Requirements for protein and amino acids: applications to parenteral nutrition

  • Hamish N. Munro

Abstract

In several clinical conditions, such as cancer, injury, burning, and malabsorption, there is often significant loss of body protein, and in some other diseases, notably hepatic cirrhosis and uremia, there are abnormalities of protein metabolism. In the treatment of all these conditions, the maintenance or restoration of body protein content and the correction of metabolic abnormalities become major therapeutic objectives. In order to reverse these pathological changes in protein metabolism, an important strategy is the adjustment of the diet, and a potent way of ensuring this is by parenteral nutrition. It is therefore important to design nutritional treatment for these various clinical conditions along lines that will take advantage of our current knowledge of protein metabolism and protein requirements. This contribution to the symposium will describe three areas of significance for these objectives:
  1. (i)

    current concepts of the regulation of protein metabolism in the body ;

     
  2. (ii)

    requirements by normal subjects for protein and amino acids, alterations in requirements caused by disease and modifications in nutrient intake that may be required for delivery by the parenteral route ;

     
  3. (iii)

    parameters for measuring protein depletion and repletion.

     

Keywords

Burning Cortisol Glutamine Trypsin Tryptophan 

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Copyright information

© Martinus Nijhoff Medical Division The Hague 1977

Authors and Affiliations

  • Hamish N. Munro
    • 1
  1. 1.BostonUSA

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