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Assessment and Management of Environmental Risks pp 363–371Cite as

The Usage of Biomarkers in Some Environmental and Occupational Chemical Exposure Cases in Turkey

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Part of the book series: NATO Science Series ((NAIV,volume 4))

Abstract

One of the important tools to protect human health from harmful chemicals in the environment or the workplace is the risk assessment. The exposure assessment is one of the four major areas of the risk assessment (the others are hazard identification, dose-response assessment and risk characterization). Reliable and sensitive biomarkers are important tools for exposure assessment.

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References

  1. Anonymous (1997) Application of biomarkers in cancer epidemiology-workshop report, in P. Toniolo, P. Boffetta, D.E.G. Shuker, N. Rothman, B. Hulka and N. Pearce, (eds.), Application of Biomarkers in Cancer Epidemiology, IARC Scientific Publication, No.142, Lyon, pp.1–18.

    Google Scholar 

  2. Ward, J.B. and Henderson, R.E. (1996) Identification of needs in biomarker research, Environ. Health Perspect. 104, 895–900.

    Google Scholar 

  3. Fischman, M.L., Cadman, E.C. and Desmond, S (1990) Occupational Cancer, in J. LaDou (eds.) Occupational Medicine, Prentice-Hall, Connecticut, pp. 182–208.

    Google Scholar 

  4. Perera (1993) Biomarkers and molecular epidemiology of occupational related cancer, J Toxicol. Environ. Health 40, 203–215.

    Article  CAS  Google Scholar 

  5. Perera, F. and Whyatt, R. M. (1994) Biomarkers and molecular epidemiology in mutation/cancer research, Mutation Res. 313, 117–129.

    CAS  Google Scholar 

  6. DeRosa, C.T., Stevens, Y.W., Wilson, J.W., Ademeyero, A.A., Buchanan, S.D., Cibulas, W., Hughes, P.J., Mumtaz, M.M. Neft, R.E., Pohl, H.R. and Johnson, M. M. (1993) The Agency for Toxic Substances and Disease Registry’s Role in Development and Application of Biomarkers in Public Health Service. Toxicol. Indust. Health 9, 979–994.

    CAS  Google Scholar 

  7. Fennell, T.R.(1990) Biological markers of exposure to chemical carcinogens, CIITActivities 10 (1),1–7.

    Google Scholar 

  8. Karakaya, A., lko, M., Ulusu, T., Akal, N., I mer, A. and Karakaya A.E. (1996) Lead levels in deciduous teeth of children from urban and suburban regions in Ankara (Turkey), Bull. Environ. Contain. Toxicol. 56, 16–20.

    Article  CAS  Google Scholar 

  9. Karakaya, A., Süzen, S. and Yücesoy, B. (1992) A biological monitoring method for cadmium, J. Anal. Toxicol. 16, 403.

    CAS  Google Scholar 

  10. Winneke, G., Kramer, U., Brockhaus, A., Ewers, U., Kujanek, G., Lechner, H. and Janke, W. (1983) Neuropsycological studies in children with elevated tooth-lead concentrations, Int. Arch. Occup. Environ. Health 51, 231–252.

    Article  CAS  Google Scholar 

  11. Pocock, S.J., Ashby. D. and Smith, M.A. LaDou (eds.) (1987) Lead exposure and children’s intellectual performance, Int. J. Epidemiol. 16, 57–67.

    Article  CAS  Google Scholar 

  12. Brockhaus, A., Collet, W., Dolgner, R., Engelke, R., Ewers, U., Freier, I., Jermann. E., Kramer, U., Manojlovic, N., Turfeld, M. and Winneke, G. (1988) Exposure to lead and cadmium of children living in different areas of North-West Germany: results of biological monitoring studies 1982–1986, Int. Arch. Occup. Environ. Health 60, 211–222.

    Article  CAS  Google Scholar 

  13. Bergomi, M., Borella, P., Fantuzzi, G., Vivoli, G., Sturloni, N., Cavazzuti, G., Tampieri, A. and Tartoni, P.L. (1989) Relationship between lead exposure indicators and neuropsycological performance in children, Dev. Med. Child Neurol. 31, 181–190.

    Article  CAS  Google Scholar 

  14. Rabinowitz, M.B., Leviton, A. and Bellinger, D.C. (1989) Blood lead-tooth lead relationship among Boston children, Bull. Environ. Contam. Toxicol. 43, 485–492.

