• E. S. Sachs


Down’s syndrome patients have an extra G chromosome in all their cells, whereas the trisomy G/normal mosaic patients have this extra chromosome only in some of their cells. For this reason, a direct relationship between any measurable sign of Down’s syndrome and the extra G chromosome could be expected to result in an occurrence of that sign in mosaic patients in a degree proportional to the percentage of trisomic cells, while non-measurable clinical signs would only appear in a percentage of mosaic patients.

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© Springer Science+Business Media Dordrecht 1971

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  • E. S. Sachs

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