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Hematopoietic Stem Cell Chimerism and Tolerance Induction

  • Chapter
Therapeutic Immunosuppression

Part of the book series: Immunology and Medicine Series ((IMME,volume 29))

  • 116 Accesses

Abstract

The immune system of mammals evolved to discriminate between self- and nonself-antigens. This assures protection from foreign pathogens without eliciting autoimmunity. The process of self/nonself discrimination is primarily acquired via positive and negative selection of T cells during ontogeny in the thymus. Thymic tolerance to self-antigens, however, is not absolute and several peripheral mechanisms have also evolved to reinforce tolerance to self-antigens and promote immunity to foreign antigens.

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Authors and Affiliations

  1. Institute for Cellular Therapeutics, University of Louisville, Louisville, Kentucky, USA

    Haval Shirwan & Suzanne T. Ildstad

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  1. Haval Shirwan
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  2. Suzanne T. Ildstad
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  1. University of Pittsburgh, Pittsburgh, PA, USA

    Angus W. Thomson

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Shirwan, H., Ildstad, S.T. (2001). Hematopoietic Stem Cell Chimerism and Tolerance Induction. In: Thomson, A.W. (eds) Therapeutic Immunosuppression. Immunology and Medicine Series, vol 29. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0765-8_8

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  • DOI: https://doi.org/10.1007/978-94-010-0765-8_8

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