    Article  CAS  Google Scholar 

  15. McMichael A.J, Baghurst P.A, Vimpani G.V, Wigg N.R, Robertson E.F. and Tong S. (1994) Tooth lead levels and IQ in school-age children: The Port Pirie cohort study, Am. J. Epidemiol. 140, 489–499.

    CAS  Google Scholar 

  16. Gil, F., Pérez, M.L, Facio, A, Villanueva, E, Tojo, R. and Gil, A. (1994) Dental lead levels in the Galician population, Spain, Sci. Total Environ. 156, 145–150.

    Article  CAS  Google Scholar 

  17. Al-Mahroos, F. and Al-Saleh, F.S. (1997) Lead levels in deciduous teeth of children in Bahrain, Ann. Trop. Paediatr. 17, 147–154.

    CAS  Google Scholar 

  18. Tvinnereim, H.M., Eide, R, Ruse, T., Wesenberg, G.R, Fosse, G. and Steinnes, E. (1997) Lead in primary teeth from Norway: changes in lead levels from the 1970s to the 1990s, Sci. Total Environ. 207,165–177.

    Article  CAS  Google Scholar 

  19. Finkelman, J. (1996) Phasing out leaded gasoline will not end leaded poisoning in developing countries (editorial), Environ. Health Perspect. 104, 10–11.

    Article  CAS  Google Scholar 

  20. Harris, C.A., Hagan, S.O. and Merson, G.H.J. (1999) Organochlorine compound residues in human milk in the United Kingdom 1997–8, Human. Exp. Toxicol. 18, 602–606.

    Article  CAS  Google Scholar 

  21. Karakaya, A.E. and Özalp, S. (1987) Organochlorine pesticides in human adipose tissue collected in Ankara (Turkey) 1984–1985, Bull. Environ. Contam. Toxicol. 38, 941–945.

    Article  CAS  Google Scholar 

  22. Karakaya, A.E., Burgaz, S. and Kanz k, I. (1987) Organochlorine pesticide contaminants in human milk from different regions of Turkey, Bull. Environ. Contain. Toxicol. 39, 506–510.

    Article  CAS  Google Scholar 

  23. Burgaz, S., Afkham, B.L. and Karakaya, A.E. (1994) Organochlorine pesticide contaminants in human adipose tissue collected in Ankara (Turkey) 1991–1992, Bull. Environ. Contam. Toxicol. 53, 501–508.

    Article  CAS  Google Scholar 

  24. Çok, I., Bilgili, A., Özdemir, M., Özbek, H., Bilgili, N. and Burgaz, S. (1997) Organochlorine pesticide residues in human breast milk from agricultural regions of Turkey 1995–1996, Bull. Environ. Contain. Toxicol. 59, 577–582.

    Article  Google Scholar 

  25. Çok, I., Bilgili A., Yarsan E., Bagc, C. and Burgaz, S. (1998) Organochlorine pesticide residue levels in human adipose tissue of residences of Manisa (Turkey), Bull. Environ. Contam. Toxicol. 61, 311–316.

    Article  Google Scholar 

  26. Burgaz, S., Afkham, B.L. and Karakaya, A.E. (1995) Organochlorine pesticide contaminants in human adipose tissue collected in Tebriz (Iran), Bull. Environ. Contam. Toxicol. 54, 546–553.

    Article  CAS  Google Scholar 

  27. Gomez-Catalan, J., Planas, J., To-Figureas, J., Camps, M. and Corbella, J (1993) Organochlorine pesticide residues in the population of Catalonia (Spain), Bull. Environ. Contam.Toxicol. 51, 160–164.

    Article  CAS  Google Scholar 

  28. Gomez-Catalan, J., Lezaun, M., To-Figureas, J. and Corbella, J (1995) Organochlorine residues in the adipose tissue of the population of Navarra (Spain), Bull. Environ. Contam. Toxicol. 54, 534–540.

    Article  CAS  Google Scholar 

  29. Ludwicki, J.K. and Goralczyk, K. (1994) Organochlorine pesticides and PCBs in human adipose tissues in Poland, Bull. Environ. Contam. Toxicol. 52, 400–403.

    Article  CAS  Google Scholar 

  30. Tuefel, M., Niessen, K.H., Sartoris, J., Brands, W., Lochbühler, H., Waag K., Schweizer, P. and Oelsnitz, G. (1990) Chlorinated hydrocarbons in fat tissue: analysis of residues in healty children, tumor patients and malformed children, Arch. Environ. Contam. Toxicol. 19, 646–652.

