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Pathophysiology of Schizophrenia

Neurodevelopmental and Neurodegenerative Processes

  • Chapter
Book cover Early Intervention in Psychotic Disorders

Part of the book series: NATO Science Series ((ASID,volume 91))

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Abstract

Epidemiological and genetic studies have provided important clues that guide the study of the neurobiological basis and the cause of schizophrenia. Studies have revealed that schizophrenia is heterogeneous in phenomenology [1 2], age of onset [3], response to treatment [4] and outcome [5–[7] and illness course [8]. Consequently, etiological or pathophysiological theories of schizophrenia must account for this heterogeneity. One explanation is that schizophrenia may arise from multiple etiological and pathophysiological processes; prompting references to “the schizophrenias” rather than “schizophrenia”. Alternatively, this heterogeneity may be due to a common etiological process, and the variable disease expression due to neurobiological differences that act as modifying factors in affected individuals, or to altered disease expression due to environmental factors.

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Authors and Affiliations

  1. Department of Psychiatry, University of North Carolina at Chapel Hill, CB # 7160, Chapel Hill, North Carolina, 27599-7160

    John Kraus MD, Diana O. Perkins MD, MPH & Jeffrey A. Lieberman MD

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  1. John Kraus MD
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  2. Diana O. Perkins MD, MPH
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  3. Jeffrey A. Lieberman MD
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Editors and Affiliations

  1. Department of Psychiatry, Yale University, New Haven, CT, USA

    Tandy Miller  & Thomas H. McGlashan  & 

  2. Social Science Research Institute, University of California, Los Angeles, CA, USA

    Sarnoff A. Mednick

  3. Psychiatric Center Prague, Prague, Czech Republic

    Jan Libiger

  4. Rogaland Psychiatric Hospital, Stavanger, Norway

    Jan Olav Johannessen

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Kraus, J., Perkins, D.O., Lieberman, J.A. (2001). Pathophysiology of Schizophrenia. In: Miller, T., Mednick, S.A., McGlashan, T.H., Libiger, J., Johannessen, J.O. (eds) Early Intervention in Psychotic Disorders. NATO Science Series, vol 91. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0892-1_12

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  • DOI: https://doi.org/10.1007/978-94-010-0892-1_12

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-0-7923-6750-5

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