Skip to main content
SpringerLink
Log in

Immunological aspects of Helicobacter pylori infection

  • Chapter
Immunological Aspects of Gastroenterology

Part of the book series: Immunology and Medicine Series ((IMME,volume 31))

  • 92 Accesses

Abstract

Prior to the discovery of Helicobacter pylori it was considered unlikely that bacterial pathogens could colonise the stomach due to the arid environment created by acid secretion and other defensive factors. Microbial infection of the gastric mucosa is prevented in part by the production of mucus and several proteins with antibacterial actions, such as lysozyme and lactoferrin, as well as structurally by the tight junctions at the apical border of the epithelial cells. H. pylori, cultured for the first time from human gastric mucosa in 1983 (1), not only colonises human gastric epithelium but is also currently considered as the major aetiological agent in the pathogenesis of chronic gastritis and peptic ulcer disease (2, 3). Development of gastric cancer (4, 5) and lymphoma (6, 7) have also been related to H. pylori colonisation. It is now generally accepted that H. pylori infection is acquired in childhood from other infected individuals.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Marshall B. Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet 1983;i:1273–1275.

    Google Scholar 

  2. Marshall B, Warren J. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet 1984:i:1311–1315.

    Google Scholar 

  3. Blaser M. Gastic Campylobacter-like organisms, gastritis, and peptic ulcer disease. Gastroenterology 1987;93:371–383.

    PubMed  CAS  Google Scholar 

  4. Parsonnet J, Friedman G, Vandersteen D, et al. Helicobacter pylori infection and the risk of gastric carcinoma. N. Engl. J. Med. 1991;325:1170–1171.

    Article  Google Scholar 

  5. Clarkson K, West K. Gastric cancer and Helicobacter pylori infection. J. Clin. Pathol. 1993;46:997–999.

    Article  PubMed  CAS  Google Scholar 

  6. Wotherspoon A, Ortiz-Hidalgo C, Falzon M, Issaacson P. Helicobacter pylori-associated gastritis and primary B-cell gastric lymphoma. Lancet 1991;338:1175–1176.

    Article  PubMed  CAS  Google Scholar 

  7. Bayerdorffer E, Neubauer A, Rudolph B, et al. Regression of primary gastric lymphoma of mucosa-associated lymphoid tissue type after cure ofHelicobacter pylori infection. MALT Lymphoma Study Group. Lancet 1995;345:1591–1594.

    Article  PubMed  CAS  Google Scholar 

  8. Marshall B, Barret L, Prakash C, McCallum R, Guerrant R. Urea protects Helicobacter (Campylobacter) pylori from the bactericidal effect of acid. Gastroenterology 1990;99:697–702.

    PubMed  CAS  Google Scholar 

  9. Wyle F, Tarnawski A, Schulman D, Dabros W. Evidence for gastric mucosal cell invasion by C. pylori: an ultrastructural study. J. Clin. Gastroenterol. 1990;12 Suppl. I:S92–98.

    Google Scholar 

  10. Lindholm C, Quiding-Jarbrink M, Lonroth H, Hamlet A, Svennerholm A. Local cytokine response in Helicobacter pylori-infected subjects. Infect. Immun. 1998;66:5964–5971.

    CAS  Google Scholar 

  11. Appelmelk B, Negrini R, Moran A, Kuipers E. Molecular mimicry between Helicobacter pylori and the host. Trends Microbiol. 1997;5:70–73.

    Article  PubMed  CAS  Google Scholar 

  12. Blanchard T, Czinn S, Nedrud J. Host response and vaccine development to Helicobacter pylori infection. Curr. Top. Microbiol. Immunol. 1999;241:181213.

    Google Scholar 

  13. Ilver D, Arngvist A, Ogren J, et al. Helicobacter pylori adhesin binding fucosylated histo-blood group antigens revealed by retagging. Science 1998;16:373–377.

    Article  Google Scholar 

  14. Smoot D, Resau J, Naab T, et al. Adherence of Helicobacter pylori to cultured human gastric epithelial cells. Infect. Immun. 1993;61:350–355.

    CAS  Google Scholar 

  15. Dytoc M, Gold B, Louie M. Comparison of H. pylori and attaching-effacing Escherichia coli adhesion to eukaryotic cells. Infect. Immun. 1992;61:448–456.

    Google Scholar 

  16. Terras A, Pajares J, Hopkins A, et al. Helicobacter pylori disrupts epithelial barrier function in a process inhibited by protein kinase C activators. Infect. Immun. 1998;66:2943–2950.

    Google Scholar 

  17. Goodwin C, Armstrong J, Marshal B. Campylobacter pyloridis, gastritis and peptic ulceration. J. Clin. Pathol. 1986;39:353–365.

    Article  PubMed  CAS  Google Scholar 

  18. Shimoyama T, Everett S, Dixon M, Axon A, Crabtree J. Chemokine mRNA expression in gastric mucosa is associated with Helicobacter pylori cagA positivity and severity of gastritis. J. Clin. Pathol. 1998;51:765–770.

    Article  PubMed  CAS  Google Scholar 

  19. Yashumoto K, Okamoto S, Mukaida N, Murakami S, Mai M, Matsushima K. Tumor necrosis factor alpha and interferon gamma synergistically induce interleukin 8 production in a human gastric cancer cell line through acting concurrently on AP-1 and NF-kB-like binding sites of the interleukin 8 gene. J. Biol. Chem. 1992;267:22506–22511.

    Google Scholar 

  20. Rieder G, Hatzi R, Walz A, Stolte M, Enders G. Differences in regulation of CXC-chemokines and IL-8 in Helicobacter pylori-associated gastritis. Immunology Letters 1999, 69 (Special issue, 10th International Congress of Mucosal Immunology Abstracts): 29.

    Google Scholar 

  21. Aihara M, Tsuchimoto D, Takizawa H, et al. Mechanisms involved in Helicobacter pylori-induced interleukin-8 production by a gastric cancer cell line MKN45. Infect. Immun. 1997;65:3218–3224.

    CAS  Google Scholar 

  22. Crabtree J, Peich P, Wyatt J, Stachl U, Lindley I. Gastric interleukin-8 and IL-8 autoantibodies in H. pylori infection. Scand. J. Immunol. 1993;37:65–70.

    CAS  Google Scholar 

  23. Harris P, Ernst P, Kawabata S, Kiyono H, Graham M, Smith P. Recombinant Helicobacter pylori urease activates primary mucosal macrophages. J. Infect. Dis. 1998;178:1516–1520.

    Article  PubMed  Google Scholar 

  24. Yes G, Brousard R, Crowe S, Reyes V. Increased expression of interleukin 16 by gastric epithelium during Helicobacter pylori infection. Immunology Letters 1999;69:29 (Special issue, 10th International Congress of Mucosal Immunology Abstracts).

    Google Scholar 

  25. Sobala G, Crabtree J, Dixon M, et al. Acute Helicobacter pylori infection: clinical features, local and systemic immune response, gastric mucosal histology, and gastric juice ascorbic acid concentrations. Gut 1991;32:14151418.

    Google Scholar 

  26. Tricottet V, Bruneval P, Vire O, et al. Campylobacter-like organisms and surface epithelium abnormalities in active, chronic gastritis in humans: an ultrastructural study. Ultrastruct. Pathol. 1986;10:113–122.

    CAS  Google Scholar 

  27. Alam K, Schubert T, Bologna S. Increased density of Helicobacter pylori on antral biopsy is associated with severity of acute and chronic inflammation and likelihood of duodenal ulceration. Am. J. Gastroenterol. 1992;87:424–428.

    PubMed  CAS  Google Scholar 

  28. Khulusi S, Mendall M, Patel P, Levy J, Badve S, Northfield T. Helicobacter pylori infection density and gastric inflammation in duodenal ulcer and non-ulcer subjects. Gut 1995;37:319–324.

    Article  PubMed  CAS  Google Scholar 

  29. Rachmilewitz D, Karmeli F, Eliakim R, et al. Enhanced gastric nitric oxide synthase activity in duodenal ulcer patients. Gut 1994;35:1394–1397.

    Article  PubMed  CAS  Google Scholar 

  30. Modlin R, Nutman T. Type 2 cytokines and negative immune regulation in human infections. Curr. Opin. Immunol. 1993;5:511–517.

    Google Scholar 

  31. Di-Tommaso A, Xiang Z, Bugnili M, et al. Helicobacter pylori-specific CD4+ T-cell clones from peripheral blood and gastric biopsies. Infect. Immunol. 1995;63:1102–1106.

    CAS  Google Scholar 

  32. Clerici M, Shearer G. A Th1-Th2 switch is a critical step in the etiology of HIV infection. Immunol. Today 1993;14:107–111.

    CAS  Google Scholar 

  33. Yamamura M, Wang X, Ohmen J, et al. Cytokine patterns of immunologically mediated tissue damage. J. Immunol. 1992;15:1470–1475.

    Google Scholar 

  34. Yamamura M, Uyemura K, Deans R, et al. Defining protective responses to pathogens: cytokine profiles in leprosy sesions. Science 1991;254:277–279.

    Article  PubMed  CAS  Google Scholar 

  35. DElios M, Manghetti M, Almerigogna F, et al. Different cytokine profile and antigen-specificity repertoire in Helicobacter pylori-specific T cell clones from the antrum of chronic gastritis patients with or without peptic ulcer. Eur. J. Immunol. 1997;27:1751–175.

    Article  CAS  Google Scholar 

  36. Fan X, Chua A, Shasi C, et al. Antigen-specific gastric lymphocyte responses to patients with gastric H. pylori infection and IFN-y production. Gastroenterology 1993;104 (Suppl): A698.

    Google Scholar 

  37. Fan X, Chua A, Shahi C, McDevitt J, Keeling P, Kelleher D. Gastric T lymphocyte responses to H. pylori in patients with H. pylori colonisation. Gut 1994;35:1379–1384.

    Article  Google Scholar 

  38. Bodger K, Wyatt J, Heatley R. Gastric mucosal secretion of interleukin-10: relations to histopathology, Helicobacter pylori status, and tumour necrosis factor-alpha secretion. Gut 1997;40:739–744.

    Article  PubMed  CAS  Google Scholar 

  39. Hatz R, Meimarakis G, Bayerdorffer E, Stolte M, Kirchner T, Enders G. Characterization of lymphocytic infiltrates in Helicobacter-pylori associated gastritis. Scand. J. Gastroenterol. 1996;31:222–228.

    CAS  Google Scholar 

  40. Seifarth C, Deusch K, Reich K, Classen M. Local cellular immune response in Helicobacter pylori associated type B gastritis--selective increase of CD4+ but not gamma delta T-cells in the immune response to H. pylori antigens. Z. Gastroenterol. 1996;34:215–224.

    CAS  Google Scholar 

  41. Genta R, Hamner H, Graham D. Gastric lymphoid follicles in Helicobacter pylori infection: frequency, distribution, and response to triple therapy. Hum. Pathol. 1993;24:577–583.

    CAS  Google Scholar 

  42. Sarsfield P, Jones D, Wotherspoon A, Harvard T, Wright D. A study of accessory cells in the acquired lymphoid tissue of Helicobacter gastritis. J. Pathol. 1996;180:18–25.

    Article  PubMed  CAS  Google Scholar 

  43. Terras A, Pajares J. An increased number of follicles containing activated CD69+ helper T cells and proliferating CD71+ B cells are found in H. pylori-infected gastric mucosa. Am. J. Gastroenterol. 1998;93:579–583.

    PubMed  Google Scholar 

  44. Hussell T, Isaacson P, Crabtree J, Spencer J. The response of cells from low grade B cell gastric lymphomas of mucosa-associated lymphoid tissue to Helicobacter pylori. Lancet 1993;342:571–574.

    Article  PubMed  CAS  Google Scholar 

  45. Eidt S, Stolte M, Fischer R. Helicobacter pylori gastritis and primary gastric non-Hodgkin¡¯s lymphoma. J. Clin. Pathol. 1994;47:436–439.

    Article  PubMed  CAS  Google Scholar 

  46. Nakamura S, Yao T, Aoyagi K, Lida M, Fujishima M, Tsuneyoshi M. Helicobacter pylori and primary gastric lymphoma. A histopathologic and immunohistochemical analysis of 237 patients. Cancer 1997;79:3–11.

    Article  PubMed  CAS  Google Scholar 

  47. Engstrand L, Scheynius A, Pahlson C. An increased number of gamma/delta T-cells and gastric epithelial cell expression of the groEL stress-protein homologue in Helicobacter pylori-associated chronic gastritis of the antrum. Am. J. Gastroenterol. 1991;86:976–980.

    PubMed  CAS  Google Scholar 

  48. Ibraghimov A, Kabok Z, Garcia G, Castriotta L, Torrey D, Papo J. Development of gastric aß+ CD4+ intraepihtelial lymphocytes induced by Helicobacter pylori infection. Immunology Letters 1999;69:29.

    Google Scholar 

  49. Scheynius A, Engstrand L. Gastric epithelial cells in Helicobacter pylori-associated gastritis express HLA-DR but not ICAM-1. Scand. J. Immunol. 1991;33:237–241.

    CAS  Google Scholar 

  50. Bergquist C, Mattsson-Rydberg A, Edebo A, Svennerholm A. Antigen presenting cells in the stomach and duodenum of Helicobacter pylori infected and healthy individuals. Immunology Letters 1999;69:50.

    Google Scholar 

  51. Fan X, Crowe S, Behar S, et al. The effect of class II major histocompatibility complex expression on adherence of Helicobacter pylori and induction of apoptosis in gastric epithelial cells: a mechanism for T helper cell type I-mediated damage. J. Exp. Med. 1998;18:1659–1669.

    Article  Google Scholar 

  52. Hatz R, Rieder G, Stolte M, et al. Pattern of adhesion molecule expression on vascular endothelium in Helicobacter pylori-associated antral gastritis. Gastroenterology 1997;112:1908–1919.

    Article  PubMed  CAS  Google Scholar 

  53. Darveau R, Cunningham M, Bailey T, et al. Ability of bacteria associated with chronic inflammatory diesease to stimulate E-selectin expression and promote neutrophil adhesion. Infect. Immun. 1995;63:1311–1317.

    CAS  Google Scholar 

  54. Campanero M, Pulido R, Ursa M, Rodriguez-Moya M, Landá;;duri Md, S¨¢nchez-Madrid F. ICAM-3 interacts with LFA-1 and regulates the LFA-1/ICAM-1 cell adhesion pathway. J. Cell. Biol. 1990;123:1007–1016.

    Google Scholar 

  55. Dougherty G, Hogg N. The role of monocyte lymphocyte function-associated antigen 1 (LFA-1) in accessory cell function. Eur. J. Immunol. 1987;17:943947.

    Google Scholar 

  56. Shaw S, Luce G, Quinones R, et al. Two antigen-independent adhesion pathways used by human cytotoxic T-cell clones. Nature 1986;323:262–2 64.

    Google Scholar 

  57. Malegapuru W, Martin E, Gale E, et a. ICAM-1 a ligand for LFA-1 dependent adhesion of B, T and myeloid cells. Nature 1988;331:86–88.

    Article  Google Scholar 

  58. Fan X, Long A, Fan S, Keeling P, Kelleher D. Adhesion molecule expression on gastric intraepithelial lymphocytes of patients with Helicobacter pylori infection. Eur. J. Gastroenterol. Hepatol. 1995;7:541–546.

    PubMed  CAS  Google Scholar 

  59. Higuchi K, Arakawa T, Uchida T, et al. In situ expression of cell adhesion molecules in chronic gastritis with Helicobacter pylori infection. J. Clin. Gastroenterol. 1997;25 (Suppl 1):S215–221.

    Article  PubMed  Google Scholar 

  60. Enders G, Brooks W, Von-Jan N, Lehn N, Bayerdorffer E, Hatz R. Expression of adhesion molecules on human granulocytes after stimulation with Helicobacter pylori membrane proteins: comparison with membrane proteins from other bacteria. Infect. Immun. 1995;63:2473–2477.

    CAS  Google Scholar 

  61. Mackay C, Terpe H, Stauder R, al e. Expression and modulation of CD44 variant isoforms in humans. J. Cell. Biol. 1994;124:71–82.

    Google Scholar 

  62. Mayer B, Jauch K, Gunthert U, et al. De-novo expression of CD44 and survival in gastric cancer. Lancet 1993;342:1019–1022.

    Article  PubMed  CAS  Google Scholar 

  63. Fan X, Long A, Goggins M, Fan X, Keeling P Kelleher D. Expression of CD44 and its variants on gastric epithelial cells of patients with Helicobacter pylori colonisation. Gut 1996;38:507–512.

    Article  PubMed  CAS  Google Scholar 

  64. Fixa B, Komarkova O, Krejsek J, Nozicka Z, Bures J. Specific cellular immune response in patients with Helicobacter pylori infection. Hepatogastroenterology 1990;37:606–607.

    PubMed  CAS  Google Scholar 

  65. Bak-Romaniszyn L, Malecka-Panas E, Zeman K, et al. Helicobacter pylori infection in the etiopathogenesis of duodenal ulcer in children. J. Physiol. Pharmacol. 1996;47:209–220.

    PubMed  CAS  Google Scholar 

  66. Kelly F, Amstrong P, Bamford K. Effect of Helicobacter pylori on ICAM-1 expression and cytokine production on monocytes and endothelial cells. Immunology Letters 1999;69:51–52.

    Google Scholar 

  67. Negrini R, Lisato L, Zanella I, et al. Helicobacter pylori infection induces antibodies cross-reacting with human gastric mucosa. Gastroenterology 1991;101:437–445.

    PubMed  CAS  Google Scholar 

  68. Rietschel E, Brade H, Holst O, et al. Bacterial endotoxin: Chemical constitution, biological recognition, host response, and immunological detoxification. Curr. Top. Microbiol. Immunol. 1996;216:39–81.

    Article  PubMed  CAS  Google Scholar 

  69. Aspinall G, Monteiro M, Pang H, Walsh E, Moran A. Lipopolysaccharide of the Helicobacter pylori type strain NCTC 11637 (ATCC 43504): structure of the O antigen chain and core oligosaccharide regions. Biochemistry 1996;35:24892497.

    Google Scholar 

  70. Appelmelk B, Simoons-Smith, Negrini R, et al. Potential role of molecular mimicry between Helicobacter pylori lipopolysaccharide and host Lewis blood group antigens in autoimmunity. Infect. Immun. 1996, 64: 2031–2040.

    CAS  Google Scholar 

  71. Wirth I-I, Yang M, Jr RP, Tham K, Blaser M. Helicobacter pylori Lewis expression is related to the host Lewis phenotype. Gastroenterology 1997;113:1091–1098.

    Article  PubMed  CAS  Google Scholar 

  72. Monteiro M, Chan K, Rasko D, et al. Simultaneous expression of type 1 and type 2 Lewis blood group antigens by Helicobacter pylori lipopolysaccharides. Molecular mimicry between H. pylori lipopolysaccharides and human gastric epithelial cell surface glycoforms. J. Biol. Chem. 1998;273:11533–11543.

    Article  PubMed  CAS  Google Scholar 

  73. Birkholz S, Knipp U, Nietzki C, Adamek R, Opferkuch W. Immunological activity of lipopolysaccharide of Helicobacter pylori on human peripheral mononuclear blood cells in comparison to lipopolysaccharides of other intestinal bacteria. FEMS Immunol. Med. Microbiol. 1993;6:317–324.

    CAS  Google Scholar 

  74. Moran A. The role of lipopoysaccharide in Helicobacter pylori pathogenesis. Aliment. Pharmacol. Ther. 1996;10 (Suppl 1):39–50.

    CAS  Google Scholar 

  75. Toh B, van-Driel I, Gleeson P. Autoimmune gastritis: tolerance and autoimmunity to the gastric H+/K+ ATPase (proton pump). Autoimmunity 1992;13:165–172.

    Article  PubMed  CAS  Google Scholar 

  76. Claeys D, Faller G, Appelmelk B, Negrini R, Kirchner T. The gastric H},K+ATPase is a major autoantigen in chronic Helicobacter pylori gastritis with body mucosa atrophy. Gastroenterology 1998;115:340–347.

    Article  PubMed  CAS  Google Scholar 

  77. Faller G, Winter M, Steininger H, et al. Decrease of antigastric autoantibodies in Helicobacter pylori gastritis after cure of infection. Pathol. Res. Pract. 1999;195:243–246.

    CAS  Google Scholar 

  78. Vorobjova T, Faller G, Maaroos H, Kirchner H, Villako K, Uibo R. Anticanalicular autoantibodies in an adult sample with high seroprevalence of Helicobacter pylori: a follow up study. Immunology Letters 1999;69:49.

    Google Scholar 

  79. Boren T, Falk P, Roth K, Larson G, Normark S. Attachment of Helicobacter pylori to human gastric epithelium mediated by blood group antigens. Science 1993;262:1892–1895.

    Article  PubMed  CAS  Google Scholar 

  80. Rathbone B, Wyatt J. Systemic and local antibody responses to gastric Campylobacter pyloridis in nonulcer dyspepsia. Gut 1986;27:642–647.

    Article  PubMed  CAS  Google Scholar 

  81. Crabtree J, Shallcross T, Wyatt J, et al. Mucosal humoral immune response to Helicobacter pylori in patients with duodenitis. Dig. Dis. Sci. 1991;36:12661273.

    Google Scholar 

  82. Shimoyama T, Crabtree J. Bacterial factros and immune pathogenesis in Helicobacter pylori infection. Gut 1998;43 (Suppl 1): S2–S5.

    PubMed  Google Scholar 

  83. Bontkes H, Veenendaal R, Pena A, et al. IgG subclass response to Helicobacter pylori in patients with chronic active gastritis and duodenal ulcer. Scand. J. Gastroenterol. 1992;27:129–33.

    CAS  Google Scholar 

  84. Andersen L, Gaarslev K. IgG subclass antibodies against Helicobacter pylori heat-stable antigens in normal persons and in dyspeptic patients. APMIS 1992;100:747–751.

    Article  PubMed  CAS  Google Scholar 

  85. Kreuning J, Lindeman J, Biemond I, Lamers C. Relation between IgG and IgA antibody titres against Helicobacter pylori in serum and severity of gastritis in asymptomatic subjects. J. Clin. Pathol. 1994;47:227–231.

    Article  PubMed  CAS  Google Scholar 

  86. Watanabe T, Goto H, Arisawa T, et al. Relationship between local immune response to Helicobacter pylori and the diversity of disease: investigation of H. pylori-specific IgA in gastric juice. J. Gastroenterol. Hepatol. 1997;12:660–665.

    Article  PubMed  CAS  Google Scholar 

  87. Futagami S, Takahashi H, Norose Y, Kobayashi M. Systemic and local immune responses against Helicobacter pylori urease in patients. Gut 1998;43:168–175.

    Article  PubMed  CAS  Google Scholar 

  88. Cutler A, Prasad V. Long-term follow-up of Helicobacter pylori serology after successful eradication. Am. J. Gastroenterol. 1996;91:85–88.

    PubMed  CAS  Google Scholar 

  89. Lerang F, Haug J, Mourn B, et al. Accuracy of IgG serology and other test in confirming Helicobacter pylori eradication. Scand. J. Gastroenterol. 1998;33:710–715.

    Article  CAS  Google Scholar 

  90. Sugiyama T, Awakawa T, Hayashi S, et al. The effect of the immune response to Helicobacter pylori in the development of intestinal metaplasia. Eur. J. Gastroenterol. Hepatol. 1994;6 (Suppl 1): S89–92.

    PubMed  Google Scholar 

  91. Xiang Z, Cemsini S, Bayeli P, et al. Analysis of expression of CagA and VacA virulence factors in 43 strains of Helicobacter pylori reveals that clinicals isolates can be divided into two major types and that CagA is not necessary for expression of the vacuolating cytotoxin. Infect. Immun. 1995;63:94–98.

    CAS  Google Scholar 

  92. Wyatt J, Rathbone B, Heatley R. Local immune response to gastric Campylobacter in non-ulcer dyspepsia. J. Clin. Pathol. 1986;39:863–870.

    Article  PubMed  CAS  Google Scholar 

  93. Kazi J, Sinniah R, Jaffrey N, et al. Cellular and humoral immune responses in Campylobacter pylori-associated chronic gastritis. J. Pathol. 1989;159:231–237.

    Article  PubMed  CAS  Google Scholar 

  94. Darwin P, Zheng MSQ, James S, Fantry G. Immune evasion by Helicobacter pylori: gastric spiral bacteria lack surface immunoglobulin deposition and reactivity with homologous antibodies. Helicobacter 1996;1:20–27.

    Article  PubMed  CAS  Google Scholar 

  95. Birkholz S, Schneider T, Knipp U, Stallmach A, Zeitz M. Decreased Helicobacter pylori-specific gastric secretory IgA antibodies in infected patients. Digestion 1998;59:638–645.

    Article  PubMed  CAS  Google Scholar 

  96. Windle H, Ní Eidhin D, Kelleher D. The thioredoxin system of Helicobacter pylori: a role for redox activity in pathogenesis? Immunology Letters 1999;69:49–50.

    Google Scholar 

  97. Schutze K, Hentsche E, Dragosict B, Hirschl A. Helicobacter pylori reinfection with identical organisms: transmission by the patients’ spouses. Gut 1995;36:831–833.

    Article  PubMed  CAS  Google Scholar 

  98. Walker R. New strategies for using mucosal vaccination to achieve more effective immunization. Vaccine 1994;12:387–400.

    Article  PubMed  CAS  Google Scholar 

  99. Czinn S, Nedrud J. Oral immunization against Helicobacter pylori. Infect. Immun. 1991;59:2359–2363.

    CAS  Google Scholar 

  100. Chen M, Lee A, Hazell S. Immunisation against gastric Helicobacter infection in a mouse/Helicobacter felis model. Lancet 1992;339:1120–1121.

    Article  PubMed  CAS  Google Scholar 

  101. Ferrero R, Thiberge J, Huerre M, Labigne A. Recombinant antigens prepared from the urease subunits of Helicobacter spp.: evidence of protection in a mouse model of gastric infection. Infect. Immun. 1994;62:4981–4989.

    CAS  Google Scholar 

  102. Ferrero R, Thiberge J, Kansau I, Wuscher N, Huerre M, Labigne A. The GroES homolog of Helicobacter pylori confers protective immunity against mucosal infection in mice. Proc. Natl. Acad. Sci. U S A 1995;92:6499–6503.

    Article  PubMed  CAS  Google Scholar 

  103. Marchetti M, Rossi M, Giannelli V, et al. Protection against Helicobacter pylori infection in mice by intragastric vaccination with H. pylori antigens is achieved using a non-toxin mutant of E. coli heat-labile enterotoxin (LT) as adjuvant. Vaccine 1998;16:33–37.

    CAS  Google Scholar 

  104. Myers G, Ermak T, Georgakopoulos K, et al. Oral immunization with recombinant Helicobacter pylori urease confers long-lasting immunity against Helicobacter felis infection. Vaccine 1999;17:1394–1403.

    Article  PubMed  CAS  Google Scholar 

  105. Kim S, Doh H, Jong M, Ha Y, Chung S, Park H. Oral immunization with Helicobacter pylori-loaded poly-(D,L-Lactide-co-glycolide) nanoparticles. Helicobacter 1999;4:33–39.

    Article  PubMed  CAS  Google Scholar 

  106. Kim S, Doh H, Ahn J, et al. Induction of mucosal and systemic immune response by oral immunization with H. pylori lysates encapsulated in poly(D,Llactide-co-glyucolide) microparticles. Vaccine 1999;17:238–243.

    Article  Google Scholar 

  107. Michetti P, Dorta G, Wiesel P, et al. Effect of whey-based culture supernatant of Lactobacillus acidophilus (johnsonii) Lal on Helicobacter pylori infection in humans. Digestion 1999;60:203–209.

    Article  PubMed  CAS  Google Scholar 

  108. Campbell M, Tran C, Johnson R, Butler R, Davidson G. Hyperimmune bovine colostrum: protection of mice against Helicobacter pylori infection. Immunology Letters 1999;69:65–72.

    Google Scholar 

  109. Gomez-Duarte O, Bumann D, Meyer T. The attenuated Salmonella vaccine approach for the control of Helicobacter pylori-related diseases. Vaccine 1999;17:1667–1673.

    Article  PubMed  CAS  Google Scholar 

  110. Weltzin R, Klenthous H, Guirakhoo F, Monath T, Lee C. Novel intranasal immunization techniques for antibody induction and protection of mice against gastric Helicobacter felis infection. Vaccine 1997;15:370–376.

    Article  PubMed  CAS  Google Scholar 

  111. Kleanthous H, Myers G, Georgakopoulos K, et al. Rectal and intranasal immunizations with recombinant urease induce distinct local and serum immune responses in mice and protect against Helicobacter pylori infection. Infect. Immun. 1998;66:2879–2886.

    CAS  Google Scholar 

  112. Guy B, Hessler C, Fourage S, et al. Systemic immunization with urease protects mice against Helicobacter pylori infection. Vaccine 1998;16:850–856.

    Article  PubMed  CAS  Google Scholar 

  113. Guy B, Hessler C, Fourage S, Rokbi B, Millet M. Comparison between targeted and untargeted systemic immunizations with adjuvanted urease to cure Helicobacter pylori infection in mice. Vaccine 1999;5:370–376.

    Google Scholar 

  114. Nedrud J, Blanchard T, Gottwein J,et al. Systemic vaccination inducing either Th 1 or Th2 immunity protects mice from challenge with H. pylori. Immunology Letters 1999;69:52.

    Google Scholar 

  115. Michetti P, Kreiss C, Kotloff K, et al. Oral immunization with urease and Escherichia coli heat-labile enterotoxin is safe and immunogenic in Helicobacter pylori-infected adults. Gastroenterology 1999;116:804–812.

    Article  PubMed  CAS  Google Scholar 

  116. Dubois A, Lee C, Fiala N, Kleanthous H, Mehlman P, Monath T. Immunization against natural Helicobacter pylori infection in nonhuman primates. Infect. Immun. 1998;66:4340–4346.

    CAS  Google Scholar 

  117. Lee C, Soike K, Hill J, et al. Immunization with recombinant Helicobacter pylori urease decreases colonization levels following experimental infection of rhesus monkeys. Vaccine 1999;17:1493–1505.

    Article  PubMed  CAS  Google Scholar 

  118. Michetti P, Corthesy-Theulaz I, Davin C, et al. Immunization of BALB/c mice against Helicobacter fees infection with Helicobacter pylori urease. Gastroenterology 1994;107:1002–1011.

    PubMed  CAS  Google Scholar 

  119. Lee C, Weltzin R, Thomas WD Jr., et al. Oral immunization with recombinant Helicobacter pylori urease induces secretory IgA antibodies and protects mice from challenge with Helicobacter felis. J. Infec. Dis. 1995;172:161–172.

    Article  CAS  Google Scholar 

  120. Radcliff F, Hazell S, Kolesnikow T, Doidge C, Lee A. Catalase, a novel antigen for Helicobacter pylori vaccination. Infect. Immun. 1997;65:4668–4674.

    CAS  Google Scholar 

  121. Marchetti M, Arico B, Burroni D, Figura N, Rappuoli R, Ghiara P. Development of a mouse model of Helicobacter pylori infection that mimics human disease. Science 1995;267:1655–1658.

    Article  PubMed  CAS  Google Scholar 

  122. Mohammadi M, Nedrud J, Redline R, Lycke N, Czinn S. Murine CD4 T-cell response to Helicobacter infection: Th-1 cells enhance gastritis and cells reduce bacterial load. Gastroenterology 1997;113:1848–1857.

    Article  PubMed  CAS  Google Scholar 

  123. Blandchard T, Czinn S, Redline R, Sigmund N, Harriman G, Nedrud J. Antibody-independent protective mucosal immunity to gastric Helicobacter infection in mice. Cell. Immunol. 1999;10:74–80.

    Google Scholar 

Download references

Authors
  1. H. J. Windle
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. M. Terrés
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D. Kelleher
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of Nottingham and Queen’s Medical Centre, Nottingham, UK

    Y. R. Mahida

Rights and permissions

Reprints and permissions

Copyright information

© 2001 Kluwer Academic Publishers

About this chapter

Cite this chapter

Windle, H.J., Terrés, A.M., Kelleher, D. (2001). Immunological aspects of Helicobacter pylori infection. In: Mahida, Y.R. (eds) Immunological Aspects of Gastroenterology. Immunology and Medicine Series, vol 31. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0790-0_7

Download citation

  • DOI: https://doi.org/10.1007/978-94-010-0790-0_7

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-3852-2

  • Online ISBN: 978-94-010-0790-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation