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Mechanisms of gastric contrasted with intestinal damage by non-steroidal anti-inflammatory drugs

  • Chapter
Side-Effects of Anti-Inflammatory Drugs

Part of the book series: Inflammation and Drug Therapy Series ((IDTH,volume 2))

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) differ in the propensity to cause irritation, ulceration and haemorrhage in the various regions of the gastro intestinal (GI) tract. Some drugs such as aspirin and other salicylates cause damage principally in the stomach and duodenum1, 2. However, there is now increasing evidence from clinical reports in man that some other NSAIDs may, in addition to causing damage in these upper GI regions2, also cause ulceration and haemorrhage in the lower regions of the small intestine, caecum and colon3–6 (Table 1). In fact the problem was of such concern in the case of the osmotic slow-release formulation of indomethacin (Osmosin) and for indoprofen* (Flosint) as to necessitate their withdrawal recently. There has also been concern that some NSAIDs with potent actions as inhibitors of prostaglandin (PG) synthesis might exacerbate inflammatory bowel diseases (IBDs)5.

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  1. Department of Pharmacology, University of Cambridge, Hills Road, Cambridge, CB2 2QD, UK

    K. D. Rainsford

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  1. Department of Pharmacology, University of Cambridge, and Strangeways Research Laboratory, Hills Road, CB2 2QD, Cambridge, UK

    K. D. Rainsford

  2. Institute of Pharmacology, University of Verona, Verona, Italy

    G. P. Velo

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Rainsford, K.D. (1987). Mechanisms of gastric contrasted with intestinal damage by non-steroidal anti-inflammatory drugs. In: Rainsford, K.D., Velo, G.P. (eds) Side-Effects of Anti-Inflammatory Drugs. Inflammation and Drug Therapy Series, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-9775-8_1

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