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Genetic Factors and the Role of Calcium in Alzheimer’s Disease Pathogenesis

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Calcium: The Molecular Basis of Calcium Action in Biology and Medicine

Abstract

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by impaired memory, cognition and altered behavior. Aging increases the incidence of AD from ∼10% in people 65 years of age or older to ∼47% in persons > 85 years. Although many theories have been proposed regarding the etiology of AD, the exact mechanisms involved are unknown and no effective cure exists. Exploring the role of calcium (Ca2+) in AD has begun to offer some insight into this devastating disease. This review will provide a basic background into AD pathology and genetics, followed by a more in depth focus on the evidence linking altered Ca2+ regulation to both the early-onset AD gene products and actual affected tissues.

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Authors and Affiliations

  1. Medical Biotechnology Center, Department of Neurology and Division of Human Genetics University of Maryland, Baltimore, MD, USA

    Mervyn J. Monteiro & Stacy M. Stabler

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  1. Mervyn J. Monteiro
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  2. Stacy M. Stabler
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  1. Université Libre de Bruxelles, Belgium

    Roland Pochet

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Monteiro, M.J., Stabler, S.M. (2000). Genetic Factors and the Role of Calcium in Alzheimer’s Disease Pathogenesis. In: Pochet, R., Donato, R., Haiech, J., Heizmann, C., Gerke, V. (eds) Calcium: The Molecular Basis of Calcium Action in Biology and Medicine. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0688-0_35

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  • DOI: https://doi.org/10.1007/978-94-010-0688-0_35

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