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Inhibitory effect of benoxaprofen and BW 755C on rabbit PMN leukocyte lipoxygenase (Abstract)

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Part of the Inflammation: Mechanisms and Treatment book series (FTIN,volume 4)

Abstract

Arachidonic acid is metabolized by rabbit peritoneal PMNs via both prostaglandin cyclo-oxygenase and fatty acid lipoxygenase pathways to yield a multiplicity of biologically active products. These activities have been well characterized for the prostaglandins and thromboxanes and recent attention has been directed to the activities of the many hydroxy substituted arachidonic acid metabolites including leukocyte chemotactic and chemokinetic stimulation and possible mediation of leukoctye aggregation1,2.

Keywords

  • Arachidonic Acid
  • Active Product
  • Treatment Mation
  • Acid Metabolite
  • Calcium Ionophore

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References

  1. Goetzl, E. J. and Sun, F. F. (1979). J. Exp. Med. 150, 406

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  2. Ford-Hutchinson, A. W., Bray, M. A. and Smith, M. J. H. (1979). J. Pharm. Pharmacol, 31, 868

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  3. Higgs, G., Flower, R.J. and Vane, J. R. (1979). Biochem. Pharmacol., 28, 1959

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  4. Walker, J. R. and Dawson, W. (1979). J. Pharm. Pharmacol., 31, 778

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© 1980 MTP Press Limited

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Walker, J.R., Dawson, W. (1980). Inhibitory effect of benoxaprofen and BW 755C on rabbit PMN leukocyte lipoxygenase (Abstract). In: Willoughby, D.A., Giroud, J.P. (eds) Inflammation: Mechanisms and Treatment. Inflammation: Mechanisms and Treatment, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-9423-8_38

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  • DOI: https://doi.org/10.1007/978-94-010-9423-8_38

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-9425-2

  • Online ISBN: 978-94-010-9423-8

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