S100 Proteins and Fatty Acid Transport Are Altered in Skin Diseases
Fatty acids (FAs) are essential components for every living cell. FAs are used e.g. as metabolic fuels, as precursors of membrane lipids, or as bioactive molecules that participate in cell signaling. Disorders of FA-levels result in many diseases, indicating the existence of mechanisms that regulate FA-levels and the many diverse FA-tasks. Such regulatory mechanisms include the trafficking of FAs. In fact, FAs are highly hydrophobic and unstable molecules. They form poorly soluble salts (soap) with Ca2+ and possess surfactant properties that can become harmful to the cell. Therefore, FAs must be transported, solubilized and protected by FA-carriers.
KeywordsArachidonic Acid S100 Protein Lamellar Body Fatty Acid Transport Psoriatic Lesion
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