Abstract
Considering that the human aneuploid conditions were first identified more than twenty years ago, it is remarkable that our understanding of the mechanisms involved remains so inadequate. Probably no other aspect of human aneuploidy has attracted more attention over the years than the aetiology, and yet the cause of Down’s syndrome still eludes us and the factors underlying the maternal age effect remain obscure.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Baker, T.G., Challoner, S. and Burgoyne, P.S. 1980. The number of oocytes and the rate of atresia in unilaterally ovariectomized mice up to 8 months after surgery. J. Reprod. Fert. 60: 449–456
Brook, J.D. 1983. Non-disjunction in mammalian germ cells. PhD thesis. University of Edinburgh.
Brook, J.D., Gosden, R.G. and Chandley, A.C. (in press). Maternal ageing and aneuploid embryos - Evidence from the mouse that biological and not chronological age is the important influence. Hum. Genet.
Henderson, S.A. and Edwards, R.G. 1968. Chiasma frequency and maternal age in mammals. Nature 218: 22–28.
Jagiello, G. and Fang, J.S. 1979. Analysis of diplotene chiasma frequencies in mouse oocytes and spermatocytes in relationship to ageing and sexual dimorphism. Cytogenet. Cell Genet. 23: 53–60.
Polani, P.E., Briggs, J.H., Ford, C.E., Clark, C.M., and Berg, J.M. 1960. A mongol girl with 46 chromosomes. Lancet i: 721–724.
Speed, R.M. and Chandley, A.C. 1983. Meiosis in the foetal mouse ovary. II. Oocyte development and age-related aneuploidy. Does a production line exist? Chromosoma (in press).
Thung, P.J. 1961. Ageing changes in the ovary. In “Structural aspects of ageing”. (Ed. G.H. Bourne ). pp. 109–142. Pitman Medical, London.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1984 The Organising Committee of the VIII International Chromosome, Conference, Lübeck
About this chapter
Cite this chapter
Chandley, A.C. (1984). Age-related aneuploidy and its aetiology — testing some of the hypotheses. In: Bennett, M.D., Gropp, A., Wolf, U. (eds) Chromosomes Today. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-9163-3_12
Download citation
DOI: https://doi.org/10.1007/978-94-010-9163-3_12
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-9165-7
Online ISBN: 978-94-010-9163-3
eBook Packages: Springer Book Archive