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Inducible enzymes with special reference to COX-2 in inflammation and apoptosis

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Improved Non-Steroid Anti-Inflammatory Drugs: COX-2 Enzyme Inhibitors

Abstract

Inflammation is a dynamic process of plasma-derived and cellular events occurring in response to tissue injury or infection. The early stages of acute inflammation are characterized by the sequential release of mediators including histamine, 5-hydroxytryptamine (5-HT), kinins, prostanoids, substance P and nitric oxide (NO). Prostaglandins (PGs) and thromboxanes (TXs), collectively termed prostanoids, are biologically active molecules operative in both acute and chronic inflammation. They are formed from membrane-released arachidonic acid by a series of enzymes including cyclooxygenase (COX), alternatively named prostaglandin H synthase (PGHS), or prostaglandin endoperoxidase synthase.

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Authors
  1. D. A. Willoughby
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  2. A. Tomlinson
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  3. D. Gilroy
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  4. D. Willis
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Editors and Affiliations

  1. The William Harvey Research Institute, Saint Bartholomew’s Hospital Medical College, London, UK

    John Vane , Jack Botting  & Regina Botting ,  & 

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© 1996 Kluwer Academic Publishers and William Harvey Press

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Willoughby, D.A., Tomlinson, A., Gilroy, D., Willis, D. (1996). Inducible enzymes with special reference to COX-2 in inflammation and apoptosis. In: Vane, J., Botting, J., Botting, R. (eds) Improved Non-Steroid Anti-Inflammatory Drugs: COX-2 Enzyme Inhibitors. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-9029-2_4

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  • DOI: https://doi.org/10.1007/978-94-010-9029-2_4

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-9031-5

  • Online ISBN: 978-94-010-9029-2

  • eBook Packages: Springer Book Archive

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