Abstract
In this chapter I will discuss some general mechanisms involved in cardiac inotropy and their relationship to cellular Ca overload and mismanagement. It is not intended as a comprehensive review of either inotropic agents or cardiac pathophysiology. I will start by considering five different means of cardiac inotropy: 1) hypothermia, 2) β-adrenergic activation, 3) α- adrenergic activation, 4) CaMKII activation and 5) cardioactive steroids (digitalis glycosides). Then I will discuss the ways in which cellular Ca regulation can go awry, with particular emphasis on Ca overload and heart failure. Finally, I will address strategic sites for induction of cardiac inotropy. This discussion may help to bring some of the characteristics of specific cellular systems discussed in preceding chapters into a more integrative picture of cellular Ca regulation.
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© 2001 Springer Science+Business Media Dordrecht
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Bers, D.M. (2001). Cardiac Inotropy and Ca Mismanagement. In: Excitation-Contraction Coupling and Cardiac Contractile Force. Developments in Cardiovascular Medicine, vol 237. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0658-3_10
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DOI: https://doi.org/10.1007/978-94-010-0658-3_10
Publisher Name: Springer, Dordrecht
Print ISBN: 978-0-7923-7158-8
Online ISBN: 978-94-010-0658-3
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