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Inflammation: Mechanisms and Treatment pp 267–283Cite as

Selective control of formation of 1 and 2 series prostaglandins: a new concept in the regulation of inflammation and immunity

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Part of the book series: Inflammation: Mechanisms and Treatment ((FTIN,volume 4))

Abstract

The roles of prostaglandins (PGs) and thromboxanes (TXs) in inflammation are uncertain. There can be no doubt that these agents are formed in increased amounts in a wide variety of inflammatory conditions and that inhibition of that formation by steroids and by non-steroidal anti-inflammatory drugs (NSAID) is well correlated with relief of symptoms in both acute and chronic inflammatory conditions in humans and with suppression of some of the features of acute inflammation in animal models. On the other hand, there is equally no doubt that glucocorticoids and NSAID do not favourably influence the long-term course of most chronic inflammatory states in humans1. Furthermore there is a good deal of evidence that PGs can play antiinflammatory roles2–5.

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Authors and Affiliations

  1. Canada

    D. F. Horrobin, M. S. Manku, M. Oka & S. C. Cunnane

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  1. D. F. Horrobin
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  2. M. S. Manku
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  3. M. Oka
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  4. S. C. Cunnane
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Editors and Affiliations

  1. Department of Experimental Pathology and Rheumatology, St Bartholomew’s Hospital, London, UK

    D. A. Willoughby (Professor) (Professor)

  2. Department of Pharmacology, Hôpital Cochin, Paris, France

    J. P. Giroud (Professor) (Professor)

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Horrobin, D.F., Manku, M.S., Oka, M., Cunnane, S.C. (1980). Selective control of formation of 1 and 2 series prostaglandins: a new concept in the regulation of inflammation and immunity. In: Willoughby, D.A., Giroud, J.P. (eds) Inflammation: Mechanisms and Treatment. Inflammation: Mechanisms and Treatment, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-9423-8_40

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  • DOI: https://doi.org/10.1007/978-94-010-9423-8_40

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