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Clinical Value of Viable Myocardium Detection

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Book cover Myocardium at Risk and Viable Myocardium

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 234))

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Abstract

Myocardial viability is highly topical as evidenced by numerous editorials that have been published in the high-impact cardiology journals [1-9]. The most relevant aspects of viable myocardium from the point of view of clinical practice are:

  1. 1

    In which patients are these diagnoses of myocardial viability to be conducted

  2. 2

    Which methods need to be employed for the diagnoses

  3. 3

    Do these diagnoses have prognostic implications for the patient’s therapeutic management

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References

  1. Rahimtoola SH. Hibernating myocardium has reduced blood flow at rest that increases with low-dose dobutamine. Circulation 1996; 94: 3055–3061.

    Article  CAS  PubMed  Google Scholar 

  2. Iskandrian AS. Myocardial viability: Unresolved issues. J Nucl Med 1996; 37: 794–797.

    CAS  PubMed  Google Scholar 

  3. Kaul S. Response of dysfunctional myocardium to dobutamine. The eyes see what the mind knows!“. J Am Coll Cardiol 1996; 27: 1608–1611.

    Article  CAS  PubMed  Google Scholar 

  4. Wackers FJT. Radionuclide detection of myocardial ischemia and myocardial viability: Is the glass half empty or half full?. J Am Coll Cardiol 1996; 27: 1598–1600.

    Article  CAS  PubMed  Google Scholar 

  5. Dilsizian V. Myocardial viability: Contractile reserve or cell membrane integrity. J Am Coll Cardiol 1996; 28: 443–446.

    Article  CAS  PubMed  Google Scholar 

  6. Beller GA. Comparison of 201Tl scintigraphy and low-dose dobutamine echocardiography for the noninvasive assessment of myocardial viability. Circulation 1996; 94: 2681–2684.

    Article  CAS  PubMed  Google Scholar 

  7. McGhie AI, Weyman A. Searching for hibernating myocardium. Time to reevaluate investigative strategies?. Circulation 1996; 94: 2685–2688.

    Article  CAS  PubMed  Google Scholar 

  8. Armstrong WF. “Hibernating” myocardium: Asleep or part dead?. J Am Coll Cardiol 1996; 28: 530–535.

    Article  CAS  PubMed  Google Scholar 

  9. Vanoverschelde JLJ, Wijns W, Borgers M et al. Chronic myocardial hibernation in humans. From bedside to bench. Circulation 1997; 95: 1961–1971.

    Article  CAS  PubMed  Google Scholar 

  10. Lewis SJ, Sawada SG, Ryan T, Segar DS, Armstrong WF, Feigenbaum H. Segmental wall motion abnormalities in the absence of clinically documented myocardial infarction: Clinical significance and evidence of hibernating myocardium. Am Heart J 1991; 121: 1088–1093.

    Article  CAS  PubMed  Google Scholar 

  11. Candell-Riera J, Santana-Boado C, Castell-Conesa J, et al. Simultaneous dipyridamole/maximal subjective exercise with 99mTc-MIBI SPECT: improved diagnostic yield in coronary arterty disease. J Am Coll Cardiol 1997; 29: 531–536.

    Article  CAS  PubMed  Google Scholar 

  12. Lemlek J, Heo J, Iskandrian AS. The clinical relevance of myocardial viability in patient management. Am Heart J 1992; 124: 1327–1331.

    Article  CAS  PubMed  Google Scholar 

  13. Candell-Riera J, Permanyer-Miralda G, Castel! J et al. Uncomplicated first myocardial infarction: Strategy for comprehensive prognostic studies. J Am Coll Cardiol 1991; 18: 1207–1219.

    Article  CAS  PubMed  Google Scholar 

  14. Olona M, Candell-Riera J, Permanyer-Miralda G et al. Strategies for prognostic assessment of uncomplicated first myocardial infarction: A 5-years follow up study. J Am Coll Cardiol 1995; 25: 815–822.

    Article  CAS  PubMed  Google Scholar 

  15. Santana C, Candell-Riera J, Aguadé S et al. Extensión del territorio no viable en el infarto anterior, inferior y no Q. Estudio con 99mTc-MIBI SPET de reposo. Rev Esp Cardiol 1997; 50 (Supl. 6): 79 (Abstr.).

    Google Scholar 

  16. Candell-Riera J, González JM, Castell J et al. Cuantificación de la extensión de miocardio viable mediante 99mTc-MIBI SPET de reposo. Rev Esp Cardiol 1997; 50 (Supl. 6): 57 (Abstr.).

    Google Scholar 

  17. Margonato A, Ballarotto C, Bonetti F et al. Assessment of residual tissue viability by exercise testing in recent myocardial infarction: Comparison of the electrocardiogram and myocardial perfusion scintigraphy. J Am Coll Cardiol 1992;19: 948–952.

    Article  CAS  PubMed  Google Scholar 

  18. Margonato A, Chierchia SL, Xuereb RG et al. Specificity and sensitivity of exercise-induced ST segment elevation for detection of residual viability: Comparison with fluorodeoxyglucose and positron emission tomography. J Am Coll Cardiol 1995; 25: 1032–1038.

    Article  CAS  PubMed  Google Scholar 

  19. Candell-Riera J, Santana-Boado C, Armadans-Gil L et al. Comparison of patients with anterior wall healed myocardial infarction with and without exercise induced ST segment elevation. Am J Cardiol 1998; 81: 12–16.

    Article  CAS  PubMed  Google Scholar 

  20. Piérard LA, De Landsheere CM, Berthe C, Rigo P, Kulbertus HE. Identification of viable myocardium by echocardiography during dobutamine infusion in patients with myocardial infarction after thrombolytic therapy: comparison with positron emission tomography. J Am Coll Cardiol 1990; 15: 1021–1031.

    Article  PubMed  Google Scholar 

  21. Barilla F, Gheorgiade M, Alam M, Khaja F, Goldstein S. Low-dose dobutamine in patients with acute myocardial infarction identifies viable but not contractile myocardium and predicts the magnitude of improvement in wall motion abnormalities in response to coronary revascularization. Am Heart J 1991; 122: 1522–1531.

    Article  CAS  PubMed  Google Scholar 

  22. Cigarroa CG, deFilippi CR, Brickner ME, Alvarez LG, Wait MA, Grayburn PA. Dobutamine stress echocardiography identifies hibernating myocardium and predicts recovery of left ventricular function after coronary revascularization. Circulation 1993; 88: 430–436.

    Article  CAS  PubMed  Google Scholar 

  23. La Canna G, Alfieri O, Giubbini R, Gargano M, Ferrari R, Visioli O. Echocardiography during infusion of dobutamine for identification of reversible dysfunction in patients with chronic coronary artery disease. J Am Coll Cardiol 1994; 23: 617–626.

    Article  PubMed  Google Scholar 

  24. Afridi I, Kleiman NS, Raizner AE, Zoghbi WA. Dobutamine echocardiography in myocardial hibernation. Optimal dose and accuracy in predicting recovery of ventricular function after coronary angioplasty. Circulation 1995; 91: 663–670.

    Article  CAS  PubMed  Google Scholar 

  25. Perrone-Filardi P, Pace L, Prastaro M et al. Dobutamine echocardiography predicts improvement of hypoperfused dysfunctional myocardium after revascularization in patients with coronary artery disease. Circulation 1995; 91: 2556–2565.

    Article  CAS  PubMed  Google Scholar 

  26. Arnese M, Comel JH, Salustri A et al. Prediction of improvement of regional left ventricular function after surgical revascularization. A comparison of low-dose dobutamine echocardiography with 201TI single-photon emission computed tomography. Circulation 1995; 91: 2748–2752.

    Article  CAS  PubMed  Google Scholar 

  27. De Filippi CR, Willett DL, Irani WN, Eichhorn EJ, Velasco CE, Grayburn PA. Comparison of myocardial contrast echocardiography and low-dose dobutamine stress echocardiography in predicting recovery of left ventricular function after coronary revascularization in chronic ischemic heart disease. Circulation 1995; 92; 92: 2863–2868.

    Article  Google Scholar 

  28. Smart SC, Sawada S, Ryan T et al. Low-dose dobutamine echocardiography detects reversible dysfunction after thrombolytic therapy of acute myocardial infarction. Circulation 1993; 88: 408–415.

    Article  Google Scholar 

  29. Chen C, Chen LL, Prada JV et al. Incremental doses of dobutamine induce a biphasic response in dysfunctional left ventricular regions subtending coronary stenoses. Circulation 1995; 92: 756–766.

    Article  CAS  PubMed  Google Scholar 

  30. Hoffman R, Lethen H, Marwick T et al. Analysis of interinstitutional observer agreement in interpretation of dobutamine stress echocardiogramas. J Am Coll Cardiol 1996; 27: 330–336.

    Article  Google Scholar 

  31. Panza JA, Dilsizian V, Laurienzo JM, Curiel RV, Katsiyiannis PT. Relation between thallium uptake and contractile response to dobutamine. Implications regarding myocardial viability in patients with chronic coronary artery disease and left ventricular dysfunction. Circulation 1995; 91: 990–998

    Article  CAS  PubMed  Google Scholar 

  32. Kaul S, Jayaweera AR, Glasheen WP, Villanueva FS, Gutgesel HP, Spotnitz WD. Myocardial contrast echocardiography and the transmural distribution of flow: a critical apraisal during myocardial ischemia not associated with infarction. J Am Coll Cardiol 1992; 20: 1005–1006.

    Article  CAS  PubMed  Google Scholar 

  33. De la Torre JM, Martin Duran R. Ecocardiografia de contraste. Rev Esp Cardiol 1997; 50 (Supt. 5): 15–25.

    Google Scholar 

  34. Bax JJ, Wijns W, Cornel JH, Visser FC, Boersma E, Fioretti PM. Accuracy of currently available techniques for prediction of functional recovery after revascularization in patients with left ventricular dysfunction due to chronic coronary artery disease: comparison to pooled data. J Am Coll Cardiol 1997; 30: 1451–1460.

    Article  CAS  PubMed  Google Scholar 

  35. Scognamiglio R, Fasoli G, Casarotto D et al. Postextrasystolic potentiation and dobutamine echocardiography in predicting recovery of myocardial function after coronary bypass revascularization. Circulation 1997; 96: 816–820.

    Article  CAS  PubMed  Google Scholar 

  36. Hoffer EP, Dewé W, Celentano C, Piérard LA. Low-level exercise echocardiography detects contractile reserve and predicts reversible dysfunction after acute myocardial infarction. Comparison with low-dose dobutamine echocardiography. J Am Coll Cardiol 1999; 34: 989–997.

    Article  CAS  PubMed  Google Scholar 

  37. Amanullah AM, Chaudhry FA, Heo J et al. Comparison of dobutamine echocardiography, dobutamine sestamibi, and rest-redistribution thallium-201 single-photon emission computed tomography for determining contractile reserve and myocardial ischemia in ischemic cardiomyopathy. Am J Cardiol 1999; 84: 626–631.

    Article  CAS  PubMed  Google Scholar 

  38. Spinelli L, Petretta M, Cuocolo A et al. Prediction of recovery of left ventricular dysfunction after acute myocardial infarction: comparison between 99mTc-sestamibi cardiac tomography and low-dose dobutamine echocardiography. J Nucl Med 1999; 1683–1692.

    Google Scholar 

  39. Panza JA, Dilsizian V, Curiel RV, Unger EF, Laurienzo JM, Kitsiou AN. Myocardial blood flow at rest and contractile reserve in patients with chronic coronary artery disease and left ventricular dysfunction. J Nucl Cardiol 1999; 6: 487–494.

    Article  CAS  PubMed  Google Scholar 

  40. Bax JJ, Poldermans D, Visser FC et al. Delayed recovery of hibernating myocardium after surgical revascularization: implications for discrepancy between metabolic imaging and dobutamine echocardiography for assessment of myocardial viability. J Nucl Cardiol 1999; 6: 685–687.

    Article  CAS  PubMed  Google Scholar 

  41. Everaert H, Vanhove C, Franken PR. Low-dose dobutamine gated single-photon emission tomography: comparison with stress echocardiography. Eur J Nucl Med 2000; 27: 413–418.

    Article  CAS  PubMed  Google Scholar 

  42. Lu C, Canino M, Fragasso G et al. Enoximone echocardiography for predicting recovery of left ventricular dysfunction after revascularization. A novel test for detecting myocardial viability. Circulation 2000; 101: 1255–1260.

    Article  CAS  PubMed  Google Scholar 

  43. Iwakura K, Ito H, Nishikawa N et al. Use of echocardiography for predicting myocardial vviability in patients with reperfused anterior wall infarction Am J Cardiol 2000; 85: 744–748.

    Article  CAS  PubMed  Google Scholar 

  44. Cwajg JM, Cwajg E, Nagueh SF et al. End-diastolic wall thickness as a predictor of recovery of function in myocardial hibernation. Relation to rest-redistribution TI-201 tomography and dobutamine stress echocardiography. J Am Coll Cardiol 2000; 35: 1152–1161.

    Article  CAS  PubMed  Google Scholar 

  45. Rozanski A, Berman D, Gray R et al. Preoperative prediction of reversible myocardial asynergy by postexercise radionuclide ventriculography. N Engl J Med 1982; 307: 212–216.

    Article  CAS  PubMed  Google Scholar 

  46. Borer JS, Bacharach SL, Green MV, Kent KM, Johnston GS, Epstein SE. Effect of nitroglycerin on exercise-induced abnormalities of left ventricular regional function and ejection fraction in coronary artery disease. Assessment by radionuclide cineangiography in symptomatic and asymptomatic patients. Circulation 1978; 57: 314–320.

    Article  CAS  PubMed  Google Scholar 

  47. Ritchie JL, Sorensen SG, Kennedy JW, Hamilton GW. Radionuclide angiography: Noninvasive assessment of hemodynamic changes after administration of nitroglycerin. Am J Cardiol 1979; 43: 278–284.

    Article  CAS  PubMed  Google Scholar 

  48. Satler LF, Kent KM, Fox LM et al. The assessment of contractile reserve after thrombolytic therapy for acute myocardial infarction. Am Heart J 1986; 111; 821–825.

    Article  CAS  PubMed  Google Scholar 

  49. Pérez-Baliño NA, Masoli OH, Meretta AH et al. Amrinone stimulation test: Ability to predict improvement in left ventricular ejection fraction after coronary bypass surgery in patients with poor baseline left ventricular function. J Am Coll Cardiol 1996; 28: 1488–1492.

    Article  PubMed  Google Scholar 

  50. Dove JT, Shah PM, Schreiner BF. Effects of nitroglycerin on left ventricular wall motion in coronary artery disease. Circulation 1974; 49: 682–687.

    Article  CAS  PubMed  Google Scholar 

  51. Fujita M, Yamanishi K, Hirai T et al. Significance of collateral circulation in reversible left ventricular asynergy by nitroglycerin in patients with relatively recent myocardial infarction. Am HeartJ 1990; 120: 521–528.

    Article  CAS  Google Scholar 

  52. Baer FM, Voth E, Schneider CA, Theissen P, Schicha H, Sechtem U. Comparison of low-dose dobutamine-gradient-echo magnetic resonance imaging and positron emission tomography with (18F)fluorodeoxyglucose in patients with chronic coronary artery disease: a functional and morphological approach to the detection of residual myocardial viability. Circulation 1995; 91: 1006–1015.

    Article  CAS  PubMed  Google Scholar 

  53. Yabe T, Mitsunami K, Inubushi T, Kinoshita M. Quantitative measurements of cardiac phosphorus metabolites in coronary artery disease by phosphorus-31 magnetic resonance spectroscopy. Circulation 1995; 92: 15–23.

    Article  CAS  PubMed  Google Scholar 

  54. Baer FM, Theissen P, Crnac J et al. Head to head comparison of dobutamine-transoesophageal echocartdiography and dobutamine-magnetic resonance imaging for the prediction of left ventricular functional recovery in patients with chronic coronary artery disease. Eur Heart J 2000; 21: 981–991.

    Article  CAS  PubMed  Google Scholar 

  55. Sechtem U, Baer FM, Theissen P, Voth E, Schicha H (1998) Assessment of myocardial viability by magnetic resonance techniques, in Higgins CB, Ingwall JS and Pohost GM (eds.), Futura Publishing Company, Inc., Armonk, NY, pp. 267–282.

    Google Scholar 

  56. Haines DE, Beller GA, Watson DD, Kaiser DL, Sayre SL, Gibson RS. Exercise-induced ST segment elevation 2 weeks after uncomplicated myocardial infarction: Contributing factors and prognostic significance. J Am Coll Cardiol 1987; 9: 996–1003.

    Article  CAS  PubMed  Google Scholar 

  57. Gewirtz H, Sullivan M, O’Reilly G, Winter S, Most AS. Role of myocardial ischemia in the genesis of stress-induced S-T segment elevation in previous anterior myocardial infarction. Am J Cardiol 1983; 51: 1289–1293.

    Article  CAS  PubMed  Google Scholar 

  58. Mazzotta G, Camerini A, Scopinaro G et al. Predicting cardiac mortality after uncomplicated myocardial infarction by exercise radionuclide ventriculography and exercise-induced ST segment elevation. Eur Heart J 1992; 13: 330–337.

    CAS  PubMed  Google Scholar 

  59. Weiner DA, McCabe C, Klein MD, Ryan TJ. ST segment changes post-infarction: Predictive value for multivessel coronary disease and left ventricular aneurysm. J Am Coll Cardiol 1987; 9: 996–1003.

    Article  Google Scholar 

  60. Cahine RA, Raizner AE, Ishimori T. The clinical significance of exercise-induced ST-segment elevation. Circulation 1976; 54: 209–213.

    Article  Google Scholar 

  61. Coma-Canella I, del Val Gómez M, Terol I, Rodrigo F, Castro JM. Radionuclide studies in patients with stress-induced ST-segment elevation after acute myocardial infarction. J Am Coll Cardiol 1994; 128: 459–465.

    CAS  Google Scholar 

  62. Elhendy A, Geleijnse ML, Roelandt JRTC et al. Evaluation by quantitative 99m-technetium MIBI SPECT and echocardiography of myocardial perfusion and wall motion abnormalities in patients with dobutamine-induced ST-segment elevation. Am J Cardiol 1995; 76: 441–448.

    Article  CAS  PubMed  Google Scholar 

  63. Cinca J, Bardají A, Carreño A et al. ST elevation at the surface of a healed transmural myocardial infarction in pigs. Conditions for passive transmission from the ischemic peri-infarction zone. Circulation 1995; 91: 1552–1559.

    Article  CAS  PubMed  Google Scholar 

  64. Kron IL, Flanagan TL, Blackbourne LH et al. Coronary revascularization rather than cardiac transplantation for chronic ischemic cardiomyopathy. Ann Surg 1989; 210: 348–352.

    Article  CAS  PubMed  Google Scholar 

  65. Louie HW, Laks H, Milgalter E et al. Ischemic cardiomyopathy. Criteria for coronary revascularization and cardiac transplantation. Circulation, suppl. III 1991; 84: 290–295.

    Google Scholar 

  66. Luciani GB, Faggian G, Razzolini R et al. Severe ischemic left ventricular failure. Coronary operation or heart transplantation? Ann Thorac Surg 1993; 55: 719–723.

    Article  CAS  PubMed  Google Scholar 

  67. Van Trigt P. Ischemic cardiomyopathy. The role of coronary artery bypass. Coron Artery Dis 1993; 4: 707–712.

    Article  PubMed  Google Scholar 

  68. Elefteriades JA, Tolis G, Jr, Levi E et al. Coronary artery bypass grafting in severe left ventricular dysfunction. Excellent survival with improved ejection fraction and functional state. J Am Coll Cardiol 1993; 22: 1411–1117.

    Article  CAS  PubMed  Google Scholar 

  69. Lansman SL, Cohen M, Galla JD et al. Coronary bypass wih ejection fraction of 0.20 or less using centigrade cardioplegia. Long-term follow-up. Ann Thorac Surg 1993; 56: 480–485.

    Article  CAS  PubMed  Google Scholar 

  70. Milano CA, White WD, Smith LR et al. Coronary artery bypass in patients with severely depressed ventricular function. Ann Thorac Surg 1993; 56: 487–493.

    Article  CAS  PubMed  Google Scholar 

  71. Olsen P, Kassis E, Niebuhr-Jorgensen U. Coronary artery bypass surgery in patients with severe left ventricular dysfunction. Thorac Cardiovasc Surg 1993; 41: 118–120.

    Article  CAS  PubMed  Google Scholar 

  72. Hausmann H, Ennker J, Topp H et al. Coronary artery bypass grafting and heart transplantation in end-stage coronary artery disease. A comparison of hemodynamic improvement and ventricular function. J Card Surg 1994; 9: 77–84.

    Article  CAS  PubMed  Google Scholar 

  73. Ghods M, Pancholy S, Cave V, Cassell D, Heo J, Iskandrian AS. Serial changes in left ventricular function after coronary artery bypass: implications in viability assessment. Am Heart J 1995; 129: 20–23.

    Article  CAS  PubMed  Google Scholar 

  74. Louie HW, Laks H, Milgalter E et al. Ischemic cardiomyopathy: criteria for coronary revascularization and cardiac transplantation. Circulation 1991; 84 (Supt 5): 290–295.

    Google Scholar 

  75. Blitz A, Laks H. The role of coronary revascularization in the management of heart failure: identification of candidates and review of results. Curr Opin Cardiol 1996; 11: 276–290.

    Article  CAS  PubMed  Google Scholar 

  76. Castell J, Candell-Riera J, Roselló-Urgell J et al. Valoración de la viabilidad mίocárdica mediante tecnecio-99m isonitrilo y talio-201. Resultados del protocolo multicéntrico español. Rev Esp Cardiol 1997; 50: 320–330.

    Google Scholar 

  77. Candell-Riera J. 99mTc-MIBI SPET de reposo y esfuerzo-reposo en el diagnóstico de la hibernación miocárdica. Estudio multicéntrico español. Rev Esp Cardiol 1997; 50 (Supl. 6): 57.

    Google Scholar 

  78. Candell Riera J, CastelI Conesa J, González González J, Rosselló J. Grupo de trabajo de Cardiología Nuclear. Eficacia de la tomogammagrafia miocárdica con 99mTc-MIBI en la predicción de la recuperabilidad de la función contráctil post-revascularización. Resultados del protocolo multicéntrico español. Rev Esp Cardiol 2000; 53: 903–910.

    Article  CAS  PubMed  Google Scholar 

  79. Christian TF, Miller TD, Hodge DO, Orszulak TA, Gibbons RJ. An estimate of the prevalence of reversible left ventricular dysfunction in patients referred for coronary artery bypass surgery. J Nucl Cardiol 1997; 4: 140–146.

    Article  CAS  PubMed  Google Scholar 

  80. Tamaki N, Kawamoto M, Tadamura E et al. Prediction of reversible ischemia after revascularization. Perfusion and metabolic studies w2ith positron emission tomography. Circulation 1995; 91: 1697–1705.

    Article  CAS  PubMed  Google Scholar 

  81. Borges-Neto S, Shaw LJ, Kesler K et al. Usefulness of serial radionuclide angiography in predicting cardiac death after coronary artery bypass grafting and comparison with clinical and cardiac catheterization data. Am J Cardiol 1997; 79: 851–855.

    Article  CAS  PubMed  Google Scholar 

  82. Sicari R, Picano E, Landi P et al. Prognostic value of dobutamine-atropine stress echocardiography early after acute myocardial infarction. J Am Coll Cardiol 1997; 29: 254–260.

    Article  CAS  PubMed  Google Scholar 

  83. Eitzman D, Al-Aouar Z, Kanter HL et al. Clinical outcome of patients with advanced coronary artery disease after viability studies with positron emission tomography. J Am Coll Cardiol 1992; 20: 559–565.

    Article  CAS  PubMed  Google Scholar 

  84. Yoshida K, Gould KL. Quantitative relation of myocardial infarct size and myocardial viability by positron emission tomography to left ventricular ejection fraction and 3-year mortality with and without revascularization. J Am Coll Cardiol 1993; 22: 984–997.

    Article  CAS  PubMed  Google Scholar 

  85. Di Carli MF, Davidson M, Little R et al. Value of metabolic imaging with positron emission tomography for evaluating prognosis in patients with coronary artery disease and left ventricular dysfunction. Am J Cardiol 1994; 73: 527–533.

    Article  PubMed  Google Scholar 

  86. Paolini G, Lucignani G, Zuccari M et al. Identification and revascularization of hibernating myocardium in angina free patients with left ventricular dysfunction. Eur J Cardiothorac Surg 1994; 8: 139–144.

    Article  CAS  PubMed  Google Scholar 

  87. Lee KS, Marwick TH, Cook SA et al. Prognosis of patients with left ventricular dysfunction, with and without viable myocardium after myocardial infarction. Relative efficacy of medical therapy and revascularization. Circulation 1994; 90: 2687–2694.

    Article  CAS  PubMed  Google Scholar 

  88. Gioia G, Powwers J, Heo J, Iskandrian AS. Prognostic value of rest-redistribution tomographic thallium-201 imaging in ischemic cardiomyopathy. Am J Cardiol 1995; 75: 759–762.

    Article  CAS  PubMed  Google Scholar 

  89. Pasquet A, Robert A, D’Hondt AM et al. Prognostic value of myocardial ischemia and viability in patients with chronic left ventricular ischemic dysfunction. Circulation 1999; 100: 141–148.

    Article  CAS  PubMed  Google Scholar 

  90. Samady H, Elefteriades JA, Abbott BG, Mattera JA, McPherson CA, Wackers FJT. Failure to improve left ventricular function after coronary revascularization for ischemic cardiomyopathy is not associated with worse outcome. Circulation 1999; 100: 1298–1304.

    Article  CAS  PubMed  Google Scholar 

  91. Sharir T, Berman DS, Lewin HC et al. Incremental prognostic value of rest-redistribution 201TI single-photon emission tomography. Circulation 1999; 100: 1964–1970.

    Article  CAS  PubMed  Google Scholar 

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Soler-Soler, J., Candell-Riera, J. (2001). Clinical Value of Viable Myocardium Detection. In: Candell-Riera, J., Castell-Conesa, J., Aguadé-Bruix, S. (eds) Myocardium at Risk and Viable Myocardium. Developments in Cardiovascular Medicine, vol 234. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0906-5_10

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