Abstract
The combinatorial concept, originally coming from pharmaceutical research, is nowadays involved in a wide range of fields of research including the organometallic catalysis. Several methods for the preparation of metal- containing catalyst libraries on solid support or in solution phase are now available. Different screening strategies, particularly efficient for fast qualitative and quantitative evaluations of a large number of catalysts, were recently described. The impact of these methods as well as the interest of the High Throughput Experiment (HTE) concept on accelerated catalyst design in the field of homogeneous organometallic catalysis are discussed here.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Ed.: Bunin, E.D., (1998) The Combinatorial Index, Academic Press, San Diego; Ed.: Gordon, E.M., Kerwin, J.F. (1998) Combinatorial Chemistry and Molecular Diversity in Drug Discovery, Wiley, New York; Ed.: Chaiken, I.M., Janda, K.D., (1996) Molecular Diversity and Combinatorial Chemistry, American Chemical Society, Washington; Ed.: Czarnik, A.W., Ellman, J.A., (1996) Special Issue on Combinatorial Chemistry, Acc. Chem. Res., 29, 11-170.
Jandeleit, B. Schaefer, D. J., Powers, T. S., Turner, H. W. Weinberg W. H. (1999) Angew. Chem. Int. Ed, 38, 2494–2532.
Merrifield, R.B., (1963) J. Amer. Chem. Soc., 85,2149–2154.
Sherrigton, D.C., Hodge, P. (1988) Synthesis and separations using functional polymers, Wiley.
Atherton, E., Sheppard, R.C., (1989) Solid Phase Peptide Synthesis: A Practical Approach, Oxford.
a) Furka, A., (1982) Notarized document file number 36237/1982, Budapest; b) Furka, A., Sebestyen, F., Asgedom, M., Dibo, G., (1991) Int. J. Pept. Protein Res., 37, 487-493; c) Lam, K.S., Salmon, S.E., Hersh, E.M., Hruby, V.J., Kazmierski W.M., Knapp, R.J., (1991) Nature, 354,82-84; d) Houghten, R.A, Pinilla, C., Blondelle S.E., Appel, J.R., Dooley, C.T., Cuervo, J.H., (1991) Nature, 354,84-86.
Murer, P., Lewandowski, K., Svec, F., Frechet, J-M.J., (1998) Chem. Commun., 2559–2560.
a) Taylor, S.J., Morken, J.P., (1998) Science, 280,267–270; b) Harris, R. F., Nation, A. J., Copeland, G. T. Miller, S. J. (2000) J. Amer. Chem. Soc.122,11270-11271.
Sigman, M. S., Jacobsen, E. N., (1998) J. Amer. Chem. Soc., 120,5315–5316.
Strecker, A., (1850) Ann. Chem. Pharm., 75, 27.
Francis, M. B., Jacobsen, E. N. (1999) Angew. Chem. Int. Ed.38,937–941.
a) Chen, S., Janda, K.D., (1997) J. Amer. Chem. Soc., 119,8724–8725; Liu, S., Akhtar, M., Gani, D., (2000) Tetrahedron Lett, 41, 4493-4497.
JandaJel is a registered trademark of Aldrich Chemical Co.
Reger, T. S., Janda, K. D. (2000), J. Amer. Chem. Soc., 122,6929–6934.
Cole, B. M., Shimizu, K. D., Krueger, C. A., Harrity, J. P. A., Snapper, M. L., Hoveyda, A. H, (1996) Angew. Chem. Int. Ed. Engl. 35,1668–1671.
Shimizu, K. D., Cole, B. M., Krueger, C. A., Kuntz, K. W., Snapper, M. L., Hoveyda, A. H., (1997) Angew. Chem. Int. Ed. Engl. 36, 1704.
Gao X Kagan H. B. 1998 Chirality 10120–124
Szewczyk, J. W., Zuckerman, R. L., Bergman, R. G., Ellman, J. A., (2001) Angew. Chem. Int. Ed.40, 216–219.
Burgess, K., Lim, H.-J., Porte, A. M., Sulikowski, G. A., (1996) Angew. Chem. Int. Ed. Engl. 35,220–222.
Lavastre, O., Morken, J., (1999) Angew. Chem. Int. Ed, 38, 3163–3165.
Cooper, A. C., McAlexander, L. H., Lee, D.-H., Torres, M. T., Crabtree, R. H. (1998) J. Amer. Chem. Soc., 120,9971–9972.
Stambuli, J. P., Stauffer, S. R., Shaughnessy, K. H., Hartwig, J. F. (2001), J. Amer. Chem. Soc., 123, 2677–2678.
Stryer, L., Haugland, R.P., (1967) Proc. Natl. Acad. Sci., 58, 719–726.
a) Löber, O., Kawatsura, M., Hartwig, J. F. (2001) J. Amer. Chem. Soc., 123,4366–4367; b) Stauffer, S. R., Beare, N. A., Stambuli, J. P., Hartwig, J. F. (2001) J. Amer. Chem. Soc., 123,4641-4642; Shaughnessy, K. H., Kim, P., Hartwig, J. F. (1999) J. Amer. Chem. Soc., 121,2123-2132.
Nelson, S.G., (1998) Tetrahedron Asymmetry, 9, 357.
Taylor, S. J., Duffey, M. O., Morken, J. P. (2000) J. Amer. Chem. Soc., 122,4528–4529; Taylor, S. J., Morken, J. P., (1999) J. Amer. Chem. Soc., 121,12202-12203.
Ding, K., Ishii, A., Mikami, K., (1999) Angew. Chem. Int. Ed, 38, 497–500.
a) Liu, G., Ellman, J. A., (1995) J. Org. Chem., 60, 7712–7713; b) Porter, J. R., Traverse, J. F., Hoveyda, A. H., Snapper, M. L., (2001) J. Amer. Chem. Soc.123, 984-985; c) Reetz, M. T., (2001) Angew. Chem. Int. Ed, 40, 284-310; d) Gilberston, S.R., Wang, X., (1996) Tetrahedron Lett., 37, 6475-6478.
a)Taylor, S.J., Morken, J., (1999) Science, 280, 267–270; b) Reetz, M. T., Becker, M. H., Kühling, K. M., Holzwarth, A., (1998) Angew. Chem. Int. Ed, 37, 2647-2650; c) Reetz, M. T., Becker, M. H., Liebl, M., Fürstner, A., (2000), Angew. Chem. Int. Ed, 39, 1236-1239.
Reetz, M.T., Kuhling, K.M., Deege, A., Hinrichs, H., Beider, D., (2000), Angew. Chem. Int. Ed, 39, 3891–3893.
Reetz, M. T., Becker, M. H., Klein, H.-W. Stöckigt, D. (1999) Angew. Chem. Int. Ed, 38, 1758–1761.
Connolly, A. R., Sutherland, J. D. (2000) Angew. Chem. Int. Ed, 39, n°23, 4268–4271.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2002 Springer Science+Business Media Dordrecht
About this chapter
Cite this chapter
Lavastre, O., Pinault, N., Mincheva, Z. (2002). Organometallic Combinatorial Chemistry. In: Derouane, E.G., Parmon, V., Lemos, F., Ribeiro, F.R. (eds) Principles and Methods for Accelerated Catalyst Design and Testing. NATO Science Series, vol 69. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0554-8_7
Download citation
DOI: https://doi.org/10.1007/978-94-010-0554-8_7
Publisher Name: Springer, Dordrecht
Print ISBN: 978-1-4020-0721-7
Online ISBN: 978-94-010-0554-8
eBook Packages: Springer Book Archive