    Article  Google Scholar 

  31. Stellman, S.D., Djordjevic, M.V., Muscat, J.E., Gong L., Bernstein, D., Citron, ML., White, A., Kemeny, M., Busch, E. and Nafziger, N. (1998) Relative abundance of organochlorine pesticides and polychlorinated biphenyls in adipose tissue and serum of women in Long Island, New York. Cancer Epidemiol. Biomarkers Prey. 7, 489–496.

    CAS  Google Scholar 

  32. Waliswewski, SM., Pardio, V.T.S., Chantiri, J.N.P., Infanzon R.M.R. and Rivera, J. (1996) Organochlorine pesticide residues in adipose tissue of Mexicans, Sci. Total Environ. 181, 125–131.

    Article  Google Scholar 

  33. Kanja, L.W., Skaare, J.V., Ojwang, S.B. and Maitai, C.K. (1992) A comparison of organochlorine pesticide residues in maternal adipose tissue, maternal blood, cord blood, and human milk from mother/infant pairs, Arch. Environ. Contam. Toxicol. 22, 21–24.

    Article  CAS  Google Scholar 

  34. Çok, I., Karakaya, A.E., Afkham, B.L. and Burgaz, S. (1999) Organochlorine Pesticide Contaminants in human milk samples collected in Tebriz (Iran), Bull. Environ. Contam.Toxicol. 63, 444–450.

    Article  Google Scholar 

  35. Saleh, M., Kamel, A., Ragab, A., El-Baroty, G. and El-Sabae, A. (1996) Regional distribution of organochlorine insecticide residues in human milk from Egypt, J. Environ. Sci. Health. 31, 241–255.

    Article  CAS  Google Scholar 

  36. Hernandez, L.M., Fernandez, M.A., Hoyas, E., Gonzalez, M.J. and Garcia, J.F (1993) Organochlorine insecticide and polychlorinated biphenyl residues in human breast milk in Madrid (Spain), Bull. Environ. Contam. Toxicol. 50, 308–315.

    CAS  Google Scholar 

  37. Czaja, K., Ludwicki, K., Goralczyk, K. and Strucinski, P. (1997) Effect of age and number of deliveries on mean concentration of organochlorine compounds in human breast milk in Poland, Bull. Environ. Contam.Toxicol. 59, 407–413.

    Article  CAS  Google Scholar 

  38. Bordet, F., Mallet, J., Maurice, L., Borrel, S. and Venant, A. (1993) Organochlorine pesticide and PCB congener content of French human milk, Bull. Environ. Contam.Toxicol. 53, 425–432.

    Google Scholar 

  39. Gladen, B.C., Monaghan, S.C., Lukyanova, E.M., Hulchiy, O.P., Shkyryak-Nyzhnyk, Z.A., Sericano, J.L. and Little, R.E (1999) Organochlorines in breast milk from two cities in Ukraine, Environ. Health Perspect. 107, 459–462.

    Article  CAS  Google Scholar 

  40. Waliswewski, S.M., Pardio, V.T.S., Chantiri, J.N.P., Infanzon R.M.R. and Rivera, J. (1996) Organochlorine pesticide residues in human breast milk from tropical areas in Mexico, Bull. Environ. Contam. Toxicol. 57, 22–28.

    Article  Google Scholar 

  41. Ejobi, F., Kanja, L.W., Kyule, M.N., Müller, P., Krüger, J. and Latigo, A.A.R (1996) Organochlorine pesticide residues in mothers’ milk in Uganda, Bull. Environ. Contam.Toxicol. 56, 873–880.

    Article  CAS  Google Scholar 

  42. Burgaz, S., Borm, P.J.A. and Jongeneelen, F.J. (1992) Evaluation of urinary excretion of 1hydroxypyrene and thioethers in workers exposed to bitumen fumes, Int. Arch. Occup. Environ. Health 63,397–401.

    Article  CAS  Google Scholar 

  43. Karahalil, B., Karakaya, A.E. Fi ek, G. and Burgaz, S. (1998) Biological monitoring of young workers exposed to polycyclic aromatic hydrocarbons in engine repair workshops, Mutation Res. 412, 261–269.

    CAS  Google Scholar 

  44. Karakaya, A.E.,.Karahalil, B., Y lmazer, M., Aygün, N., arda, S. and Burgaz, S. (1997) Evaluation of genotoxic potential of styrene in furniture workers using unsaturated polyester resins, Mutation Res. 392, 261–268.

    CAS  Google Scholar 

  45. Burgaz, S., Cok,., Ulusoy, L., Tarhan, U., Aygün, N. and Karakaya, A.E. (1997) Biological monitoring of n-hexane exposure in shoe workers, Biomarkers 2, 25–28.

    Google Scholar 

  46. Bayhan, A., Burgaz, S. and Karakaya, A.E. (1987) Urinary thioether excretion in nurses at an oncologie department, J. Clin. Pharm. Therap. 12, 303–306.

    Article  CAS  Google Scholar 

  47. Burgaz, S., Rezanko, R., Kara., S. and Karakaya, A.E. (1992) Thioethers in urine of sterilization personnel exposed to ethylene oxide, J. Clin Pharm. Therap. 17,169–172.

    CAS  Google Scholar 

  48. ILO (International Labour Office) (1988) Occupational Cancer: Prevention and Control, Occupational Safety and Health Series No. 39, Geneva.

    Google Scholar 

  49. Burgaz, S., Erdem, O., Karahalil, B. and Karakaya, A.E. (1998) Evaluation of genotoxic damage in peripheral lymphocytes of road paving workers exposed to bitumen fumes, Mutation Res. 419, 123–130.

    CAS  Google Scholar 

  50. arda, S., Karakaya, A.E. and Furtun, Y. (1994) Sister chromatid exchanges in workers employed in car painting workshops, Int. Arch. Occup. Environ. Health 66, 33–35

    Article  Google Scholar 

  51. arda, S., Aygün, N. and Karakaya, A.E. (1997) Genotoxicity studies on professional hair colorists exposed to oxidation hair dyes, Mutation Res. 394, 153–161.

    Google Scholar 

  52. arda, S., Gök, S. and Karakaya, A.E.(1991) Sister chromatid exchanges in lymphocytes of nurses handling antineoplastic drugs, Toxicol. Lett. 55, 331–335.

    Google Scholar 

  53. Burgaz, S., Karahalil, B., Bayrak, P., Ta k n, L., Yavuzaslan, F., Bökesoy, I., Anzion, R.B.M., Bos, R.P. and Platin, N. (1999)Urinary cyclophosphamide excretion and micronuclei frequencies in peripheral lymphocytes and exfoliated buccal epithelial cells of nurses handling antineoplastics, Mutation Res. 439, 97–104.

    CAS  Google Scholar 

  54. arda, S., Cuhruk, H., Karakaya, A.E. and Atakurt, Y. (1992) Sister chromatid exchanges in operating room personnel, Mutation Res. 279, 117–120.

    Article  Google Scholar 

  55. arda, S., Aygün, N., Gaml, M., final, Y., final, N., Berk, N. and Karakaya, A.E. (1998) Use of alkaline Comet Assay (single cell electrophoresis technique) to detect DNA damage in lymphocytes of operating room personnel occupationally exposed to anaesthetic gases. Mutation Res. 418, 93–100.

    Google Scholar 

  56. Karahalil, B., Karakaya, A.E. and Burgaz, S. (1999) The micronucleus assay in exfoliated buccal cells: application to occupational exposure to polycyclic aromatic hydrocarbons, Mutation Res. 442, 29–35.

    CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Toxicology, Faculty of Pharmacy Gazi Univesity, Ankara, 06330, Turkey

    A. E. Karakaya

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  1. A. E. Karakaya
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Editors and Affiliations

  1. Arthur D. Little, Inc., Cambridge, Massachusetts, USA

    Igor Linkov

  2. Menzie-Cura & Associates, Inc., USA

    Igor Linkov

  3. University of Lisbon, Portugal

    Jose Palma-Oliveira

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© 2001 Kluwer Academic Publishers

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Karakaya, A.E. (2001). The Usage of Biomarkers in Some Environmental and Occupational Chemical Exposure Cases in Turkey. In: Linkov, I., Palma-Oliveira, J. (eds) Assessment and Management of Environmental Risks. NATO Science Series, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0987-4_38

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  • DOI: https://doi.org/10.1007/978-94-010-0987-4_38

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-1-4020-0024-9

  • Online ISBN: 978-94-010-0987-4

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