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COX-2 expression in labour

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Improved Non-Steroid Anti-Inflammatory Drugs: COX-2 Enzyme Inhibitors

Abstract

The biochemical mechanisms of the initiation of human labour are not yet understood. Much of the work in this field has been done in animals, but there are fundamental differences in placentation, the anatomy of pregnancy and the ways in which parturition is controlled. Thus it is not always possible to draw parallel conclusions between these animals and man.

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References

  1. Challis JRG, Brookes AN. Maturation and activation of hypothalamic—pituitary function in fetal sheep. Endocr Rev. 1989; 10: 182–204.

    Article  PubMed  CAS  Google Scholar 

  2. Tangelakis K, Coghlan JP, Connell J. Tissue distribution and levels of gene expression of three steroid hydroxylases in ovine fetal adrenal gland. Acta Endocrinol. 1989; 120: 225–32.

    Google Scholar 

  3. Mason JL, France JT, Magness RR, Murrey BA, Rosenfeld CR. Ovine placental steroidogenesis in dexamethasone induced and normal parturition. J Endocrinol. 1989; 122: 351.

    Article  PubMed  CAS  Google Scholar 

  4. Jenkin G, Thorbum GD. Inhibition of progesterone secretion by a hydroxy–dehydrogenase inhibitor in late pregnancy sheep. Can J Physiol Pharmacol. 1985; 63: 136–41.

    Article  PubMed  CAS  Google Scholar 

  5. Bennett PR, Elder MG. Extreme prematurity; the aetiology of preterm delivery. Br Med Bull. 1988; 44: 850–60.

    PubMed  CAS  Google Scholar 

  6. Mitchell MD, Bibby J, Hicks BR, Redan CWG, Anderson ABM, Turnbull AC. Thromboxane B and human parturition. Concentrations in the plasma and production in vitro. J Endocrinol. 1978;78:435–41.

    Google Scholar 

  7. Sellers S, Mitchell MD, Bibby J, Anderson ABM, Tumbull AC. Comparison of plasma concentrations of prostaglandin levels in term and preterm labour. Br J Obstet Gynaecol. 1981; 88: 362–66.

    Article  PubMed  CAS  Google Scholar 

  8. Fuchs AR, Fuchs F, Husslien P, Soloff MF, Fernstrom MJ. Oxytocin receptors and human parturition. Science. 1982; 215: 1396–8.

    Article  PubMed  CAS  Google Scholar 

  9. Keirse MJNC, Flint AP, Turnbull AC. F prostaglandin in amniotic fluid during late pregnancy and labour. J Obstet Gynecol Br Commun. 1974; 81: 131–5.

    Article  CAS  Google Scholar 

  10. Keirse MJNC, Hicks BR, Mitchell MD, Tumbull AC. Increase in prostaglandin precursor arachidonic acid in amniotic fluid during spontaneous labour. Br J Obstet Gynaecol. 1977; 84: 937–40.

    Article  PubMed  CAS  Google Scholar 

  11. Macdonald PC, Schultz FM, Duenhoelter JH. Mechanism of action of arachidonic acid. Obstet Gynecol. 1974; 44: 629–36.

    PubMed  CAS  Google Scholar 

  12. Granstrom E. On the metabolism of prostaglandin F in female subjects. Eur J Biochem. 1972; 27: 462–9.

    Article  PubMed  CAS  Google Scholar 

  13. Gordon-Wright AP, Elder MG. Effects of prostaglandin EZ and F2,, metabolites on lower segment myometrium in vitro. Eur J Obstet Gynecol Reprod Biol. 1992; 10: 297–302.

    Article  Google Scholar 

  14. Karim SMM, Hillier K. The role of prostaglandins in myometrial contractions. In Josimovitch JB, ed. Uterine contractions–a side effect of steroidal contraceptives. Wiley Publications; 1973.

    Google Scholar 

  15. Bygdeman M, Bremme K, Gillespie A, Lundström V. Effects of the prostaglandins on the uterus. Acta Obstet Gynecol Scand (Suppl.) 1979; 87: 33.

