Abstract
Interaction of alkali and alkaline earth metal ions is of significance to the biophysical chemistry of proteins and polypeptides. Effect of salts are now known to involve binding with specific sites rather than general effects or alteration of water (solvent) structure [1–4]. Such specific interactions would be important to consider in conformational transitions of polypeptides, denaturation of proteins, selective ion complexation by macrocyclic anti-biotic ionophores etc. Lithium salts are also known to affect brain chemistry [5]. Interaction of protons with the peptide bond (protonation) is of considerable importance in understanding helix-coil transitions of proteins and related phenomena [1, 6]. In this paper, we present the results of theoretical and spectro-scopic investigations carried out in this laboratory on the interaction of alkali and alkaline earth ions as well as protons on model amides and related systems. These studies have provided the relative strengths of interaction of these cations and the consequences of such interaction on the structure and spectra of the donor molecules. Vibrational, electronic and nuclear magnetic resonance spectra of the metal ion adducts have been examined.
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© 1977 D. Reidel Publishing Company
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Rao, C.N.R. (1977). Interaction of Alkali and Alkaline Earth Cations and Protons with Amides and Related Systems. In: Pullman, B., Goldblum, N. (eds) Metal-Ligand Interactions in Organic Chemistry and Biochemistry. The Jerusalem Symposia on Quantum Chemistry and Biochemistry, vol 9-1. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-1170-9_10
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DOI: https://doi.org/10.1007/978-94-010-1170-9_10
Publisher Name: Springer, Dordrecht
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