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Molecular immunology of mucosal T cells

  • L. J. Saubermann
  • R. S. Blumberg
Part of the Immunology and Medicine Series book series (IMME, volume 31)

Abstract

The intestinal mucosal immune system has developed in response to its function in protecting the individual from the outside environment. The intestinal tissue can be organized into subcompartments of phenotypically distinct populations of T lymphocytes. These compartments include the epithelium and its associated intraepithelial lymphocytes (IELs), the lamina propria and the lamina propria lymphocytes (LPLs) and the gut-associated lymphoid tissue (GALT) which represents organized tissues, such as Peyer’s patches and mesenteric lymph nodes. Each of these compartments is now increasingly being recognized to contain a variety of distinct subsets of T cells that may have unique functions within the intestinal microenvironment. All of these subsets of T cells can be identified by their expression of particular surface molecules, including cell activation vs. naive cell markers, localization or adhesion markers, signaling pathways, cytokine expression, chemotactic factors, and the T cell receptor (TCR) itself.

Keywords

Intraepithelial Lymphocyte Immunological Aspect Molecular Immunology Gamma Delta Alpha Beta 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic Publishers 2001

Authors and Affiliations

  • L. J. Saubermann
  • R. S. Blumberg

There are no affiliations available

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