Summary
Available evidence suggests that milk fat globules originate from endoplasmic reticulum of mammary epithelial cells. The actual process by which these globules are formed is unknown, but there are indications that triglyceride-containing vesicles which bleb from endoplasmic reticulum may serve as nucleation sites for globules. After formation, lipid droplets grow within the cell and this growth appears to be mediated by fusion of triglyceride-containing vesicles with intracellular lipid droplets. After formation, lipid droplets migrate to apical regions of cells, from where they are secreted into the alveolar lumen. Some evidence that microtubules and microfilaments may be involved in the intracellular migration of lipid droplets has been obtained, but this evidence is equivocal. Lipid droplets are released from the cell by envelopment in specialized regions of apical plasma membrane. Membranes of secretory vesicles may also make a contribution to the membrane which envelops lipid droplets. As reviewed herein, the membrane which surrounds fat globules in milk has been extensively characterized.
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Keenan, T.W., Dylewski, D.P., Woodford, T.A., Ford, R.H. (1983). Origin of Milk Fat Globules and the Nature of the Milk Fat Globule Membrane. In: Fox, P.F. (eds) Developments in Dairy Chemistry—2. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-9231-9_3
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