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The Effects of Early Hypothyroidism on iq, School Performance, and Electroencephalogram Pattern in Children

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Normal and Abnormal Development of Brain and Behaviour

Part of the book series: Boerhaave Series for Postgraduate Medical Education ((BSPM,volume 6))

Abstract

Congenital hypothyroidism in man offers a naturally occurring biological model for the study of brain-thyroid relationships during the formative period of the central nervous system.

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References

  1. Siegert, F., Myxödem im Kindesalter. Ergeh, inn. Med. Kinderh. 6, 601 (1910).

    Google Scholar 

  2. Eayrs, J. T. & Taylor, S. H., The effect of thyroid deficiency induced by methyl-thiouracil on the maturation of the central nervous system. J. Anat. 85, 350 (1951).

    PubMed  CAS  Google Scholar 

  3. Eayrs, J. T., The cerebral cortex of normal and hypothyroid rats. Acta anat. 25, 160 (1955).

    Article  PubMed  CAS  Google Scholar 

  4. Eayrs, J. T., The status of the thyroid gland in relation to the development of the nervous system. Anim. Behav. 7, 1 (1959).

    Article  Google Scholar 

  5. Eayrs, J. T., Influence of the thyroid on the central nervous system. Brit. med. Bull 16, 122 (1960).

    PubMed  CAS  Google Scholar 

  6. Eayrs, J. T., Thyroid and central nervous development. In: The scientific basis of medicine, London 1966.

    Google Scholar 

  7. Legrand, J., Kriegel, A. & Jost, A., Déficience thyroîdienne et maturation du cervelet chez le rat blanc. Arch. Anat. Microsc. Morphol. Exp. 50, 507 (1961).

    CAS  Google Scholar 

  8. Balâzs, R., Brooksbank, B. W. L., Davison, A. N., Eayrs, J. T. & Wilson, D. A., The effect of neonatal thyroidectomy on myelination in the rat brain. Brain Res. 15, 219 (1969).

    Article  PubMed  Google Scholar 

  9. Balâzs, R., Kóvacs, S., Teichgräber, P., Cocks, W. A. & Eayrs, J. T., Biochemical effects of thyroid deficiency on the developing brain. J. Neurochem. 15, 1335 (1968).

    Article  PubMed  Google Scholar 

  10. Eayrs, J. T. & Levine, S., Influence of thyroidectomy and subsequent replacement therapy upon conditioned avoidance learning in the rat. J. Endocrinol. 25, 505 (1963).

    Article  Google Scholar 

  11. Marinesco, M.G., Contribution à l’étude des lésions du myxoedème congénital. Encéphale 19: 265 (1924).

    Google Scholar 

  12. Lotmar, F., Histopathologische Befunde in Gehirnen vom kongenitalen Myxödem (Thyreoplasie). Z. ges. Neur. Psychiat., 491 (1929).

    Google Scholar 

  13. Eayrs, J. T., Functional correlates of modified cortical structure. In: Structure and function of the cerebral cortex, Tower, D. B. & Schadé, J. P. (eds.), Amsterdam 1960.

    Google Scholar 

  14. Sokoloff, L., Roberts, P. A., Januska, M. M. & Kline, J. E., Mechanisms of stimulation of protein synthesis by thyroid hormones in vivo. Proc. Nat. Acad. Sci. 60, 652 (1968).

    Article  PubMed  CAS  Google Scholar 

  15. Fisher, D. A., Lehman, H. & Lackey, C., Placental transport of thyroxine. J. Clin. Endocrinol. 24, 393 (1964).

    Article  CAS  Google Scholar 

  16. Pickering, D. E., Maternal thyroid hormone in the developing fetus. (Observations on Macaca Mulatta). Amer. J. Dis. Child. 107, 567 (1964).

    PubMed  CAS  Google Scholar 

  17. Dobbing, J. & Sands, J., Timing of neuroblast multiplication in developing human brain. Nature 226, 639 (1970).

    Article  PubMed  CAS  Google Scholar 

  18. Winick, N., Changes in nucleic acid and protein content of the human brain during growth. Pediat. Res. 2, 352 (1968).

    PubMed  CAS  Google Scholar 

  19. Smith, D. W., Blizzard, R. M. & Wilkins, L., The mental prognosis in hypothyroidism of infancy and childhood. Pediatrics 19, 1011 (1957).

    PubMed  CAS  Google Scholar 

  20. Bernheim, M., Berger, M., Bertrand, J. & Frederich, A., Le pronostic du myxoedème congénital. Presse méd. 69, 2182 (1961).

    PubMed  CAS  Google Scholar 

  21. Andersen, H. J., Studies of hypothyroidism in children. Acta paed. 50, suppl. 125 (1961).

    Article  Google Scholar 

  22. Andersen, H. & Skinhøj, K., Longitudinal studies of I.Q. in hypothyroid children during treatment. Proc. intern. Copenhagen congress on the scientific study of mental retardation, vol. II. 1964.

    Google Scholar 

  23. Chorus, A., Bekker, F. J., Kuipers, A., Koornstra, M. & Gemund, J. J. van. On the occurrence and prevention of mental deficiency in hypothyroidism. Proc. intern. Copenhagen congress on the scientific study of mental retardation, vol. I. 1964.

    Google Scholar 

  24. Wilkins, L., The diagnosis and treatment of endocrine disorders in childhood and adolescence, Springfield (Ill.) 1965.

