Pancreatic Glucagon, and Glucagon-Like Material in Tissues and Plasmas from Human Foetuses 6–26 Weeks Old

  • R. Assan
  • J. Boillot
Part of the Nutricia Symposium book series (NUSY, volume 3)


Determination of the first appearance of glucagon in the human fetal pancreas is of some interest from an organo-genetic point of view.


Human Foetus Glucagon Secretion Alpha Cell Immunoassay System Glucagon Concentration 
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  1. 1.
    ASSAN, R., Glucagon and glucagon cross-reacting substances in gastric (G.E.) and pancreatic (P.E.) extracts from 12 animals species. 3rd Intern. Congress of Endocrinol. Mexico 1968, Abstract Excerpta Med. Found, Amsterdam 1968.Google Scholar
  2. 2.
    HEDING, L. G., (1969) The production of glucagon antibodies in rabbits. Hormone Metab. Res. 1:87–88.CrossRefGoogle Scholar
  3. 3.
    LIU, H. M.-POTTER E. L., (1962) Development of the human pancreas. Arch. Pathol. 74:439–452.Google Scholar
  4. 4.
    ROBB, R., (1961) The development of the islets of Langerhans in man. Arch. Dis. Child. 36:229–230.Google Scholar
  5. 5.
    EMERY, J. L., H. P. R. BURY, (1964) Involutionary changes in the islets of Langerhans. Biol. Neonatorum 1964, 6:15–26.Google Scholar
  6. 6.
    ORCI, L., E. LAMBERT, Ch. ROUILLER, A. E. RENOLD, E. SAMOLS, (1969) Evidence for the presence of A-cells in the endocrine fetal pancreas of the rat. Hormone Metab. Res. 1:108–110.CrossRefGoogle Scholar
  7. 7.
    PERRIER, H., A. PORTE, R. JACQUOT, (1969) Présence de cellules A dans le pancréas foetal de rat. C. R. Acad. Sc. Paris 269:841–843.Google Scholar
  8. 8.
    ZAGURY, D., (1961) Contribution à l’étude morphologique des sécrétions pancréatiques chez le rat. Ann. Sci. Nat. Zool. I2ème série, 111:186–296.Google Scholar
  9. 9.
    RUTTER, W. J., (1969) Independantly regulated synthetic transitions in fetal tissues in: ‘fetal Atonomy’ Ciba Found, coll. CHURCHILL, J. A., London, Ed. WOLTERNHOLME, G. E. W., M. O’CONNOR, p. 59–78.Google Scholar
  10. 10.
    ALEXANDER, P., R. ASSAN, D. NIXON, and coll. under press.Google Scholar
  11. 11.
    BARNES, A. C. (1968) Intra-uterine development, vol. 1, Lea Febiger Ed., Philadelphia, p. 530.Google Scholar
  12. 12.
    BLUM, D., J. DODION, H. LOEB, P. WILKIN, P. O. HUBINON, (1969). Studies on hypoglycemia in small-for-dates newborns. Arch. Dis. Child. 44: 304–310.PubMedCrossRefGoogle Scholar
  13. 13.
    BROCK, L. C., W. R. CLARK, R. H. WILLIAMS, W. RUTTER, (1969) Embryonic development of the endocrine pancreas: I Analysis of hormonal levels. Diabetes, 18, 321.Google Scholar
  14. 14.
    CONKLIN, J. S., The development of the pancreas of the human foetus. Ann Arbor, Michigan University Microfilm Inc., Cat no 61, 2739.Google Scholar
  15. 15.
    CORNBLATH, M., R. SCHWARTZ, (1966) Disorders of carbohydrate metabolism in infancy. Saunders., Philadelphia, p. 297.Google Scholar
  16. 16.
    DAWES, G. S., H.J. SHELLEY, (1968) Carbohydrate metabolism in foetus and newborn. In Carbohydrate metabolism and its disorders, vol. 2, DICKENS, F. P. J. RäNDLE, Ed. WHEELAN, Academic Press, London, New-York, p. 87–121.Google Scholar
  17. 17.
    FERNER, H., W. STOECKENIUS, (1951) Die cytogenese des Inselsystems beim Menschen. Z Zellforsch Mikr. Anat. 35:147–175.CrossRefGoogle Scholar
  18. 18.
    GIRARD, J., D. BAL, (1970) Effets du glucagon-zinc sur la glycémie et la teneur en glycogène du foie foetal du rat en fin de gestation. C. R. Acad. Sci. Paris, 271: 777–779.Google Scholar
  19. 19.
    GRILLO, T. A. I., K. SHIMA, (1966) Insulin content and enzyme histochemistry of the human fetal pancreatic islet. J. Endocrinol. 36:151–158.PubMedCrossRefGoogle Scholar
  20. 20.
    MACLEAN, N., R. F. OGILVIE, (1955) Quantitative estimate of pancreatic islet tissue in diabetic subjects. Diabetes, 4/5:367.PubMedGoogle Scholar
  21. 21.
    MESSINA, A., G. REITANO, S. GRASSO, N. SAPORITO, (1968) Effetti del glucagone solla secrezione insulinica del neonato immaturo. Voll. Soc. Ital. Biol. Sper., XLIV: 2015–2018.Google Scholar
  22. 22.
    MILNER, R. D. G., (1969) The secretion of insulin from fetal and post natal rabbit pancreas in vitro in response to various substances. J. Endocrinol. 44:267–272.PubMedCrossRefGoogle Scholar
  23. 23.
    MUNGER, B. L., (1958) A light and electron microscopic study of cellular differentiation in the pancreatic islet of the mouse. Amer. J. Anat. 103:275–311.PubMedCrossRefGoogle Scholar
  24. 24.
    PEARCE, R. M., (1903) The development of the island of Langerhans in the human embryon. Amer. J. Anat. 2:445–455.CrossRefGoogle Scholar
  25. 25.
    SCHULTZE-JENA, B. S., (1953) Das quantitative und qualitative Inselbild menschlicher feten und neugeborenen. Virchows Arch. Path. Anat. Physiol. 323: 653–663.CrossRefGoogle Scholar
  26. 26.
    VAN ASSCHE, F. A., (1968) A morphological study of the Langerhans islets of the fetal pancreas in late pregnancy. Biol. Neonatorum, 12:331–342.CrossRefGoogle Scholar
  27. 27.
    WEICHSELBAUM, A., J. KYRLE, (1909) Uber das verhalten der Langerhansschen insulin der menschlichen pankreas im fötalen und post fötalen leben. Arch. Mikrosk. Anat. Int. Med. 74:223–258.CrossRefGoogle Scholar

Copyright information

© H. E. Stenfert Kroese N.V. Leiden Holland 1971

Authors and Affiliations

  • R. Assan
  • J. Boillot
    • 1
  1. 1.Hôtel-Dieu — Place du ParvisNotre-Dame - 75 -ParisFrance

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