Abstract
One of the basic prerequisites for normal haemoglobin synthesis is a regulated supply of substrates to systems producing haem (mitochondria) as well as globin (ribosomes). For the formation of the protein component of haemoglobin all amino acids arc essential. On the other hand for the synthesis of the prosthetic group — haem — iron, glycine and succinyl-cocnzymc A arc needed. Succinyl-cocnzymc A is present in non-limiting amounts due to the metabolic activity of mitochondria (see p. 60). While amino acids are available in a free form, iron is bound to its protein carrier — transferrin.
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© 1977 Martinus Nijhoff
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Neuwirt, J., Poňka, P. (1977). Substrate Supply for Haemoglobin Synthesis. In: Regulation of Haemoglobin Synthesis. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-1090-0_2
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DOI: https://doi.org/10.1007/978-94-010-1090-0_2
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-1092-4
Online ISBN: 978-94-010-1090-0
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