Abstract
Biocatalysis and its applications to synthesis has risen to prominence in recent years in both academic and industrial domains Several recent reviews highlight the applications of enzymes to the production of enantiomerically pure synthons for manufacturing of fine chemicals.[1-5] Various lipases are now commonly used in organic synthesis for desymmetrization of meso compounds. On the other hand, oxidoreductases have not been used so extensively in organic synthesis because there are difficulties in handling such enzymes as isolated entities and due to the necessity of recycling cofactors. For this reason, whole-cell fermentation is the method of choice in the application of oxidoreductases to organic synthesis. Both bacterial cells (E. coli recombinant organisms) and yeast are now used for such reactions as epoxidation, diol formation, and Baeyer-Villiger oxidation.
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Hudlicky, T. (2000). Biocatalytic Synthesis of Alkaloids and Carbohydrates: An Update. In: Zwanenburg, B., Mikołajczyk, M., Kiełbasiński, P. (eds) Enzymes in Action. NATO Science Partnership Sub-Series: 1:, vol 33. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0924-9_16
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DOI: https://doi.org/10.1007/978-94-010-0924-9_16
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