    Google Scholar 

  25. Hutchison, J. H., Diseases of the thyroid gland. In: Paediatric endocrinology, Hubble, D. (ed,), Oxford 1969.

    Google Scholar 

  26. Ross, D. A. & Schwab, R. S., The cortical alpha rhythm in thyroid disorders. Endocrinology 25, 75 (1939).

    Article  Google Scholar 

  27. d’Avignon, M. & Melin, K. A., The electroencephalogram in congenital hypothy-reosis. ActaPaed. 38, 37 (1949).

    Google Scholar 

  28. Nieman, E. A., The electroencephalogram in congenital hypothyroidism: a study of 10 cases. J. Neurol. Neurosurg. Psychiat. 24, 50 (1961).

    Article  PubMed  CAS  Google Scholar 

  29. Lansing, R. W. & Trunnell, J. B., Electroencephalographic changes accompanying thyroid deficiency in man. J. Clin. Endocrinol. 23, 470 (1963).

    Article  CAS  Google Scholar 

  30. Harris, R., Della Rovere, M. & Prior, P. F., Electroencephalographic studies in infants and children with hypothyroidism. Arch. Dis. Child. 40, 612 (1965).

    Article  PubMed  CAS  Google Scholar 

  31. Bradley, P. B., Eayrs, J. T. & Schmalbach, K., The electroencephalogram of normal and hypothyroid rats. Electroenceph. Clin. Neurophysiol. 12, 467 (1960).

    Article  PubMed  CAS  Google Scholar 

  32. Dreyfus-Brisac, C., Samson-Dollfus, D. & Fischgold, H., L’activité électrique cérébrale du prématuré et du nouveau-né. Sem. Hôp. Paris 31, 1783 (1955).

    PubMed  CAS  Google Scholar 

  33. Dreyfus-Brisac, C., The electroencephalogram of the premature infant and full-term newborn. In: Neurological and electroencephalographic correlative studies in infancy, Kellaway, P. & Petersén, I. (eds.), New York 1964.

    Google Scholar 

  34. Samson-Dollfus, D., Forthomme, J. & Capron, E., EEG of the human infant during sleep and wakefulness during the first year of life. In: Neurological and electroencephalographic correlative studies in infancy, Kellaway, P. & Petersén, I. (eds.), New York 1964.

    Google Scholar 

  35. Lenard, H. G., Sleep studies in infancy. ActaPaed. Scand. 59, 572 (1970).

    Article  CAS  Google Scholar 

  36. Lenard, H. G., The development of sleep spindles in the EEG during the first two years of life. Neuropädiat. 1, 264 (1970).

    Article  CAS  Google Scholar 

  37. Schultz, M. A., Schulte, F. J., Akiyama, Y. & Parmelee, A. H., Development of electroencephalographic sleep phenomena in hypothyroid infants. Electroenceph. Clin. Neurophysiol. 25, 351 (1968).

    Article  PubMed  CAS  Google Scholar 

  38. Schulte, F. J. & Parmelee, A. H., Thyroid hormone and brain development. An analysis of polygraphic data of hypothyroid babies before and during treatment (abstr.). Electroenceph. Clin. Neurophysiol. 29, 212 (1970).

    PubMed  CAS  Google Scholar 

  39. Lewis, A., A study of cretinism in London, with special reference to mental development and problems of growth. Lancet 1, 1505 (1937).

    Article  Google Scholar 

  40. Topper, A., Mental achievement of congenitally hypothyroid children. Amer. J. Dis. Child. 81, 233 (1951).

    CAS  Google Scholar 

  41. Harnack, G. A. von & Wallis, H., Zur Psychopathologie der Hypothyreose im Kindesalter. Monatsschr. Kinderheilk. 108, 373 (1960).

    Google Scholar 

  42. Neimann, N., Pierson, M. & Berthier, X., Le pronostic mental du myxoedème infantile. Arch. Franc. Pédiat. 20, 147 (1963).

    PubMed  CAS  Google Scholar 

  43. König, M. P., Die kongenitale Hypothyreose und der endemische Kretinismus, Berlin 1968.

    Google Scholar 

  44. Money, J., Psychologic studies in hypothyroidism. Arch. Neurol. Psychiat. 76, 296 (1956).

    CAS  Google Scholar 

  45. Hagberg, B. & Westphal, O., Ataxic syndrome in congenital hypothyroidism. Acta Paed. Scans. 59, 323 (1970).

    Article  CAS  Google Scholar 

  46. Money, J. & Lewis, V., Longitudinal study of intelligence quotient in treated congenital hypothyroidism. In: Brain-thyroid relationships, Ciba Foundation Study Group nr. 18, London 1964.

    Google Scholar 

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© 1971 Leiden University Press, Leiden, The Netherlands

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Van Gemund, J.J., De Angulo, M.S.L. (1971). The Effects of Early Hypothyroidism on iq, School Performance, and Electroencephalogram Pattern in Children. In: Stoelinga, G.B.A., Van Der Werff Ten Bosch, J.J. (eds) Normal and Abnormal Development of Brain and Behaviour. Boerhaave Series for Postgraduate Medical Education, vol 6. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-2921-6_19

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  • DOI: https://doi.org/10.1007/978-94-010-2921-6_19

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-2923-0

  • Online ISBN: 978-94-010-2921-6

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