    Article  CAS  Google Scholar 

  16. Turnbull AC. The fetus and birth. London: Elsevier; 1977.

    Google Scholar 

  17. Sellers S, Mitchell MD, Bibby J, Anderson ABM, Tumbull AC. Prostaglandin serum levels following vaginal examination of artificial rupture of membranes. Br J Obstet Gynaecol. 1980; 87: 43–6.

    Article  PubMed  CAS  Google Scholar 

  18. Bennett PR, Rose M, Myatt L, Elder MG. Preterm labor; Stimulation of arachidonic acid metabolism in human amnion cells by bacterial products. Am J Obstet Gynecol. 1987; 156: 649–55.

    PubMed  CAS  Google Scholar 

  19. Bennett PR, Slater D, Moore GE. Expression of a common cellular phospholipase A2 by human intrauterine tissues. Prostaglandins. 1993; 45: 121–7.

    Article  PubMed  CAS  Google Scholar 

  20. Rose MP, Elder MG, Myatt L. Arachidonic acid metabolism in the human placenta. Troph Res. 1987; 2: 71–83.

    Google Scholar 

  21. Skinner KA, Challis JRG. Changes in synthesis and metabolism of prostaglandins by human fetal membranes and decidua at labor. Am J Obstet Gynecol. 1985; 151: 519–23.

    PubMed  CAS  Google Scholar 

  22. Saeed SA, Strickland DM, Young DC, Dang A, Mitchell MD. Inhibition of prostaglandin synthesis by human amniotic fluid: Acute reduction in labor. J Clin Endocrinol Metab. 1982; 55: 801–3.

    Article  PubMed  CAS  Google Scholar 

  23. Strickland DM, Saeed SA, Casey ML, Mitchell MD. Stimulation of prostaglandin synthesis by urine of human fetus may serve as a trigger for human parturition. Science. 1983; 220: 521–2.

    Article  PubMed  CAS  Google Scholar 

  24. Hoffman DR, Romero R, Johnston JM. Detection of platelet activating factor in amniotic fluid of complicated pregnancies. Am J Obstet Gynecol. 1990; 162: 525–8.

    PubMed  CAS  Google Scholar 

  25. Romero R, Parvizi ST, Oyarzun E, et al. Amniotic fluid interleukin-1 in spontaneous labor at term. J Reprod Med. 1990; 35: 235–8.

    PubMed  CAS  Google Scholar 

  26. Challis J, Riley SC, Yang K. Endocrinology of labour. Fetal Med Rev. 1991; 3: 47–66.

    Article  Google Scholar 

  27. McLean M, Bissetts A, Davies J, Woods R, Lowery P, Smith R. A placental clock controlling the length of gestation. Nature Med. 1995; 18: 234–6.

    Google Scholar 

  28. Cheung PYC, Challis JRG. Prostaglandin E2 metabolism in the human fetal membranes. Am J Obstet Gynecol. 1989; 16: 1580–5.

    Google Scholar 

  29. Nakla S, Skinner K, Mitchell BF, Challis JRG. Changes in prostaglandin transfer across human fetal membranes obtained following spontaneous labour. Am J Obstet Gynecol. 1986; 155: 1337–41.

    PubMed  CAS  Google Scholar 

  30. Bennett PR, Chamberlain GVP, Patel L, Elder MG, Myatt L. Mechanisms of parturition; the transfer of prostaglandin E2 and 5–HETE across fetal membranes. Am J Obstet Gynecol. 1990; 162: 683–7.

    PubMed  CAS  Google Scholar 

  31. Roseblade CK, Sullivan MF, Khan H, Lumb MR, Elder MG. Limited transfer of prostaglandin E2 across fetal membranes before and after labour. Acta Obstet Gynecol Scand. 1990; 69: 399–403.

    Article  PubMed  CAS  Google Scholar 

  32. Khan H, Ishihara O, Sullivan MHF, Elder MG. A comparison of two populations of decidual cells by immunocytochemistry and prostaglandin production. Histochemistry. 1991; 96: 149–52.

    Article  PubMed  CAS  Google Scholar 

  33. Bamford DS, Jogee M, Williams K. Prostacyclin formation by the human pregnant myometrium. Br J Obstet Gynaecol. 1980; 87: 215–18.

    Article  PubMed  CAS  Google Scholar 

  34. Casey LM, McDonald PC, Mitchell MD. Despite a massive increase in cortisol secretion in women during parturition there is an equally massive increase in prostaglandin synthesis: A paradox? J Clin Invest. 1985; 75: 1852–7.

