Abstract
Several hyothesis have associated the maternal-age related rise in aneuploidie in mammals with events taking place during different stages of oocyte development (for reviews see: Bond and Chandley, 1983; Hassold and Jacobs, 1984). For instance, the production line hypothesis proposes that a decrease in cross-over activity during early stages in meiosis in those oocytes in the embryo determined to become ovulated late in life increases the number of univalents. This is supposed to influence the equal distribution of chromosomes. Other theories relate induction of aneuploidy to damage of the oocyte due to environmental hazzards during its long resting and growth in the ovary before ovulation. Hormonal imbalance in organisms approaching the end of their reproductive lifespan is also thought to participate in aetiology of aneuploidy. It seems to affect mainly maturation.
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References
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© 1987 The Organising Committee of the Ninth International Chromosome Conference, Marseille
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Eichenlaub-Ritter, U. (1987). The oocyte spindle and predisposition to aneuploidy in mice. In: Stahl, A., Luciani, J.M., Vagner-Capodano, A.M. (eds) Chromosomes Today. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-9166-4_22
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DOI: https://doi.org/10.1007/978-94-010-9166-4_22
Publisher Name: Springer, Dordrecht
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