Abstract
In planning for public health protection from the likely adverse effects of human exposure to chemicals, a primary concern generally relates to whether or not the substance in question possesses potentially hazardous and/or toxic properties. In practice, an evaluation of the toxicological effects typically consists of a compilation of toxicological profiles of the chemicals of concern (including the intrinsic toxicological properties of the chemicals — that may include their acute, subchronic, chronic, carcinogenic, and/or reproductive effects) and a determination of the relevant toxicity indices. This chapter discusses the major underlying concepts, principles, and procedures that are often employed in the evaluation of the hazard effects or toxicity of various chemical constituents found in consumer products and/or in the human environment.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Suggested Further Reading
ATSDR, 1997. Technical Support Document for ATSDR Interim Policy Guideline: Dioxin and Dioxin-like Compounds in Soil, Agency for Toxic Substances and Disease Registry (ATSDR), US Department of Health and Human Services, Atlanta, GA
Crosby, DG, 1998. Environmental Toxicology and Chemistry, Oxford University Press, New York, NY
Klaassen, CD, 2002. Xenobiotic transporters: another protective mechanism for chemicals, International journal of Toxicology, 21(1): 7–12
NRC (National Research Council), 2002. Scientific Frontiers in Developmental Toxicology and Risk Assessment, National Academy Press, Washington, DC
Ottoboni, MA, 1997. The Dose Makes the Poison (A Plain Language Guide to Toxicology), 2nd edition, Van Nostrand Reinhold, ITP, New York
van Leeuwen, FXR, 1997. Derivation of toxic equivalency factors (TEFs) for dioxin-like compounds in humans and wildlife, Organohalogen Componds, 34: 237–269
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2002 Springer Science+Business Media New York
About this chapter
Cite this chapter
Asante-Duah, K. (2002). Evaluation of Chemical Toxicity. In: Public Health Risk Assessment for Human Exposure to Chemicals. Environmental Pollution, vol 6. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0481-7_7
Download citation
DOI: https://doi.org/10.1007/978-94-010-0481-7_7
Publisher Name: Springer, Dordrecht
Print ISBN: 978-1-4020-0921-1
Online ISBN: 978-94-010-0481-7
eBook Packages: Springer Book Archive