Abstract
Rheumatoid synovium has proliferative and destructive characteristics in vivo. These capabilities are also evident in tissue culture studies in which cultured expiants of rheumatoid synovium have been shown to invade normal tendon1 and release substances which stimulate bone resorption2. There are numerous biochemical differences between normal and inflamed synovia but it is likely that the destructive capacity of rheumatoid tissues is related in part to formation of high levels of prostaglandins (PGs) and collagenase3,4. PGE2, released from cultured rheumatoid synovium, stimulates bone resorption2 and collagenase is believed to be the major enzyme responsible for cartilage degradation associated with rheumatoid arthritis5,6.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Harris, E. D., Jr., DiBona, D. R. and Krane, S. M. (1970). A mechanism for cartilage destruction in rheumatoid arthritis. Trans. Assoc. Am: Physicians, 83, 267
Robinson, D. R., Tashjian, A. H. Jr. and Levine, L. (1975). Prostaglandin-stimulated bone resorption by rheumatoid synovia. J. Clin. Invest., 56, 1181
Robinson, D. R. and McGuire, M. B. (1975). Prostaglandins in the rheumatic diseases. Ann. N. Y. Acad Sci., 256, 318
Evanson, J.M., Jeffrey, J. J. and Krane, S. M. (1967). Human collagenase: identification and characterisation of an enzyme from rheumatoid synovium in culture. Science, 158, 499
Harris, E. D., Jr. and Krane, S. M. (1974). Collagenases. TV. Engl. J. Med., 291, 557,
Harris, E. D., Jr. and Krane, S. M. (1974). Collagenases. TV. Engl. J. Med., 291, 605,
Harris, E. D., Jr. and Krane, S. M. (1974). Collagenases. TV. Engl. J. Med., 291, 652
Woolley, D. E. and Evanson, J. M. (1977). Collagenase and its natural inhibitors in relation to the rheumatoid joint. Connective Tissue Res., 5, 31
Dayer, J.-M., Krane, S. M., Russell, R. G. G. and Robinson, D. R. (1976). Production of collagenase and prostaglandins by isolated adherent rheumatoid synovial cells. Proc. Natl. Acad. Sci. (USA), 73, 945
Wahl, L. M., Olsen, C. E., Sandberg, A. L. and Mergenhagen, S. E. (1977). ‘Prostaglandin regulation of macrophage collagenase production’. Proc. Natl. Acad. Sci. (USA)., 74, 4955
Brinckerhoff, C. E., McMillan, R. M., Fahey, J. V. and Harris, E. D., Jr. (1979). Collagenase production by synovial fibroblasts treated with phorbol myristic acetate. Arthritis Rheum., 22, 1109
Brinckerhoff, C. E. and Harris, E. D. Jr. (1978). Collagenase production by cultures containing multinucleate giant cells derived from synovial fibroblasts. Arthritis Rheum., 21, 745
Harris, E. D. Jr., Reynolds, J. J. and Werb, Z. (1975). Cytochalasin B increases collagenase production by cells in vitro. Nature (London). 257, 243
Harris, E. D. Jr., DiBona, D. R. and Krane, S. M. (1969). Collagenase in human synovial fluid. J. Clin. Invest., 48, 2104
Lowry, O. H., Rosebrough, N. J., Farr, A. L. and Randall, R. J. (1951). Protein measurement with the folin reagent. J. Biol. Chem., 193, 265
Dray, F., Charbonnel, B. and MacLouf, J. (1975). Radioimmunoassay for prostaglandins F, E1 and E2 in human plasma. Eur. J. Clin. Invest., 5, 311
McMillan, R. M., Brinckerhoff, C. E. and Harris, E. D. Jr. (1980). Specificity of glucocorticoid inhibition of synovial prostaglandin synthesis. (This volume ch. 44)
Dayer, J.-M., Robinson, D.R. and Krane, S. M. (1977). Prostaglandin production by rheumatoid synovial cells. Stimulation by a factor from human mononuclear cells J. Exp. Med., 145, 1399
Dayer, J.-M. and Krane, S. M. (1978). Interaction of immunocompetent cells and chronic inflammation as exemplified by rheumatoid arthritis. Clin. Rheum. Dis., 4, 517
Dayer, J.-M., Goldring, S.R. and Krane, S.M. (1978). Connective tissue resorption and rheumatoid arthritis: synovial cell culture as a model. Horton, Tarplay and Davis (eds) Proceedings, Mechanisms of Localized Bone Loss. Special supplement to Calcified Tissue Abstracts, p. 305.
Werb, Z., Mainardi, C. L., Vater, C. A. and Harris, E. D. Jr. (1977). ‘Endogenous activation of latent collagenase by rheumatoid synovial cells. Evidence for a role of plasminogen activator. N. Engl. J. Med., 296, 1017
Woolley, D. E., Harris, E. D. Jr., Mainardi, C. L. and Brinckerhoff, C. E. (1978). Collagenase immunolocalization in cultures of rheumatoid synovial cells. Science, 200, 773
Woolley, D.E., Brinckerhoff, C. E., Mainnardi, C. L., Vater, C.A., Evanson, J. M. and Harris, E. D., Jr. (1979). Collagenase production by rheumatoid synovial cells: morphological and immunohistochemical studies of the dendritic cell, Ann. Rheum. Dis. 38, 262
McMillan, R. M., Fahey, J. V., Brinckerhoff, C. E. and Harris, E. D., Jr. (1980). Secretion of inflammatory mediators from synovial fibroblasts: dissociation of collagenase and prostaglandin release. In Samuelsson, B., Ramwell, P.W. and Paoletti, R. (eds.) Advances in Prostaglandin and Thromboxane Research. Vol. 8, p. 1701. (New York: Raven Press)
McMillan, R. M., Brinckerhoff, C. E. and Harris, E. D. (unpublished data)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1980 MTP Press Limited
About this chapter
Cite this chapter
McMillan, R.M., Brinckerhoff, C.E., Harris, E.D. (1980). Collagenase release from synovial fibroblasts: relationship to fatty acid release and prostaglandin synthesis. In: Willoughby, D.A., Giroud, J.P. (eds) Inflammation: Mechanisms and Treatment. Inflammation: Mechanisms and Treatment, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-9423-8_45
Download citation
DOI: https://doi.org/10.1007/978-94-010-9423-8_45
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-9425-2
Online ISBN: 978-94-010-9423-8
eBook Packages: Springer Book Archive