    Article  PubMed  CAS  Google Scholar 

  35. Bennett PR, Elder MG, Myatt L. The effects of lipoxygenase metabolites of arachidonic acid upon contractility of human pregnant myometrium in vitro. Prostaglandins. 1988; 33: 837–44.

    Article  Google Scholar 

  36. Bryman I, Hammerstromm S, Linblomm B, Norstrom A, Wickland M, Wiquest N. Leukotrienes and myometrial activity in the term pregnancy uterus. Prostaglandins. 1985; 30: 907–13.

    Article  PubMed  CAS  Google Scholar 

  37. Walsh SW. 5–Hydroxyeicosatetraenoic acid, leukotriene C4 and prostaglandin Fla in amniotic fluid before and during term and preterm labor. Am J Obstet Gynecol. 1989; 161: 1352–60.

    Google Scholar 

  38. Leak RD, Wiesman RE, Glatz TH, Fisher DA. Stimulation of oxytocin secretion in the human. Clin Res. 1979; 27: 99A.

    Google Scholar 

  39. Fuchs AR, Goeschen K, Husslien P, Fuchs F. Oxytocin and the initiation of human parturition; Concentrations of oxytocin and prostaglandin F in spontaneous and oxytocin induced labor at term. Am J Obstet Gynecol. 1983; 147: 497–502.

    PubMed  CAS  Google Scholar 

  40. Dawood MY. Neurohypophysial hormones. In: Fuchs F, Klopper A, eds. Endocrinology of pregnancy. New York: Harper and Row; 1983: 204–88.

    Google Scholar 

  41. Sbarra AJ, Selvaraj RJ, Cetrulo CL, Thomas G, Louis F, Kennison R. Phagocytosis and the onset of human labor. Am J Obstet Gynecol. 1983; 146: 622–9.

    PubMed  CAS  Google Scholar 

  42. Wilson T, Liggins GC, Aimer GP, Skinner SJ. Partial purification and characterisation of two compounds from amniotic fluid which inhibit phospolipase activity in human endometrial cells. Biochem Biophys Res Commun. 1985; 131: 22–9.

    Article  PubMed  CAS  Google Scholar 

  43. Grieves SA, Liggins GC. Phospholipase A activity in human and ovine uterine tissues. Prostaglandins. 1976; 12: 229–41.

    Article  PubMed  CAS  Google Scholar 

  44. Bleasdale JE, Johnston JM. Prostaglandins and human parturition: regulation of arachidonic acid mobilisation. Rev Perinatal Med. 1984; 5: 157–91.

    Google Scholar 

  45. Okita JR, MacDonald PC, Johnston JM. Mobilization of arachidonic acid from specific glycerophospholipids of human fetal membranes during early labour. J Biol Chem. 1982; 257: 14029–34.

    PubMed  CAS  Google Scholar 

  46. Dennis EA. Regulation of eicosanoid production: Role of phospholipases and inhibitors. Biotechnology. 1987; 5: 1294–301.

    Article  CAS  Google Scholar 

  47. Di Renzo GC, Johnston JM, Okazaki T, Okita JR, MacDonald PC, Bleasedale JE. Phosphatidylinositol specific phospholipase C in fetal membranes and uterine decidua. J Clin Invest. 1981; 67: 847–51.

    Article  PubMed  Google Scholar 

  48. Okazaki T, Sagawa N, Bleasedale JE, Okita JR, MacDonald PC, Johnston JM. Initiation of human parturition. XIII. Phospholipase C, phospholipase Az and diacylglycerol lipase activities in fetal membranes and decidua vera tissues from early and late gestation. Biol Reprod. 1981; 25: 103–8.

    Article  PubMed  CAS  Google Scholar 

  49. Lopez Bemal A, Newman GE, Phizackerley PJR, Bryant–Greenwood G, Keeling JW. Human placental phospholipase A2 activity in term and preterm labour. Eur J Obstet Gynaecol Reprod Biol. 1992; 43: 185–92.

    Article  Google Scholar 

  50. Aitken MA, Rice GE, Brennecke SP. Gestational tissue phospholipase A2 mRNA content and the onset of spontaneous labour in humans. Reprod Fert Dev. 1992; 2: 575–80.

