of locally generated prostaglandins in adaptive gastric cytoprotection. Dig Dis Sci, 27, 967

    Article  PubMed  CAS  Google Scholar 

  4. Lacy, ER and Ito, S (1982). Microscopic analysis of ethanol damage to rat gastric mucosa after treatment with a prostaglandin. Gastroenterology, 83, 619

    PubMed  CAS  Google Scholar 

  5. Konturek, SJ, Piastucki, I, Brzozowski, T, Radecki, T, Dembinska-Kiec, A, Zmuda, A and Gryglewski, R (1981). Role of prostaglandins in the formation of aspirin-induced gastric ulcers. Gastroenterology, 80, 4

    PubMed  CAS  Google Scholar 

  6. Robert, A (1981). Prostaglandins and the gastrointestinal tract. In Johnson, LR (ed) Physiology of the Gastrointestinal Tract. ( New York: Raven Press ), 1407–34

    Google Scholar 

  7. Hollander, D, Tarnawski, A, Gergely, H and Zipser, RD (1984). Sucralfate protection against ethanol induced injury: a prostaglandin-mediated process? Scand J Gastroenterol, (Suppl. 101 ), 19

    Google Scholar 

  8. Malandrino, S, Campagnoli, G, Borsa, M, Guidoboni, R and Tonon, GC (1984). Prevention of gastric mucosal lesions in rats by tri-potassium di-citrato bismuthate. Arzheim Forsch Drug Res, 34, 30

    CAS  Google Scholar 

  9. Suwa, T, Nakazima, M, Shinozaki, A, Kyogoku, K and Mori, Y (1984). Cytoprotective effect of SU-88, an anti-ulcer agent in the rat. Jap J Pharmacol, 35, 47

    Article  PubMed  CAS  Google Scholar 

  10. Rybicka, J and Gibinski, K (1978). Methyl-prostaglandin E2 analogues for healing of gastroduodenal ulcers. Scand J Gastroenterol, 13, 155

    Article  PubMed  CAS  Google Scholar 

  11. Hollander, D (1983). A multicenter, double-blind trial of sucralfate in duodenal ulcer therapy. Scand J Gastroenterol, 18, Suppl. 83, 25

    Google Scholar 

  12. Tytgat, GN, Van Renten, N, Van Olfen, G, Dekker, W, Rutgeerts, L and De Boer, J (1982). Controlled trial comparing colloidal bismuth subcitrate tablets, cimetidine and placebo in the treatment of gastric ulceration. Scand J Gastroenterol, 17 (Suppl. 80), 31

    Google Scholar 

  13. Spenney, JG and Barton, JC (1981). 15-hydroxyprostaglandin dehydrogenase and 13reductase content of gastrointestinal organs of rabbits and rats. Prostaglandins, 21 (Suppl.), 15

    Google Scholar 

  14. Konturek, SJ, Kwiecien, N, Obtulowicz, W, Polanski, M, Kopp, B and Oleksy, J (1983). Comparison of prostaglandin E2 and ranitidine in prevention of gastric bleeding by aspirin in man. Gut, 24, 89

    Article  PubMed  CAS  Google Scholar 

  15. Hunt, JN and Franz, DR (1981). The effect of prostaglandin E2 on gastric mucosal bleeding caused by aspirin. Dig Dis Sci, 26, 301

    Article  PubMed  CAS  Google Scholar 

  16. Croft, DN and Lubrant, M (1965). The estimation of deoxyribonucleic acid in the presence of sialic acid application to analysis of human gastric washings. Biochem J, 95, 612

    PubMed  CAS  Google Scholar 

  17. Nagashima, R (1981). Mechanisms of action of sucralfate. J Clin Gastroenterol, 3 (Suppl. 2), 117

    PubMed  CAS  Google Scholar 

  18. Wieriks, J, Hespe, W, Jaitly, KD, Koeppock, PH and Lavy, V (1980). Pharmacological properties of colloidal bismuth subcitrate CBS, De-Nol. Scand J Gastroenterol, ( Suppl. 80 ), 11–16

    Google Scholar 

  19. Matsuo, Y, Seki, A, Yakabi, K, Sazaki, R, Arai, I, Isobe, Y and Aihara, H (1983). Effects of 2-carboxymethoxy-4, 4-bis (3-methyl-2-butenyloxy) chalone (SU-88) on gastric local blood flow. Arzneimittelforsch, 33, 242

    CAS  Google Scholar 

  20. Suwa, T, Fukushima, K and Kyogoku, K (1984). Effects of an anti-ulcer agent, 2-carboxymethoxy,4,4-bis (3-methyl-2-butenyloxy) chalone (SU-88) on the biosynthesis of gastric sulfated mucosubstances in restained and water-immersed rats. Jap J Pharmacol, 34, 89

    Article  PubMed  CAS  Google Scholar 

  21. Slomiany, BL, Murty, VLN, Laszewicz, W, Piasek, A and Slomiany, H (1985). Effect of sucralfate on the viscosity and retardation of hydrogen ion diffusion by gastric mucus. Gastroenterology, 88, 1591

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Physiology, Academy of Medicine, 31-531, ul. Grzegórzecka 16, Kraków, Poland

    S. J. Konturek, N. Kwiecien, T. Radecki & J. Oleksy

Authors
  1. S. J. Konturek
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. N. Kwiecien
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. T. Radecki
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J. Oleksy
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Pharmacology, University of Cambridge, and Strangeways Research Laboratory, Hills Road, CB2 2QD, Cambridge, UK

    K. D. Rainsford

  2. Institute of Pharmacology, University of Verona, Verona, Italy

    G. P. Velo

Rights and permissions

Reprints and permissions

Copyright information

© 1987 MTP Press Limited

About this chapter

Cite this chapter

Konturek, S.J., Kwiecien, N., Radecki, T., Oleksy, J. (1987). Experimental and clinical studies on the prevention of aspirin-induced gastric damage by “cytoprotective” drugs. In: Rainsford, K.D., Velo, G.P. (eds) Side-Effects of Anti-Inflammatory Drugs. Inflammation and Drug Therapy Series, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-9775-8_11

Download citation

  • DOI: https://doi.org/10.1007/978-94-010-9775-8_11

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-9777-2

  • Online ISBN: 978-94-010-9775-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation