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Modeling the metabolism of Penicillin-G formation

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Synthesis of β-Lactam Antibiotics

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Abstract

Micro-organisms have been used since many decades for the production of valuable chemicals for food, pharmaceutical and bulk industries. Examples are amino acids, vitamins, antibiotics or alcohols and organic acids (Table VII.1). Improvement of the production properties has been achieved using random classical mutation techniques. The development of recombinant-DNA techniques, the unraveling of complete genomes and genome wide information measurement (DNA chips) have recently opened the possibility of precise modifications in microbial metabolism. The goals of such “rational metabolic engineering” are “de novo” or improved production of desirable chemical compounds. Rational metabolic engineering opens the possibility to use micro-organisms for the production of a wider scope of bulk and fine chemicals. This is called the “cell factory concept”.

Table VII.1 Microbial production processes
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  1. Kluyver Laboratory for Biotechnology, Technical University Delft, Delft

    W. M. van Gulik, W. A. van Winden & J. J. Heijnen

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  1. Life Sciences R&D, DSM Research, Geleen, The Netherlands

    Alle Bruggink

  2. Department of Organic Chemistry, Nijmegen University, Nijmegen, The Netherlands

    Alle Bruggink

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van Gulik, W.M., van Winden, W.A., Heijnen, J.J. (2001). Modeling the metabolism of Penicillin-G formation. In: Bruggink, A. (eds) Synthesis of β-Lactam Antibiotics. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0850-1_7

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