Abstract
The transfer of foreign DNA into mammalian cells was first described by Szybalska and Szybalski (1962). Subsequent research by many investigators resulted in the development of selection systems for identification of DNA transformed cells. The discovery of covalent linkage between chromosomal DNA and DNA introduced by DNA-mediated transfer led to new approaches for gene mapping and studies of gene regulation in mammalian cells (reviewed in Pellicer et al., 1981). Theoretically, any type of DNA can be stably incorporated into chromosomes, including viral, prokaryotic and non-self (or self) eukaryotic DNA.
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© 1987 The Organising Committee of the Ninth International Chromosome Conference, Marseille
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Henderson, A.S. (1987). Chromosome accommodation to integration of foreign DNA. In: Stahl, A., Luciani, J.M., Vagner-Capodano, A.M. (eds) Chromosomes Today. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-9166-4_2
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DOI: https://doi.org/10.1007/978-94-010-9166-4_2
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