Skip to main content

Mycoplasmas stimulate mouse peritoneal macrophages to secrete lysosomal enzymes and to be cytotoxic

  • Chapter
Inflammation: Mechanisms and Treatment

Part of the book series: Inflammation: Mechanisms and Treatment ((FTIN,volume 4))

Abstract

The pathogenic mechanisms in mycoplasma infections are not fully understood. Several mechanisms may contribute to the recovery of animals from mycoplasma infections and resistance to reinfections. A feature of mycoplasma infections in the lungs and other sites is the associated mononuclear cell reaction. The infiltrating cells belong mainly to the lymphocyte and macrophage series. In bronchiolar exudates of mice infected with M.pulmonis 1,2 and hamsters infected with M.pneumoniae, macrophages are common. Serum antibodies transferred from mice recovering from pneumonia to recipient mice provides some protection against the development of pneumonia in these animals following inoculation of M.pulmonis 3. According to the well-known view of Mackaness4, immunity to infectious bacteria has two components.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Lindsey, J. R. and Cassell, G. (1973). Experimental mycoplasma pulmonis infection in pathogen-free mice: models for studying mycoplasmosis of the respiratory tract. Am. J. Pathol., 72, 63

    PubMed  CAS  Google Scholar 

  2. Taylor, G. and Taylor-Robinson, D. (1975). The part played by cell mediated immunity in mycoplasma respiratory infections. Dev. Biol. Stand., 28, 195

    PubMed  CAS  Google Scholar 

  3. Taylor, G. and Taylor-Robinson, D. (1977). Factors involved in resistance to and recovery from mycoplasma pulmonis induced arthritis in mice. Ann. Rheum. Dis., 36, 232

    Article  PubMed  CAS  Google Scholar 

  4. Mackaness, G. B. (1962). Cellular resistance to infection. J. Exp. Med., 116, 381

    Article  PubMed  CAS  Google Scholar 

  5. Ward, P. A., Renold, H.G. and David, J. R. (1970). The production by antigen stimulated lymphocytes of a leukotactic factor distinct from migration inhibitory factor. Cell. Immunol., 1,162

    Article  PubMed  CAS  Google Scholar 

  6. Showell, H. S., Tear, R. J., Zigmond, S. H., Schiffman, G., Aswanikumar, S. Corcoran, B. and Becker, G. L. (1976). The structure-activity relations of synthetic peptides as chemotac-tic factors and inducers of lysosomal enzyme secretion for neutrophils. J. Exp. Med., 143, 1154

    Article  PubMed  CAS  Google Scholar 

  7. Schoriemmer, H. U., Davies, P. and Allison, A. C. (1976). Ability of activated complement components to induce lysosomal enzyme release from macrophages. Nature (London), 261, 48

    Article  Google Scholar 

  8. Ferluga, J., Schoriemmer, H. U., Baptisda, L. and Allison, A. C. (1976). Cytolytic effects of the complement cleavage product C3a. Br. J. Cancer, 34, 626

    Article  PubMed  CAS  Google Scholar 

  9. Schoriemmer, H. U., Ferluga, J. and Allison, A. C. (1977). Interactions of macrophages and complement components in the pathogenesis of chronic inflammation. In Wil-loughby, D. A., Giroud, J. P. and Velo, G. P. (eds.) Perspectives in Inflammation, p. 191. (Lancaster: MTP Press)

    Google Scholar 

  10. Taylor-Robinson, D., Schoriemmer, H. U., Furr, P. M. and Allison, A. C. (1978). Macrophage secretion and the complement cleavage product C3a in the pathogenesis of infections by mycoplasmas and L-forms of bacteria and immunity to these organisms. Clin. Exp. Immunol., 33, 486

    PubMed  CAS  Google Scholar 

  11. Schoriemmer, H. U., Bitter-Suermann, D. and Allison, A.C. (1977) Complement activation by the alternative pathway and macrophage enzyme secretion in the pathogenesis of chronic inflammation. Immunology., 32, 929

    Google Scholar 

  12. Mackaness, G. B. (1971). Resistance to intracellular infection. J. Infect. Dis., 123, 439

    Article  PubMed  CAS  Google Scholar 

  13. Lai A Fat, R. F. M. and van Fürth, F. (1975). In vitro synthesis of some complement components (Clq, C3 and C4) by lymphoid tissues and circulating leucocytes in man. Immunology., 28, 359

    PubMed  Google Scholar 

  14. Bentley, C., Bitter-Suermann, D., Hadding, U. and Brade, V. (1976). In vitro synthesis of factor B of the alternative pathway of complement activation by mouse peritoneal macrophages. Eur. J. Immunol., 6, 393

    Article  PubMed  CAS  Google Scholar 

  15. Schoriemmer, H. U., Hadding, U. and Bitter-Suemann, D. (1979). Effects of complement cleavage products released from stimulated macrophages in allergic diseases. Eur. J. Rheum. Inflam., 2, 130

    Google Scholar 

  16. Bredt, W. (1975). Phagocytosis by macrophages of mycoplasma pneumoniae after opsonization by complement. Infect. Immun., 12, 695

    Google Scholar 

  17. Bredt, W. and Bitter-Suermann, D. (1975). Interactions between mycoplasma pneumoniae and guinea pig complement. Infect. Immun., 11, 497

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1980 MTP Press Limited

About this chapter

Cite this chapter

Schorlemmer, H.U., Kist, M., Bredit, W. (1980). Mycoplasmas stimulate mouse peritoneal macrophages to secrete lysosomal enzymes and to be cytotoxic. In: Willoughby, D.A., Giroud, J.P. (eds) Inflammation: Mechanisms and Treatment. Inflammation: Mechanisms and Treatment, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-9423-8_117

Download citation

  • DOI: https://doi.org/10.1007/978-94-010-9423-8_117

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-9425-2

  • Online ISBN: 978-94-010-9423-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics