Abstract
We studied the association between long-term outdoor air pollution and myocardial infarction risk. We conducted a case-control study among 25-64 year old men in a general population of Kaunas city. Cases were 404 patients with first myocardial infarction, treated in Kaunas hospitals over two years and controls were 1,068 randomly selected men without ischemic heart disease. The analysis involved incidence analysis, questionnaire information on myocardial infarction risk factors, and multivariate logistic regression models. The comparison of age-adjusted myocardial infarction incidence in areas with different NO2exposure revealed that incidence increased with increasing NO2pollution levels, χ2for trend was 4.44, p=0.035. Population attributable risk was 7.1 percent. The risk ratio in the medium exposure area compared to the low exposure area was 1.20, 95% CI 0.98-1.47, while in the high exposure area it was 1.37, 95% 0.91-2.07. We observed increased population attributable risk in 55-64 year old men. Adjustment for age, smoking, blood pressure, stress and sexual disorders reduced excess risk for NO2to insignificant meaning, OR=1.11, 95%CI 0.84-1.46. Study results indicated that outdoor NO2exposure below current guidelines might increase myocardial infarction risk.
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Grazuleviciene, R., Jakucionyte, L., Malinauskiene, V. (2001). Assessment of Environmental No2Exposure Effect on First Myocardial Infarction Risk in Kaunas, Lithuania. In: Linkov, I., Palma-Oliveira, J. (eds) Assessment and Management of Environmental Risks. NATO Science Series, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0987-4_36
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DOI: https://doi.org/10.1007/978-94-010-0987-4_36
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