Uncovering the Differences between T Cell Tolerance and Immunity

  • Anthony T. Vella


In the last two decades, T cell function has been analyzed in vitro from many different angles, with a great deal of attention dedicated to the basic requirements of activation. During this time, a compendium of information has been collected and has proven to be invaluable. Paradoxically, very little is known about T cell activation and function in vivo. In the last decade, a number of models have been developed which allow the tracking of Ag-activated T cells in vivo and these studies have been instrumental in advancing the field of T cell biology. In particular, a new and emerging paradigm of T cell immunity is evolving.

Key words

T cell activation immunity immune memory 


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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Anthony T. Vella
    • 1
  1. 1.Department of MicrobiologyOregon State UniversityCorvallisUSA

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