Immunological aspects of Helicobacter pylori infection

  • H. J. Windle
  • A. M. Terrés
  • D. Kelleher
Part of the Immunology and Medicine Series book series (IMME, volume 31)

Abstract

Prior to the discovery of Helicobacter pylori it was considered unlikely that bacterial pathogens could colonise the stomach due to the arid environment created by acid secretion and other defensive factors. Microbial infection of the gastric mucosa is prevented in part by the production of mucus and several proteins with antibacterial actions, such as lysozyme and lactoferrin, as well as structurally by the tight junctions at the apical border of the epithelial cells. H. pylori, cultured for the first time from human gastric mucosa in 1983 (1), not only colonises human gastric epithelium but is also currently considered as the major aetiological agent in the pathogenesis of chronic gastritis and peptic ulcer disease (2, 3). Development of gastric cancer (4, 5) and lymphoma (6, 7) have also been related to H. pylori colonisation. It is now generally accepted that H. pylori infection is acquired in childhood from other infected individuals.

Keywords

Lymphoma Adenocarcinoma Bacillus Integrin Catalase 

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Copyright information

© Kluwer Academic Publishers 2001

Authors and Affiliations

  • H. J. Windle
  • A. M. Terrés
  • D. Kelleher

There are no affiliations available

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