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Calcium: The Molecular Basis of Calcium Action in Biology and Medicine pp 287–303Cite as

The Epidermal Growth Factor Receptor and the Calcium Signal

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Abstract

Among the multiple systems that become operative during the mitogenic activation of a cell there is an early signal mediated by calcium. Thus, the cytosolic concentration of this ubiquitous second messenger tarnsiently increases when a variety of mitogenic receptors that belong to the superfamily of receptors with tyrosine kinase activity are activated by their ligans (Rozengurt, 1986). Among these receptors is the epidermal growth factor receptor (EGFR/ErbB1), a 170 kDa plasma membrane glycoprotein that, alike other related members of the ErbB family, is involved in proliferation, differentation and even the control of apoptotic processes (Carpenter, 1987; Ullrich and Schlessinger, 1990; Alroy and Yarden, 1997). In this review we will analyze how the EGFR generates the calcium signal, the subsequent activation of diverse Ca2+-dependent systems, and the role that these systems play on the regulation and fate of the receptor.

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Authors and Affiliations

  1. Instituto de Investigaciones Biomédicas, Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, Madrid, Spain

    Antonio Villalobo, María José Ruano, Paloma I. Palomo-Jiménez & Hongbing Li

  2. División de Genética, Departamento de Fisiología, Genética y Microbiología, Universidad de Alicante, Alicante, Spain

    José Martín-Nieto

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  1. Antonio Villalobo
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  1. Université Libre de Bruxelles, Belgium

    Roland Pochet

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Villalobo, A., Ruano, M.J., Palomo-Jiménez, P.I., Li, H., Martín-Nieto, J. (2000). The Epidermal Growth Factor Receptor and the Calcium Signal. In: Pochet, R., Donato, R., Haiech, J., Heizmann, C., Gerke, V. (eds) Calcium: The Molecular Basis of Calcium Action in Biology and Medicine. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0688-0_18

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