    Article  Google Scholar 

  51. Bennett PR, Slater D, Moore GE. Expression of common cellular phospholipase A2 by human intrauterine tissues. Prostaglandins. 1993; 45: 121–7.

    Article  PubMed  CAS  Google Scholar 

  52. Clark JD, Milona N, Knopf JL. Purification of a 1 l0-kilodalton cytosolic phospholipase AZ from human monocytic cell line U937. Proc Natl Acad Sci USA. 1990; 87: 7708–12.

    Article  PubMed  CAS  Google Scholar 

  53. Mayer RJ, Marshall LA. New insights on mammalian phospholipase A2(s); comparison of arachidonyl–selective and –nonselective enzymes. FASEB J. 1993; 7: 339–48.

    PubMed  CAS  Google Scholar 

  54. Slater D, Berger L, Sullivan M, Bennett PR. Differential expression of phospholipases A2 in placenta and fetal membranes and changes in expression with the onset of labour. Am J Obstet Gynecol. [in press].

    Google Scholar 

  55. Xue S, Myatt L. Abstract. Chicago: The Society for Gynaecological Investigations; 1994.

    Google Scholar 

  56. Rajasingam D, Slater D, Sullivan M, Elder MG, Bennett PR. Changes in phospholipase expression induced by LPS treatment of fetal membranes. Am J Obstet Gynecol [in press].

    Google Scholar 

  57. Lin L, Lin AY, Knopf JL. Cytosolic phospholipase A2 is coupled to hormonally regulated release of arachidonic acid. Proc Natl Acad Sci USA. 1992; 89: 6147–51.

    Article  PubMed  CAS  Google Scholar 

  58. Nemenoff RA, Winitz S, Qian NX, van Putten V, Johnson GL, Heasley LE. Phosphorylation and activation of a high molecular weight form of phospholipase A2 by p42 microtubule–associated protein 2 kinase and protein kinase C. J Biol Chem. 1993; 268: 1960–4.

    PubMed  CAS  Google Scholar 

  59. Lin L, Wartmann M, Lin AY, Knopf JL, Seth A, Davis RJ. cPLAZ is phosphorylated and activated by MAP kinase. Cell. 1993; 72: 269–78.

    Article  PubMed  CAS  Google Scholar 

  60. Schlaepfer DD, Haigler HT. Characterisation of Ca2, –dependent phospholipid binding and phosphorylation of lipocortin I. J Biol Chem. 1987; 262: 6931–7.

    PubMed  CAS  Google Scholar 

  61. Lynch–Salamon DI, Everson WV, Myatt L. Decrease in annexin I messenger ribonucleic acid expression in human amnion with labour. Am J Obstet Gynecol. 1992; 167: 1657–63.

    Google Scholar 

  62. Myatt L, Hirth J, Everson WV. Changes in annexin (lipocortin) content in human amnion and chorion at parturition. J Cell Biochem. 1992; 50: 363–73.

    Article  PubMed  CAS  Google Scholar 

  63. Blackwood RA, Ernst JD. Characterisation of Ca’–dependent phospholipid binding, vesicle aggregation and membrane fusion between enzyme and inhibitor. J Biol Chem. 1990; 266: 195–200.

    CAS  Google Scholar 

  64. Marshall PJ, Kulmacz RJ, Lands WEM. Constraints on prostaglandin synthesis in tissues. J Biol Chem. 1987; 262: 3510–7.

    PubMed  CAS  Google Scholar 

  65. Bennett PR, Henderson DJ, Moore GE. Changes in the expression of cyclo–oxygenase in human fetal membranes and placenta with labour. Am J Obstet Gynecol. 1992; 167: 212–6.

    PubMed  CAS  Google Scholar 

  66. DeWitt DL, Smith WL. Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complimentary DNA sequence. Proc Natl Acad Sci USA. 1988; 85: 1412–6.

    Article  PubMed  CAS  Google Scholar 

  67. Smieja Z, Zakar T, Waton JC, Olson DM. Prostaglandin endoperoxide synthase kinetics in human amnion before and after labour at term and following preterm labour. Placenta. 1993; 14: 163–75.

