Abstract
The response of 5-halogen substituted analogs of the nucleic acid base uracil to excitation by UV-light or ionizing radiation is a topic of interest in radiation biology since nearly two decades. These components and their nucleoside(-tide) derivatives, (I), can be incorporated into DNA of actively proliferating cells in place of the corresponding thymine residues. Irradiation of cells containing the halogenated analogs produces an up to four-fold increase in lethal, biological damage.
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References
F. Hutchinson, Quart.Rev.Biophys. 6, 201 (1973).
W. Szybalski, Cancer Chemotherapy Reports Part 1, 58, 539 (1974).
P. Neta, J.Phys.Chem. 76, 2399 (1972).
J.D. Zimbrick, J.F.B Ward, and L.S. Myers, Jr., Int.J.Radiat.Biol. 16, 505 (1969).
Program MAGNSPEC3. QCPE 150 (Indiana University, Chemistry Dept.).
J. Hüttermann and A. Müller, Int.J.Radiat.Biol. 4, 297 (1969).
W. Neumüller, Thesis (University of Regensburg), (1976).
H. Oloff and J. Hüttermann, J.Magn.Res., in press (1977).
R.A. Farley and W.A. Bernhard, Radiat.Res. 61, 47 (1975).
W.A. Bernhard, D.M. Close, J. Hüttermann, and H. Zehner, J.Chem.Phys., in press (1977).
H.C. Box and E.E. Budzinski, J.Chem.Phys. 62, 197 (1975).
R. Bergene and R.A. Vaughan, Int.J.Radiat.Biol. 29 14–5 (1976).
J. Hüttermann, W.A. Bernhard, E. Haindl, and G. Schmidt, Int.J.Radiat.Biol., submitted for publication.
J. Hüttermann, W.A. Bernhard, E. Haindl, and G. Schmidt, J.Phys.Chem., in press (1977).
J. Hüttermann, W.A. Bernhard, E. Haindl, and G. Schmidt, Mol.Phys. 32, 1111 (1976).
E. Haindl and J. Hüttermann, J.Magn.Res., submitted for publication.
J. Huttermann, G.W. Neilson, and M.C.R. Symons, Mol.Phys. 32, 269 (1976).
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Hüttermann, J. (1977). Excitation and Ionization of 5-Halouracils: ESR and ENDOR of Single Crystals. In: Pullman, B., Goldblum, N. (eds) Excited States in Organic Chemistry and Biochemistry. The Jerusalem Symposia on Quantum Chemistry and Biochemistry, vol 10. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-1273-7_8
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DOI: https://doi.org/10.1007/978-94-010-1273-7_8
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