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Neutrophil interactions with particulate materials: an in vitro model for inflammatory arthritides

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Inflammation: Mechanisms and Treatment

Part of the book series: Inflammation: Mechanisms and Treatment ((FTIN,volume 4))

Abstract

Previous studies by our group1 and others2 have established in vitro systems for examining the interactions between neutrophils and immunoglobulin G aggregates or monosodium urate crystals which may be important in the inflammatory processses occurring in rheumatoid arthritis and gout. The present studies utilize a previously described3 neutrophil monolayer system to quantitate the uptake of these particulate materials along with their subsequent effects on cellular adherence and enzyme release.

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References

  1. Turner, R., Collins, R., Browner, S., et al. (1976). Neutrophil and rheumatoid factor-immunoglobulin G insoluble complex interactions: phagocytosis and sequelae. J. Rheumatol., 3, 109

    PubMed  CAS  Google Scholar 

  2. Weissmann, G., Zurier, R., Spieler, T. and Goldstein, I. (1971). Mechanisms of lysosomal enzyme release from leukocytes exposed to immune complexes and other particles. J. Exp. Med., 134, 149s

    PubMed  CAS  Google Scholar 

  3. Turner, R., Counts, G., Mashburn, H., Treadway, W., and DeChatelet, L. (1980). Drug and rheumatoid factor effects on the uptake of immunoglubulin G aggregates by neutrophil monolayers. Inflammation (In press)

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  4. Lowry, O. H., Rosebrough, N. J., Farr, A. L. and Randall, R. (1951). Protein measurement with the Folin phenol reagent. J. Biol. Chem., 193, 265

    PubMed  CAS  Google Scholar 

  5. Seegmiller, J. E., Howell, R. R. and Malawista, S. E. (1962). The inflammatory reaction to sodium urate. Its possible relationship to the genesis of gouty arthritis. J. Am. Med. Assoc., 180, 469

    Article  CAS  Google Scholar 

  6. Turner, R., Martin, M., Schroff, J., Treadway, W. and DeChatelet, L. (1979). Neutrophil enzyme activities in rheumatoid inflammation. Inflammation, 3, 219

    Article  Google Scholar 

  7. Turner, R., Mashburn, H., Collins, R. et al. (1977). Rheumatoid factor immunoglobulin G complex precipitation and neutrophil stimulation: an in vitro model for rheumatoid inflammation. In Willoughby, D. A. (ed.) Perspectives in Inflammation-Future Trends and Developments, pp.39–46. (Lancaster: MTP Press)

    Google Scholar 

  8. Shumacher, H., Fishbein, P., Phelps, R. et al. (1975). Comparison of sodium urate and calcium pyrophosphate crystal phagocytosis by polymorphonuclear leukocytes. Arthritis Rheum., 18, 783s

    Article  Google Scholar 

  9. Treadway, W., Collins, R. L., Turner, R. A. and DeChatelet, L. (1979). Polymorphonuclear leukocyte secretory and metabolic responses to immunoglobulin aggregates. J. Rheumatol., 6, 636

    PubMed  CAS  Google Scholar 

  10. Kosen, F., Kinsburg, M. and Skosey, J. (1979). Polymorphonuclear leukocyte responses to monosodium urate crystals: modification by absorbed serum proteins. J. Rheumatol., 6, 519

    Google Scholar 

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© 1980 MTP Press Limited

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Turner, R., Counts, G., Johnson, J., West, E., Treadway, W. (1980). Neutrophil interactions with particulate materials: an in vitro model for inflammatory arthritides. In: Willoughby, D.A., Giroud, J.P. (eds) Inflammation: Mechanisms and Treatment. Inflammation: Mechanisms and Treatment, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-9423-8_51

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  • DOI: https://doi.org/10.1007/978-94-010-9423-8_51

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-9425-2

  • Online ISBN: 978-94-010-9423-8

  • eBook Packages: Springer Book Archive

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