High-Density Compound Arrays of Combinatorial Chemical Libraries by a New Pen-Directed and Computer-Navigated Plotter Device

  • Stefan R. K. Hoffmann
Part of the American Peptide Symposia book series (APSY, volume 7)

Abstract

The search for new drugs and synthetic vaccines by screening the vast diversity of chemical structures is one of the most challenging goals of modern synthetic chemistry and molecular biology. While nature uses the three-dimensional structures of linear sequences of amino acids in peptides and proteins in nearly all the life processes, chemistry makes in principle accessible the whole structural space of chemical compounds and artificial protein architectures. But the de novo design of artificial architectures with predefined structure-function relationship is still a challenging problem, due to the unknown theoretical concepts in which nature rules a linear sequence to fold and to interact with a molecular ligand. In contrast, combinatorial chemistry allows the search for new structures with predefined function by screening the diversity of synthetic libraries. While the synthesis and screening of chemical libraries is quite routine both as bead- [1] and array-type libraries [2] since their introduction a decade ago, the development of new devices for their preparation can greatly simplify and boost their application for the search towards new drug-like compounds.

References

  1. 1.(a)
    Furka, A., Sebestyen, F., Asgedom, M., Dibo, G. Int. J. Pept. Protein Res. 37, 487–493 (1991).PubMedCrossRefGoogle Scholar
  2. 1.(b)
    Houghten, R.A., Pinilla, C., Blondelle, S.E., Appel, J.R., Dooley, C.T., Cuervo, J.H. Nature 354, 84–86 (1991).PubMedCrossRefGoogle Scholar
  3. 1.(c)
    Lam, K.S., Salmon, S.E., Hersh, E.M., Hruby, V.J., Kazmierski, W.M., Knapp, R.J. Nature 354, 82–84 (1991).PubMedCrossRefGoogle Scholar
  4. 2.
    Frank, R. Tetrahedron 48, 9217–9232 (1992).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2001

Authors and Affiliations

  • Stefan R. K. Hoffmann
    • 1
  1. 1.Department of BiochemistryUniversity of ZurichZurichSwitzerland

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