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Immunological Aspects of Gastroenterology pp 55–74Cite as

Role of epithelial cells in mucosal immunobiology

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Part of the book series: Immunology and Medicine Series ((IMME,volume 31))

Abstract

The intestinal mucosa constitutes an immunological organ where oral tolerance and defense against harmful organisms develops. Antigens must cross the intestinal epithelium in a controlled manner, since bacteria or their products are a primary risk factor for the development of intestinal inflammation (1, 2). The epithelium lining of the intestine is composed of a monolayer of cells which include transporting enterocytes, goblet cells, enteroendocrine cells, M cells, and Paneth cells. These intestinal epithelial cells are joined together at their apical poles by tight junctions that open and close in response to signals from the epithelium itself, the lamina propria or upon events in the lumen.

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  1. K. Luedtke-heckenkamp
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  2. H. C. Reinecker
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Editors and Affiliations

  1. University of Nottingham and Queen’s Medical Centre, Nottingham, UK

    Y. R. Mahida

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Luedtke-heckenkamp, K., Reinecker, H.C. (2001). Role of epithelial cells in mucosal immunobiology. In: Mahida, Y.R. (eds) Immunological Aspects of Gastroenterology. Immunology and Medicine Series, vol 31. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0790-0_3

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  • DOI: https://doi.org/10.1007/978-94-010-0790-0_3

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