What can we learn about the principles of motor control by looking at the nervous system? There are few examples of movements for which the neural control is known extensively. Those for which the neural substrate is perhaps best understood are stereotypic rhythmic movements such as breathing and locomotion. For many of these movements there exists a neural network which can produce a motor output having many of the temporal characteristics of the movement. Such networks, called (CPGs), can often function in the complete absence of either sensory feedback or descending control (Delcomyn 1980). However, in all cases, sensory inputs and descending control contribute significantly and can entrain and modulate the basic rhythm.


Spinal Cord Muscle Synergy Couple Nonlinear Oscillator Motor Synergy Fictive Locomotion 
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  1. Altaian, J.S., & J. Kien (1986). A model for decision making in the insect nervous system. In M.A. Ali (ed.), Nervous systems in invertebrates (pp. 621–643). New York: Plenum Press.Google Scholar
  2. Bayev, K.V., & P.G. Kostyuk (1982). Polarization of primary afferent terminals of lumbosacral cord elicited by the activity of spinal locomotor generator. Neuroscience 7, 1401–1409.CrossRefGoogle Scholar
  3. Cohen, A.H., L. Guan, J. Harris, R. Jung, & T. Kiemel (1996). Interaction between the caudal brainstem and the lamprey central pattern generator for locomotion. Neuroscience 74, 1161–1173.Google Scholar
  4. Cohen, A.H. (1987). The structure and function of the intersegmental coordinating system in the lamprey spinal cord. Journal of Comparative Physiology A 160, 181–193.CrossRefGoogle Scholar
  5. Cohen, A.H., B. Ermentrout, T. Kiemel, N. Kopell, K.A. Sigvardt, & T.L. Williams (1992). Modelling of intersegmental coordination in the lamrey central pattern generator for locomotion. Trends in Neurosciences 15, 434–438.CrossRefGoogle Scholar
  6. Cohen, A.H., P.J. Holmes, & R.H. Rand (1982). The nature of the coupling between segmental oscillators of the lamprey spinal generator for locomotion: A mathematical model. Journal of Mathematical Biology 13, 345–369.MathSciNetCrossRefzbMATHGoogle Scholar
  7. Cohen, A.H., & T. Kiemel (1993). Intersegmental coordination: Lessons from modeling systems of coupled non-linear oscillators. American Zoologist 33, 54–65.Google Scholar
  8. Cohen, A.H., R. Pitts, J.C. Presson, & L. Guan (1992). In larval lamprey the brainstem and spinal cord interact to produce a novel motor output. Society of Neuroscience Abstracts 18, 140–143.Google Scholar
  9. Cohen, A.H., & P. Wallén (1980). The neuronal correlate of locomotion in fish: “Fictive swimming” induced in an in vitro preparation of the lamprey spinal cord. Experimental Brain Research 41, 11–18.CrossRefGoogle Scholar
  10. Currie, S.N., & P.S.G. Stein (1990). Cutaneous stimulation evokes long-lasting excitation of spinal interneurons in the turtle. Journal of Neurophysiology 64, 1134–1148.Google Scholar
  11. Degtyarenko, A.M., E.S. Simon, T. Norden-Krichmar, & R.E. Burke (1998). Modulation of oligosynaptic cutaneous and muscle afferent reflex pathways during fictive locomotion and scratching in the cat. Journal of Neurophysiology 79, 447–463.Google Scholar
  12. Delcomyn, F. (1980). Neural basis of rhythmic behavior in animals. Science 210, 492–498.CrossRefGoogle Scholar
  13. Dubuc, R., J.-M. Cabelguen, & S. Rossignol (1985). Rhythmic antidromic discharges of single primary afferents recorded in cut dorsal root filaments during locomotion in the cat. Brain Research 359, 375–378.CrossRefGoogle Scholar
  14. Dubuc, R., J.-M. Cabelguen, & S. Rossignol (1988). Rhythmic fluctuations of dorsal root potentials and antidromic discharges of primary afferents during fictive locomotion in the cat. Journal of Neurophysiology 60, 2014–2037.Google Scholar
  15. Dykstra, S., T. Kiemel, & A.H. Cohen (1995). Analysis of transient behaviors in the lamprey locomotor central pattern generator during initiation and termination of mechanical entrainment. Neuroscience Abstracts 21, no. 277.5.Google Scholar
  16. El Manira, A., J. Tegnér, & S. Grillner (1996). Locomotor-related presynaptic modulation of primary afférents in the lamprey. European Journal of Neuroscience 9, 696–705.CrossRefGoogle Scholar
  17. Ermentrout, G.B., & N. Kopell (1994). Inhibition-produced patterning in chains of coupled nonlinear oscillators. SIAM Journal of Applied Mathematics 54, 478–507.MathSciNetCrossRefzbMATHGoogle Scholar
  18. Garcia-Rill, E., & R.D. Skinner (1988). Modulation of rhythmic function in the posterior midbrain. Neuroscience 27, 639–654.CrossRefGoogle Scholar
  19. Gossard, J.-P., J.-M. Cabelguen, & S. Rossignol (1991). An intracellular study of muscle primary afferents during fictive locomotion in the cat. Journal of Neurophysiology 65, 914–926.Google Scholar
  20. Grillner, S., J.T. Buchanan, P. Wallén, & L. Brodin (1988). Neural control of locomotion in lower vertebrates: From behavior to ionic mechanisms. In A.H. Cohen, S. Rossignol, & S. Grillner (eds.), Neural control of rhythmic movements in vertebrates (pp. 1–41). New York: Wiley.Google Scholar
  21. Jankowska, E., & A. Lundberg (1981). Intemeurones in the spinal cord. Trends in Neurosciences 4, 230–233.CrossRefGoogle Scholar
  22. Kasicki, S., S. Grillner, Y. Ohta, R. Dubuc, & L. Brodin (1989). Phasic modulation of reticulospinal neurones during fictive locomtion and other types of spinal motor activity in lamprey. Brain Research 484, 203–216.CrossRefGoogle Scholar
  23. Katz, P.S., & R. Harris-Warrick (1990). Neuromodulation of the crab pyloric central pattern generator by serotonerigc/cholinergic proprioceptive afferents. Journal of Neuroscience 10, 1495–1512.Google Scholar
  24. Kiemel, T. (1990). Three problems from the mathematics of neural oscillations. Doctoral Dissertation. Ithaca, NY: Cornell University.Google Scholar
  25. Kiemel, T., & A.H.Cohen (1998). Estimation of coupling strength in regenerated lamprey spinal cords based on a stochastic phase model. Journal of Computational Neuroscience 5, 267–284.CrossRefzbMATHGoogle Scholar
  26. Kopell, N., & G.B. Ermentrout (1988). Coupled oscillators and the design of central pattern generators. Mathematical Bioscience 90, 87–109.MathSciNetCrossRefzbMATHGoogle Scholar
  27. Libersat, F., A. Levy, & J.M. Camhi (1989). Multiple feedback loops in the flying cockroach: Excitation of the dorsal and inhibition of the ventral giant interneu-rons. Journal of Comparative Physiology 165, 651–668.CrossRefGoogle Scholar
  28. Lundberg, A. (1981). Half-centres revisited. Advances in Physiological Sciences 1, 155–167.Google Scholar
  29. Meilen, N., T. Kiemel, & A.H. Cohen (1994). Correlational analysis of fictive swimming in the lamprey reveals strong intersegmental coupling. Journal of Neurophysiology 73, 1020–1030.Google Scholar
  30. Rand, R.H., A.H. Cohen, & P.J. Holmes (1988). Systems of coupled oscillators as models of CPGs. In A.H. Cohen, S. Rossignol, & S. Grillner (eds.), Neural control of rhythmic movements in vertebrates (pp. 333–368). New York: Wiley.Google Scholar
  31. Ritzmann, R.E., A.J. Pollack, & M.L. Tobias (1982). Flight activity mediated by intracellular stimulation of dorsal giant intemeurons of the cockroach Periplaneta americana. Journal of Comparative Physiology 147, 313–322.CrossRefGoogle Scholar
  32. Rossignol, S., J.P. Lund, & T. Drew (1988). The role of sensory inputs in regulating patterns of rhythmical movements in higher vertebrates: A comparison between locomotion, respiration and mastication. In A.H. Cohen, S. Rossignol, & S. Grillner (eds.), Neural control of rhythmic movement in vertebrates (pp. 201–284). New York: Wiley.Google Scholar
  33. Rovainen, C.M. (1985). Effects of groups of propriospinal intemeurons on fictive swimming in the isolated spinal cord of the lamprey. Journal of Neurophysiology 54, 959–977.Google Scholar
  34. Somers, D., & N. Kopell (1993). Rapid synchronization through fast threshold modulation. Biological Cybernetics 68, 393–407.CrossRefGoogle Scholar
  35. Vinay, L., & S. Grillner (1993). The spino-reticulo-spinal loop can slow down the NMDA-activated spinal locomotor network in lamprey. NeuroReport 4, 609–612.CrossRefGoogle Scholar
  36. Wallén, P., & T.L. Williams (1984). Fictive locomotion in the lamprey spinal cord in vitro compared with swimming in the intact and spinal animal. Journal of Physiology (London) 347, 225–239.Google Scholar
  37. Williams, T.L., S. Grillner, V.V. Smoljaninov, P. Wallén, S. Kashin, & S. Rossignol (1989). Locomotion in lamprey and trout: The relative timing of activation and movement. Journal of Experimental Biology 143, 559–566.Google Scholar
  38. Williams, T.L., K.A. Sigvardt, N. Kopell, G.B. Ermentrout, & M.R Remler (1990). Forcing of coupled nonlinear oscillators: Studies of intersegmental coordination in the lamprey locomotor central pattern generator. Journal of Neurophysiology 64, 862–871.Google Scholar
  39. Wolf, H., & G. Laurent (1994). Rhythmic modulation of the responsiveness of locust sensory local interneurons by walking pattern generating networks. Journal of Neurophysiology 71, 110–118.Google Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2000

Authors and Affiliations

  • Avis H. Cohen
    • 1
  1. 1.University of MarylandCollege ParkUSA

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