    Article  PubMed  CAS  Google Scholar 

  68. Smith WL, Marnett LN. Prostaglandin endoperoxide synthase: structure and catalysis. Biochim Biophys Acta. 1991; 1083: 1–17.

    PubMed  CAS  Google Scholar 

  69. O’Baion MK, Sadowski HB, Winn W, Young DA. A serum and glucocorticoid regulated 4kb mRNA encodes a cyclo-oxygenase related protein. J Biol Chem. 1991; 266: 23261–7.

    Google Scholar 

  70. Jones DA, Carlton DP, McIntyre TM, Zimmerman GA, Prescott SM. Molecular cloning of human prostaglandin endoperoxide synthase type II and demonstration of expression in response to cytokines. J Biol Chem. 1993; 268: 9049–54.

    PubMed  CAS  Google Scholar 

  71. Slater DM, Berger L, Newton R, Moore GE, Bennett PR. The relative abundance of type I to type 2 cyclo–oxygenase mRNA in human amnion at term. Biochem Biophys Res Commun. 1994; 198: 304–8.

    Article  PubMed  CAS  Google Scholar 

  72. Slater DM, Berger L, Newton R, Moore GE, Bennett PR. Changes in the expression of types 1 and 2 cyclo-oxygenase in human fetal membranes at term. Am J Obstet Gynecol. 1995; 172: 77–82.

    Article  PubMed  CAS  Google Scholar 

  73. Moore S, Burke S, Slater D, Myatt L. Expression of prostaglandin–H synthase isoforms in human myometrium at parturition. Am J Obstet Gynecol. [in press].

    Google Scholar 

  74. Bailey JM, Verma M. Analytical procedures for a cryptic mRNA which mediates translational control of prostaglandin synthesis by glucocorticoids. Ann Biochem. 1991; 196: 11–8.

    Article  CAS  Google Scholar 

  75. Pash JM, Bailey JM. Inhibition by corticosteroids of epidermal factor–induced recovery of cyclooxygenase after aspirin inactivation. FASEB J. 1988; 2: 2613–8.

    PubMed  CAS  Google Scholar 

  76. Bailey JM. Mini review: New mechanisms for effects of anti-inflammatory glucocorticoids. Biofactors. 1991; 3: 97–102.

    PubMed  CAS  Google Scholar 

  77. Bailey JM, Verma M. Identification of a highly conserved 3’UTR in the translational regulated mRNA for prostaglandin synthase. Prostaglandins. 1990; 40: 585–90.

    Article  PubMed  CAS  Google Scholar 

  78. Norton ME, Merrill J, Cooper BA, et al. Neonatal complications after administration of indomethacin for preterm labour. N Engl J Med. 1993; 329: l602–7.

    Article  Google Scholar 

  79. Kirshon B, Moise KJ, Mari G, Willis R. Long term indomethacin therapy decreases fetal urine output and causes oligohydramnios. Am J Perinatol. 1991; 8: 86.

    Article  PubMed  CAS  Google Scholar 

  80. Moise KJ. Effect of advancing gestational age on the frequency of fetal ductal constriction in association with maternal indomethacin usage. Am J Obstet Gynecol. 1983; 168: 1350–53.

    Google Scholar 

  81. Enkin MW, Keirse MJNC, Renfrew MJ, Nielson JP, eds. The pregnancy & childbirth module. Chochrane Database of Systematic Reviews, Cochrane Collaboration; 1995.

    Google Scholar 

  82. Slater D, Bennett PR. Changes in expression of cyclooxygenase types I and II throughout pregnancy. Am J Obstet Gynecol [in press].

    Google Scholar 

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  1. P. Bennett
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  2. D. Slater
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Editors and Affiliations

  1. The William Harvey Research Institute, Saint Bartholomew’s Hospital Medical College, London, UK

    John Vane , Jack Botting  & Regina Botting ,  & 

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Bennett, P., Slater, D. (1996). COX-2 expression in labour. In: Vane, J., Botting, J., Botting, R. (eds) Improved Non-Steroid Anti-Inflammatory Drugs: COX-2 Enzyme Inhibitors. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-9029-2_10

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  • DOI: https://doi.org/10.1007/978-94-010-9029-2_10

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-9031-5

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