Effect of Aminoguanidine on Induced-diabetic Rabbits and Diabetic Patients with ESRD

  • Clinton D. Brown
  • Zhong Zhao
  • Loraine Thomas
  • Eli A. Friedman


Perturbation in blood rheology are thought to contribute to the genesis of progressive micro- and macrovascular complications in diabetes mellitus [1]. Specifically, hyper-viscosity of whole blood and plasma, and reduced RBC deformability (RBC-df), have been linked to the pathogenesis and progression of overt nephropathy in diabetic persons [2],[3]. In a previous study [4] we reported a highly significant correlation between RBC-df impairment and the loss of renal function in diabetic subjects.


Macrovascular Complication Advanced Glycation Endproducts Blood Rheology Erythrocyte Deformability Diabetic Person 
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Copyright information

© Springer Science+Business Media Dordrecht 2002

Authors and Affiliations

  • Clinton D. Brown
    • 1
  • Zhong Zhao
  • Loraine Thomas
  • Eli A. Friedman
    • 2
  1. 1.Department of MedicineBrooklyn
  2. 2.Department of MedicineSUNY, Downstate Medical CenterBrooklyn

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