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Clinical Trials in Transplant Immunosuppression: What Have We Learned?

  • P. Schnuelle
  • F. J. van der Woude

Abstract

Evidence-based medicine relies on clinical trials, which are mandatory prior to the introduction of novel therapeutic strategies into clinical practice. The experimental design most appropriate for the comparison of therapeutic intervention is the randomized controlled clinical trial. These trials are designed to assess the efficacy of treatment in quantitative terms which are frequency of defined events (primary end-points) and time course of disease. Randomization minimizes selection bias and prevents bias in the comparison between study groups due to regression toward the mean. However, there is no guarantee that bias is entirely eliminated even in a prospective study with double blinding.

Keywords

Acute Rejection Graft Survival Renal Transplant Recipient Renal Allograft Mycophenolate Mofetil 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic Publishers 2001

Authors and Affiliations

  • P. Schnuelle
  • F. J. van der Woude

There are no affiliations available

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