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Clinical Trials in Transplant Immunosuppression: What Have We Learned?

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Current and Future Immunosuppressive Therapies Following Transplantation

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Abstract

Evidence-based medicine relies on clinical trials, which are mandatory prior to the introduction of novel therapeutic strategies into clinical practice. The experimental design most appropriate for the comparison of therapeutic intervention is the randomized controlled clinical trial. These trials are designed to assess the efficacy of treatment in quantitative terms which are frequency of defined events (primary end-points) and time course of disease. Randomization minimizes selection bias and prevents bias in the comparison between study groups due to regression toward the mean. However, there is no guarantee that bias is entirely eliminated even in a prospective study with double blinding.

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Authors
  1. P. Schnuelle
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  2. F. J. van der Woude
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Editors and Affiliations

  1. Harvard Medical School, Boston, MA, USA

    Mohamed H. Sayegh

  2. Mario Negri Institute for Pharmacological Research, Bergamo, Italy

    Giuseppe Remuzzi

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© 2001 Kluwer Academic Publishers

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Schnuelle, P., van der Woude, F.J. (2001). Clinical Trials in Transplant Immunosuppression: What Have We Learned?. In: Sayegh, M.H., Remuzzi, G. (eds) Current and Future Immunosuppressive Therapies Following Transplantation. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-1005-4_2

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  • DOI: https://doi.org/10.1007/978-94-010-1005-4_2

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-3876-8

  • Online ISBN: 978-94-010-1005-4

  • eBook Packages: Springer Book Archive

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