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Local Immunosuppression: The Lung

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Therapeutic Immunosuppression

Part of the book series: Immunology and Medicine Series ((IMME,volume 29))

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Abstract

Lung transplantation represents an unusual situation in solid organ transplantation in that the graft is accessible to the external environment. In this situation aerosolized pharmacologic agents have direct access to the donor graft, and the technology for delivering medication by the inhalational route is well developed for other pulmonary disorders. In 1988, a team of investigators at the University of Pittsburgh made the decision to pursue aerosolized immunosuppression for lung transplant recipients based upon the belief that other limited models of localized immunosuppression have been successful, and the current pharmacologic regimen was not adequate for managing lung transplant rejection.

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Author information

Authors and Affiliations

  1. Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

    Aldo T. Iacono & Erdogan Kunter

  2. Department of Pharmacy and Therapeutics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

    Gilbert J. Burckart

  3. Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

    Adriana Zeevi

  4. Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

    Bartley P. Griffith

Authors
  1. Aldo T. Iacono
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  2. Gilbert J. Burckart
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  3. Adriana Zeevi
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  4. Erdogan Kunter
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  5. Bartley P. Griffith
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Editor information

Editors and Affiliations

  1. University of Pittsburgh, Pittsburgh, PA, USA

    Angus W. Thomson

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© 2001 Springer Science+Business Media Dordrecht

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Iacono, A.T., Burckart, G.J., Zeevi, A., Kunter, E., Griffith, B.P. (2001). Local Immunosuppression: The Lung. In: Thomson, A.W. (eds) Therapeutic Immunosuppression. Immunology and Medicine Series, vol 29. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0765-8_13

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  • DOI: https://doi.org/10.1007/978-94-010-0765-8_13

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-3821-8

  • Online ISBN: 978-94-010-0765-8

  • eBook Packages: Springer Book Archive

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