Fundus Flavimaculatus associated with Polycystic Kidney Disease: another Oculo-Renal Disorder?

Abstract

A 47 year old woman was referred by her internist because of progressive bilateral visual loss. The patient’s family history was significant in that her father died in his 40s of kidney disease, and the patient had one male and two female cousins who died of kidney disease. Her own long-standing renal disease was first clinically recognized in 1950, when she underwent a right nephrectomy for polycystic disease. She did reasonably well until 1967, when she developed progressive renal failure. In November, 1970, she underwent a cadaveric renal transplant, which was subsequently rejected, and had to be surgically removed later that same month. In March, 1971, the patient received her second cadaveric renal transplant, which functioned well until early 1973. From the time of her second kidney transplant, she had received a variety of medications, including azathioprine (150 mg/day), prednisone (20–80 mg/day), INH (300 mg/day), cycloheptadine hydrochloride (60 mg/day), chlorpheniramine maleate, and ascorbic acid. The patient was hypertensive both before and after her kidney transplant. She was maintained on varying doses of furosemide and methyldopa.